Catalog No: ARP74173_P050
Price: $0.00
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ARP74173_P050
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Datasheets/ManualsPrintable datasheet for anti-RASA1 (ARP74173_P050) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the N-terminal region of Human RASA1
PurificationAffinity purified
Peptide SequenceSynthetic peptide located within the following region: GTVDEGDSLDGPEYEEEEVAIPLTAPPTNQWYHGKLDRTIAEERLRQAGK
Concentration0.5 mg/ml
Blocking PeptideFor anti-RASA1 (ARP74173_P050) antibody is Catalog # AAP74173
Gene SymbolRASA1
Alias SymbolsGAP, PKWS, RASA, p120, CMAVM, CM-AVM, CMAVM1, RASGAP, p120GAP, p120RASGAP
NCBI Gene Id5921
Description of TargetThe protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues.
Uniprot IDP20936
Protein Size (# AA)1047
Molecular Weight115kDa
Protein InteractionsARHGAP35; DOK1; KHDRBS1; DOK2; PLCG1; EGFR; ABL1; Mbp; ERBB4; ERBB3; ERBB2; APP; SOCS1; UBC; SPSB1; ZNF579; BBS10; TRMT2A; EIF1; SERPINA4; XRCC6; EZH2; NCK1; BTRC; NFKBIA; DOK4; AFAP1L2; DNAJA3; G3BP1; PAG1; AURKB; MAP4K4; SOCS3; BIRC5; ARHGAP1; ARHGAP5;
  1. What is the species homology for "RASA1 Antibody - N-terminal region (ARP74173_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "RASA1 Antibody - N-terminal region (ARP74173_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "RASA1 Antibody - N-terminal region (ARP74173_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "RASA1 Antibody - N-terminal region (ARP74173_P050)"?

    This target may also be called "GAP, PKWS, RASA, p120, CMAVM, CM-AVM, CMAVM1, RASGAP, p120GAP, p120RASGAP" in publications.

  5. What is the shipping cost for "RASA1 Antibody - N-terminal region (ARP74173_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "RASA1 Antibody - N-terminal region (ARP74173_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "RASA1 Antibody - N-terminal region (ARP74173_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "115kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "RASA1 Antibody - N-terminal region (ARP74173_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "RASA1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "RASA1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "RASA1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "RASA1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "RASA1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "RASA1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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