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CCND1 antibody - middle region (AVARP03037_P050)

Description of Target:
CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Gene Symbol:
CCND1
Official Gene Full Name:
Cyclin D1
NCBI Gene Id:
595
Alias Symbols:
BCL1; D11S287E; PRAD1; U21B31
Tissue Tool:
Find tissues and cell lines supported to express CCND1.
Protein Accession #:
NP_444284
Nucleotide Accession#:
NM_053056
Swissprot Id:
P24385
Host:
Rabbit
Clonality:
Polyclonal
Protein Name:
G1/S-specific cyclin-D1
Protein Size (# AA):
295
Molecular Weight:
34kDa
Application:
WB
Partner Proteins:
AKAP8, AREG, ATF5, ATP5C1, CASP2, CDK11B, CDK14, CDK4, CDK6, CDKN1A, CDKN1B, CRABP2, DMTF1, DTNBP1, EFEMP2, EIF3K, MAF1, MAPK4, MCM10, NCOA2, NPDC1, PCNA, RARA, RBL2, RUNX1, VDR, AKAP8, ATP5C1, CASP2, CDK11B, CDK4, CDK6, CDKN1A, CDKN1B, CRABP2, DTNBP1, EFEMP2, EIF3K, MAF1, MCM10, NPDC1, PCNA, RAR
Immunogen:
The immunogen for anti-CCND1 antibody: synthetic peptide directed towards the middle region of human CCND1
Product Format:
Lyophilized powder
Purification:
Affinity Purified
Complete computational species homology data:
CCND1 antibody - middle region (AVARP03037_P050)
Predicted Homology Based on Immunogen Sequence:
Guinea pig: 100%; Human: 100%; Mouse: 100%; Rat: 100%; African clawed frog: 90%; Bovine: 90%; Chicken: 90%; Dog: 90%; Horse: 90%; Zebrafish: 81%
Species Reactivity:
Bovine, Dog, Guinea pig, Horse, Human, Mouse, Rat, Zebrafish
Datasheets / Downloads:
Printable datasheet for
anti-CCND1 antibody
- AVARP03037_P050
Peptide Sequence:
Synthetic peptide located within the following region: ACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI
Blocking Peptide:
For anti-CCND1 antibody is Catalog # AAP30439 (Previous Catalog # AAPP01023)
Target Reference:
Kibel,A.S., (2008) Prostate 68 (11), 1179-1186
Reconstitution and Storage:
Add 50 ul of distilled water. Final anti-CCND1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.

Computational species homology for CCND1 antibody (AVARP03037)

Product page for CCND1 antibody (AVARP03037)

The information below lists the predicted species and target name associated to the peptide antigen. Please note, all available target reference numbers to the antigen sequence are presented, including unreviewed and protein isoforms.
To search for antibodies by species, please visit Aviva’s Species Reactivity Page. To search Aviva’s catalog of antibodies by sequence, please visit Aviva’s Antibody Blast Tool.

Predicted Species & Target Target Reference Predicted Homology
African clawed frog CCND1 antibody; Xenopus laevis CCND1 antibody P50755 90%
African clawed frog ccnd1-a antibody; Xenopus laevis ccnd1-a antibody Q8AVQ4 90%
African clawed frog ccnd1-b antibody; Xenopus laevis ccnd1-b antibody Q7ZYJ6 90%
African elephant CCND1 antibody; Loxodonta africana CCND1 antibody G3UEU3 90%
African elephant LOC100669703 antibody; Loxodonta africana LOC100669703 antibody G3T0G2 90%
Atlantic salmon ccnd1 antibody; Salmo salar ccnd1 antibody C0H9B3 90%
Bovine CCND1 antibody; Bos taurus CCND1 antibody Q2KI22 90%
Chicken CCND1 antibody; Gallus gallus CCND1 antibody P55169 90%
Chicken CCND1 antibody; Gallus gallus CCND1 antibody F1NS84 90%
Chinese hamster Ccnd1 antibody; Cricetulus griseus Ccnd1 antibody A5A422 100%
Common turkey CCND1 antibody; Meleagris gallopavo CCND1 antibody G1NC37 90%
Dog CCND1 antibody; Canis familiaris CCND1 antibody Q64HP0 90%
Dog Cfa.16248 antibody; Canis familiaris Cfa.16248 antibody F1PPQ3 90%
Duckbill platypus CCND1 antibody; Ornithorhynchus anatinus CCND1 antibody F6YP86 90%
Giant panda CCND1 antibody; Ailuropoda melanoleuca CCND1 antibody G1L5C1 90%
Gray short-tailed opossum CCND1 antibody; Monodelphis domestica CCND1 antibody F6VW21 90%
Green anole CCND1 antibody; Anolis carolinensis CCND1 antibody G1KRZ8 90%
Guinea pig CCND1 antibody; Cavia porcellus CCND1 antibody H0V4A4 100%
Horse CCND1 antibody; Equus caballus CCND1 antibody F7E0N3 90%
Human CCND1 antibody; Homo sapiens CCND1 antibody P24385 100%
Human CCND1 antibody; Homo sapiens CCND1 antibody Q9H014 100%
Human CCND1 antibody; Homo sapiens CCND1 antibody Q6FI00 100%
Human CCND1 antibody; Homo sapiens CCND1 antibody B4DR06 100%
Little brown bat CCND1 antibody; Myotis lucifugus CCND1 antibody G1PHM5 100%
Mouse CCND1 antibody; Mus musculus CCND1 antibody P25322 100%
Mouse Ccnd1 antibody; Mus musculus Ccnd1 antibody Q790L7 100%
Mouse Ccnd1 antibody; Mus musculus Ccnd1 antibody Q3TC96 100%
Northern white-cheeked gibbon LOC100605736 antibody; Nomascus leucogenys LOC100605736 antibody G1RHJ0 100%
Rat CCND1 antibody; Rattus norvegicus CCND1 antibody P39948 100%
Rat Ccnd1 antibody; Rattus norvegicus Ccnd1 antibody Q1RP72 100%
Rat Ccnd1 antibody; Rattus norvegicus Ccnd1 antibody Q1JUA4 100%
Rhesus macaque CCND1 antibody; Macaca mulatta CCND1 antibody F7BZY1 100%
Small-eared galago CCND1 antibody; Otolemur garnettii CCND1 antibody H0X4X8 100%
Sumatran orangutan CCND1 antibody; Pongo abelii CCND1 antibody Q5R6J5 100%
Sumatran orangutan DKFZp469H0317 antibody; Pongo abelii DKFZp469H0317 antibody Q5REV4 100%
Western clawed frog ccnd1 antibody; Xenopus tropicalis ccnd1 antibody Q6GLD3 90%
Western clawed frog ccnd1 antibody; Xenopus tropicalis ccnd1 antibody F7B5E5 90%
Western clawed frog ccnd1 antibody; Xenopus tropicalis ccnd1 antibody F6TQ09 90%
Western clawed frog LOC100158484 antibody; Xenopus tropicalis LOC100158484 antibody B2GU16 81%
Zebra finch LOC100231612 antibody; Taeniopygia guttata LOC100231612 antibody H0Z4M3 90%
Zebrafish CCND1 antibody; Danio rerio CCND1 antibody Q90459 81%
Zebrafish ccnd1 antibody; Danio rerio ccnd1 antibody Q8QFP4 81%
Zebrafish ccnd1 antibody; Danio rerio ccnd1 antibody F8W347 81%
Zebrafish ccnd1 antibody; Danio rerio ccnd1 antibody A7YYE4 81%
Zebrafish ccnd2b antibody; Danio rerio ccnd2b antibody Q1L8M6 90%
Zebrafish ccnd2b antibody; Danio rerio ccnd2b antibody E7F773 90%

Product Protocols: CCND1 antibody tested with Human 721_B_Lymphoblast (AVARP03037_P050)

Aviva Systems Biology is the original manufacturer of this CCND1 antibody (AVARP03037_P050)

Click here to view the CCND1 antibody Western Blot Protocol

Product Datasheet Link: CCND1 antibody (AVARP03037_P050)

WB Suggested Anti-CCND1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: 721_B

Western Blot image:


Description of Target: CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Questions pertaining to this data can be directed to techsupport@avivasysbio.com

Aviva Systems Biology’s CCND1 antibody (AVARP03037_P050) has been tested using other cell lysates and tissues. To obtain more data about this antibody please email us at info@avivasysbio.com.

To order by phone call us at (888) 880-0001, fax us at (858) 552-6975 or send an email to info@avivasysbio.com. Aviva manufactures this antibody so we can offer the best price. Please contact us to request pricing information.

All of Aviva’s products are guaranteed for the applications and experimental sample types mentioned in the datasheet below. Are you curious if this product will work for you? Please contact us at techsupport@avivasysbio.com

 
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