PTPN6 Antibody - middle region (ARP61398_P050)

Catalog No: ARP61398_P050

WB Suggested Anti-PTPN6 Antibody
Titration: 1.0 ug/ml
Positive Control: THP-1 Whole Cell

Rabbit Anti-PTPN6 Antibody
Catalog Number: ARP61398_P050
Formalin Fixed Paraffin Embedded Tissue: Human Lymph Node Tissue
Observed Staining: Cytoplasm
Primary Antibody Concentration: 1:100
Other Working Concentrations: N/A
Secondary Antibody: Donkey anti-Rabbit-Cy3
Secondary Antibody Concentration: 1:200
Magnification: 20X
Exposure Time: 0.5 - 2.0 sec

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 93%; Zebrafish: 93%
• Peptide Sequence: Synthetic peptide located within the following region: WEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDS
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-PTPN6 (ARP61398_P050) antibody is Catalog # AAP61398 (Previous Catalog # AAPP47516)

Target Info

• Gene Symbol: PTPN6
• Gene Full Name: Protein tyrosine phosphatase, non-receptor type 6
• Alias Symbols: HCP, HCPH, SHP1, SHP-1, HPTP1C, PTP-1C, SHP-1L, SH-PTP1
• NCBI Gene Id: 5777
• Protein Name: Tyrosine-protein phosphatase non-receptor type 6
• Description of Target: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling.
• Uniprot ID: P29350
• Protein Accession #: NP_002822
• Nucleotide Accession #: NM_002831
• Protein Size (# AA): 595
• Molecular Weight: 65kDa
• Protein Interactions: FHL3; UBC; Siglece; PANK4; SAMD4B; SMAD3; TXN; CD300LF; SIGLEC12; LILRB4; LILRB2; TREML1; KIR2DL3; SPATA2; C6orf25; KLRAP1; TMEM62; PILRB; SIGLEC10; FCGR2B; CUZD1; BTLA; SIGLEC11; SLAMF6; TLR10; GAB2; PAG1; PILRA; CLEC4A; KIR2DL5A; ACTN4; BLNK; STAT5B; IR