Catalog No: ARP58065_P050
Price: $0.00
SKU
ARP58065_P050
Availability: Domestic: within 1-2 days delivery | International: 1-2 days
Bulk
Order
Aviva's
Satisfaction
Guarantee
Contact Us:
Shipping Info:
  • $55: Antibody & Protein in US
  • $55 + $25/Kit in US
  • Contact us for international orders.
Datasheets/ManualsPrintable datasheet for anti-RB1 (ARP58065_P050) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Pig, Rabbit
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the N terminal region of human RB1
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 93%; Human: 100%; Mouse: 80%; Pig: 93%; Rabbit: 93%; Rat: 79%
Peptide SequenceSynthetic peptide located within the following region: MPPKTPRKTAATAAAAAAEPPAPPPPPPPEEDPEQDSGPEDLPLVRLEFE
Concentration0.5 mg/ml
Blocking PeptideFor anti-RB1 (ARP58065_P050) antibody is Catalog # AAP58065 (Previous Catalog # AAPP32488)
Sample Type Confirmation

RB1 is strongly supported by BioGPS gene expression data to be expressed in Jurkat

Publications

Survivin antagonizes chemotherapy-induced cell death of colorectal cancer cells. Oncotarget. 9, 27835-27850 (2018). 29963241

Description
Gene SymbolRB1
Gene Full NameRetinoblastoma 1
Alias SymbolsRB, pRb, OSRC, pp110, p105-Rb, PPP1R130, p110-RB1
NCBI Gene Id5925
Protein NameRetinoblastoma-associated protein
Description of TargetThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
Uniprot IDP06400
Protein Accession #NP_000312
Nucleotide Accession #NM_000321
Protein Size (# AA)928
Molecular Weight106kDa
Protein InteractionsRAF1; E2F1; ABL1; HDAC1; KDM2A; SMARCA4; USP7; UBC; DYRK1A; NEFM; DYRK1B; MAGEA11; ENC1; PPP1CA; CDKN1C; CDKN1A; CDK6; CDK4; CDK2; CCNE1; CCNA2; CCND1; HDAC11; PAX5; HIF1A; E2F4; CEBPE; CCNA1; SUMO1; UBE2I; TFAP2A; CDK3; CDK1; CCNC; CCNB1; MRPS18B; SUMO2;
  1. What is the species homology for "RB1 Antibody - N-terminal region (ARP58065_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Pig, Rabbit".

  2. How long will it take to receive "RB1 Antibody - N-terminal region (ARP58065_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "RB1 Antibody - N-terminal region (ARP58065_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "RB1 Antibody - N-terminal region (ARP58065_P050)"?

    This target may also be called "RB, pRb, OSRC, pp110, p105-Rb, PPP1R130, p110-RB1" in publications.

  5. What is the shipping cost for "RB1 Antibody - N-terminal region (ARP58065_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "RB1 Antibody - N-terminal region (ARP58065_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "RB1 Antibody - N-terminal region (ARP58065_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "106kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "RB1 Antibody - N-terminal region (ARP58065_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "RB1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "RB1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "RB1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "RB1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "RB1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "RB1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

Write Your Own Review
You're reviewing:RB1 Antibody - N-terminal region (ARP58065_P050)
Your Rating
We found other products you might like!