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Datasheets/Manuals | Printable datasheet for anti-KRT18 antibody - OAAB04386 |
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Predicted Species Reactivity | Human, Mouse |
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Product Format | Liquid.PBS with 0.09% (W/V) sodium azide |
Clonality | Polyclonal |
Isotype | Rabbit Ig |
Host | Rabbit |
Application | IF, FC, IHC-P, WB |
Additional Information | Function: Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. Cellular Location: Cytoplasm, perinuclear region. Nucleus, nucleolus Tissue Location: Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma. |
Reconstitution and Storage | Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles. |
Immunogen | This CYK18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 401-430 amino acids from the C-terminal region of human CYK18. |
Purification | This antibody is purified by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Predicted Homology Based on Immunogen Sequence | Human; Mouse |
Concentration | 1.85 mg/ml |
Intended Use | For research use only and not for use in diagnostic or therapeutic procedures. |
Application Info | IF: 1:10~50 FC: 1:10~50 IHC-P: 1:10~50 WB: 1:1,000 Optimal dilutions should be determined by the end user. |
Other Applications Image 1 Data | Flow cytometric analysis of WiDr cells using CYK18 Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. |
Reference | Zhang,Q., Clin. Cancer Res. 15 (10), 3557-3567 (2009) Kruse,R., Folia Histochem. Cytobiol. 47 (1), 127-130 (2009) Toivola,D.M., Hepatology 40 (2), 459-466 (2004) |
Gene Symbol | KRT18 |
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Alias Symbols | K18, CK-18, CYK18 |
NCBI Gene Id | 3875 |
Protein Name | Keratin, type I cytoskeletal 18 |
Description of Target | KRT18 is the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament family. They are expressed in single layer epithelial tissues of the body. Mutations in its gene have been linked to cryptogenic cirrhosis. |
Uniprot ID | P05783 |
Protein Accession # | NP_000215.1 |
Molecular Weight | 48 kDa |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "KRT18 Antibody - C-terminal region (OAAB04386)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse".
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How long will it take to receive "KRT18 Antibody - C-terminal region (OAAB04386)"?
This item is available "Domestic: within 1-2 week delivery | International: within 1-2 week delivery".
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What buffer format is "KRT18 Antibody - C-terminal region (OAAB04386)" provided in?
This item is provided in "Liquid.PBS with 0.09% (W/V) sodium azide".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "KRT18 Antibody - C-terminal region (OAAB04386)"?
This target may also be called "K18, CK-18, CYK18" in publications.
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What is the shipping cost for "KRT18 Antibody - C-terminal region (OAAB04386)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "KRT18 Antibody - C-terminal region (OAAB04386)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "KRT18 Antibody - C-terminal region (OAAB04386)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "48 kDa".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "KRT18 Antibody - C-terminal region (OAAB04386)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "KRT18"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "KRT18"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "KRT18"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "KRT18"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "KRT18"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "KRT18"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.