PPP1R12A Antibody - C-terminal region (ARP61148_P050)

Catalog No: ARP61148_P050

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WB Suggested Anti-PPP1R12A Antibody
Titration: 1.0 ug/ml
Positive Control: Jurkat Whole CellThere is BioGPS gene expression data showing that PPP1R12A is expressed in Jurkat

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PPP1R12A
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 86%; Rabbit: 100%; Rat: 100%
• Peptide Sequence: Synthetic peptide located within the following region: QDSDENEQEQQSDTEEGSNKKETQTDSISRYETSSTSAGDRYDSLLGRSG
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-PPP1R12A (ARP61148_P050) antibody is Catalog # AAP61148 (Previous Catalog # AAPP47303)
• Sample Type Confirmation:

  There is BioGPS gene expression data showing that PPP1R12A is expressed in Jurkat

• Subunit: 12A

Target Info

• Gene Symbol: PPP1R12A
• Gene Full Name: Protein phosphatase 1, regulatory subunit 12A
• Alias Symbols: MBS, GUBS, M130, MYPT1
• NCBI Gene Id: 4659
• Protein Name: Protein phosphatase 1 regulatory subunit 12A
• Description of Target: Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase.
• Uniprot ID: O14974
• Protein Accession #: NP_002471
• Nucleotide Accession #: NM_002480
• Protein Size (# AA): 1030
• Molecular Weight: 113kDa
• Protein Interactions: TP53; UBC; NUAK1; RPA3; RPA2; RPA1; TRIM47; AARSD1; PUS1; P3H1; RPRD1B; XPO5; OSGEP; NSUN2; NUSAP1; TTLL12; NUDT5; ARPC2; ACTR3; CUL1; TPP2; PFDN5; PFDN1; NRD1; PAN2; LATS1; gag; FMNL1; PAXIP1; IDH3G; CDV3; RHOA; LRRK2; ATXN10; SIAH2; FBXO25; ARRB2; ELAVL