Catalog No: ARP31175_P050
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ARP31175_P050
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Datasheets/ManualsPrintable datasheet for anti-E2F4 (ARP31175_P050) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationIHC, WB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the C terminal region of human E2F4
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
Peptide SequenceSynthetic peptide located within the following region: SSELLEELMSSEVFAPLLRLSPPPGDHDYIYNLDESEGVCDLFDVPVLNL
Concentration0.5 mg/ml
Blocking PeptideFor anti-E2F4 (ARP31175_P050) antibody is Catalog # AAP31175 (Previous Catalog # AAPP01918)
ReferenceDuPree,E.L., et al., (2004) Cancer Res. 64 (13), 4390-4393
Gene SymbolE2F4
Gene Full NameE2F transcription factor 4, p107/p130-binding
Alias SymbolsE2F-4
NCBI Gene Id1874
Protein NameTranscription factor E2F4
Description of TargetThe protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins. It is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It also plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer.
Uniprot IDQ16254
Protein Accession #NP_001941
Nucleotide Accession #NM_001950
Protein Size (# AA)413
Molecular Weight44kDa
Protein InteractionsRBL2; TFDP1; RBL1; RB1; XPO1; PCM1; HDAC1; POLR1D; CHMP2A; AP3S2; TRIM28; LIN9; ARID3A; NCOR2; HDAC3; AR; CEBPA; LIN54; LIN37; UBC; ATAD2; SIN3A; ASH2L; HCFC1; TRRAP; KAT2A; ID2; E2F1; KMT2A; ID3; SMAD3; NOLC1; TFDP2; NDN; SMAD2; BRCA1; RYBP; RNF144A; FHL
  1. What is the species homology for "E2F4 Antibody - C-terminal region (ARP31175_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish".

  2. How long will it take to receive "E2F4 Antibody - C-terminal region (ARP31175_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "E2F4 Antibody - C-terminal region (ARP31175_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "E2F4 Antibody - C-terminal region (ARP31175_P050)"?

    This target may also be called "E2F-4" in publications.

  5. What is the shipping cost for "E2F4 Antibody - C-terminal region (ARP31175_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "E2F4 Antibody - C-terminal region (ARP31175_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "E2F4 Antibody - C-terminal region (ARP31175_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "44kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "E2F4 Antibody - C-terminal region (ARP31175_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "E2F4"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "E2F4"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "E2F4"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "E2F4"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "E2F4"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "E2F4"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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