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CCND1 antibody - middle region (AVARP03037_P050)

Description of Target:
CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Gene Symbol:
CCND1
Official Gene Full Name:
Cyclin D1
NCBI Gene Id:
595
Alias Symbols:
BCL1; D11S287E; PRAD1; U21B31
Tissue Tool:
Find tissues and cell lines supported to express CCND1.
Protein Accession #:
NP_444284
Nucleotide Accession#:
NM_053056
Swissprot Id:
P24385
Host:
Rabbit
Clonality:
Polyclonal
Protein Name:
G1/S-specific cyclin-D1
Protein Size (# AA):
295
Molecular Weight:
34kDa
Application:
WB
Partner Proteins:
AKAP8, AREG, ATF5, ATP5C1, CASP2, CDK11B, CDK14, CDK4, CDK6, CDKN1A, CDKN1B, CRABP2, DMTF1, DTNBP1, EFEMP2, EIF3K, MAF1, MAPK4, MCM10, NCOA2, NPDC1, PCNA, RARA, RBL2, RUNX1, VDR, AKAP8, ATP5C1, CASP2, CDK11B, CDK4, CDK6, CDKN1A, CDKN1B, CRABP2, DTNBP1, EFEMP2, EIF3K, MAF1, MCM10, NPDC1, PCNA, RAR
Immunogen:
The immunogen for anti-CCND1 antibody: synthetic peptide directed towards the middle region of human CCND1
Product Format:
Lyophilized powder
Purification:
Affinity Purified
Complete computational species homology data:
CCND1 antibody - middle region (AVARP03037_P050)
Predicted Homology Based on Immunogen Sequence:
Guinea pig: 100%; Human: 100%; Mouse: 100%; Rat: 100%; African clawed frog: 90%; Bovine: 90%; Chicken: 90%; Dog: 90%; Horse: 90%; Zebrafish: 81%
Species Reactivity:
Bovine, Dog, Guinea pig, Horse, Human, Mouse, Rat, Zebrafish
Datasheets / Downloads:
Printable datasheet for
anti-CCND1 antibody
- AVARP03037_P050
Peptide Sequence:
Synthetic peptide located within the following region: ACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI
Blocking Peptide:
For anti-CCND1 antibody is Catalog # AAP30439 (Previous Catalog # AAPP01023)
Key Reference:
Kibel,A.S., (2008) Prostate 68 (11), 1179-1186
Reconstitution and Storage:
Add 50 ul of distilled water. Final anti-CCND1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
 
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