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Catalog No: ARP35457_P050
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ARP35457_P050
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Datasheets/ManualsPrintable datasheet for anti-KCNQ2 (ARP35457_P050) antibody
Product Info
Tested Species ReactivityHuman, Mouse
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationIHC, WB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the middle region of human KCNQ2
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 92%; Rat: 100%; Zebrafish: 93%
Peptide SequenceSynthetic peptide located within the following region: SIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAH
Concentration0.5 mg/ml
Blocking PeptideFor anti-KCNQ2 (ARP35457_P050) antibody is Catalog # AAP35457 (Previous Catalog # AAPP06694)
Sample Type Confirmation

There is BioGPS gene expression data showing that KCNQ2 is expressed in NCIH226

ReferenceEtxeberria,A., (2008) FASEB J. 22 (4), 1135-1143
Gene SymbolKCNQ2
Gene Full NamePotassium voltage-gated channel, KQT-like subfamily, member 2
Alias SymbolsEBN, BFNC, DEE7, EBN1, ENB1, HNSPC, KV7.2, KCNA11
NCBI Gene Id3785
Protein NamePotassium voltage-gated channel, KQT-like subfamily, member 2 EMBL AAP35692.1
Description of TargetThe M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by KCNQ2 and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in KCNQ2 are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1).The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.
Uniprot IDQ53Y30
Protein Accession #NP_742107
Nucleotide Accession #NM_172109
Protein Size (# AA)393
Molecular Weight44kDa
Protein InteractionsARIH2; KCNQ3; PRKCA; CALM3; CALM1; CALM2; KCNQ1;
  1. What is the species homology for "KCNQ2 Antibody - middle region (ARP35457_P050)"?

    The tested species reactivity for this item is "Human, Mouse". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish".

  2. How long will it take to receive "KCNQ2 Antibody - middle region (ARP35457_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "KCNQ2 Antibody - middle region (ARP35457_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "KCNQ2 Antibody - middle region (ARP35457_P050)"?

    This target may also be called "EBN, BFNC, DEE7, EBN1, ENB1, HNSPC, KV7.2, KCNA11" in publications.

  5. What is the shipping cost for "KCNQ2 Antibody - middle region (ARP35457_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "KCNQ2 Antibody - middle region (ARP35457_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "KCNQ2 Antibody - middle region (ARP35457_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "44kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "KCNQ2 Antibody - middle region (ARP35457_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "KCNQ2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "KCNQ2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "KCNQ2"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "KCNQ2"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "KCNQ2"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "KCNQ2"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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