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MAPK Signaling Pathway

The Mitogen-activated protein kinase (MAPK) pathway is a cellular pathway consisting of a large number of proteins that can be activated by a variety of extracellular stimuli. Activation of the MAPK pathway can result in a multitude of physiological effects, including apoptosis, cell proliferation, mitosis, and the transcription of several classes of genes. Although the specific intermediates of the MAPK pathway can vary dramatically depending on physiological state, cell type, and stimuli, the classical MAPK pathway operates in the following general sequence: external growth factors bind to a transmembrane protein receptor and this signal is propagated through RAS and Raf intermediates prior to phosphorylating three or more MAPKs in sequence. The MAPK pathway’s ubiquitous nature ensures that this pathway mediates the vast majority of cellular responses.
Aberrant MAPK activity, including constitutive activation or down-regulation, can lead to continuous and unregulated cellular proliferation or muted responses to external stimuli. As a result of its potential influence on such a wide variety of cellular processes, including signal transduction, amplification, and proliferation, the MAPK signaling pathway has been implicated in a broad range of diseases ranging from cancer to obesity. For instance, in many cancers, constitutively active MAPK signaling pathway components such as Ras and Raf induce cell proliferation in the absence of appropriate signals. Raf mutations have been identified in melanomas, thyroid, colorectal, and ovarian cancers[1]. Current research is focused on creating and evaluating the efficacy of many downstream MAPK modulators and inhibitors.

1. Wong. 2009. Recent developments in anti-cancer agents targeting the Ras/Raf/MEK/ERK Pathway. Recent Pat Anticancer Drug Discov. 4(1):28-35.

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MAPK signaling pathway I image by Aviva Systems Biology

MAPK signaling pathway II image by Aviva Systems Biology

 

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Showing 121 - 150 of 160
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    TGFBR2 antibody - N-terminal region (ARP44743_T100) in Human HepG2 using Western Blot

    TGFBR2 antibody - N-terminal region (ARP44743_T100)

    Protein Name:TGF-beta receptor type-2
    Catalog #:ARP44743_T100
    Type: pAb
    Reacts with: Cow, Goat, Human, Mouse, Pig, Rabbit, Rat, Sheep
    Application: WB
    Product Size: 100 ul
    Price (USD): $229.00
  • TRIAL 
    PPM1B antibody - N-terminal region (ARP57767_P050) in Human Jurkat using Western Blot

    PPM1B antibody - N-terminal region (ARP57767_P050)

    Protein Name:Protein phosphatase 1B
    Catalog #:ARP57767_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    NFATC4 antibody - N-terminal region (ARP38493_P050) in Human 721_B using Western Blot
    NFATC4 antibody - N-terminal region (ARP38493_P050) in Hum. Fetal Brain using Western Blot
    NFATC4 antibody - N-terminal region (ARP38493_P050) in Human Lung Tissue using Immunohistochemistry

    NFATC4 antibody - N-terminal region (ARP38493_P050)

    Protein Name:Nuclear factor of activated T-cells, cytoplasmic 4
    Catalog #:ARP38493_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB, IHC
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    MAPK12 antibody - N-terminal region (ARP56535_P050) in Human Jurkat using Western Blot

    MAPK12 antibody - N-terminal region (ARP56535_P050)

    Protein Name:Mitogen-activated protein kinase 12
    Catalog #:ARP56535_P050
    Type: pAb
    Reacts with: Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    CACNB4 antibody - middle region (ARP36763_P050) in Human MCF-7 using Western Blot
    CACNB4 antibody - middle region (ARP36763_P050) in Hum. Adult Placenta using Western Blot
    CACNB4 antibody - middle region (ARP36763_P050) in Hum. Fetal Muscle using Western Blot
    CACNB4 antibody - middle region (ARP36763_P050) in Hum. Adult Placenta using Western Blot

    CACNB4 antibody - middle region (ARP36763_P050)

    Protein Name:Voltage-dependent L-type calcium channel subunit beta-4
    Catalog #:ARP36763_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    MAP3K11 antibody - middle region (ARP56349_P050) in Human HepG2 using Western Blot

    MAP3K11 antibody - middle region (ARP56349_P050)

    Protein Name:Mitogen-activated protein kinase kinase kinase 11
    Catalog #:ARP56349_P050
    Type: pAb
    Reacts with: Cow, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    HSPA2 antibody - middle region (ARP55382_P050) in Human Jurkat using Western Blot
    HSPA2 antibody - middle region (ARP55382_P050) in Human Hela using Western Blot

    HSPA2 antibody - middle region (ARP55382_P050)

    Protein Name:Heat shock-related 70 kDa protein 2
    Catalog #:ARP55382_P050
    Type: pAb
    Reacts with: Cow, Dog, Goat, Guinea Pig, Human, Mouse, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    Rapgef2 antibody - middle region (ARP42770_P050) in Mouse Kidney using Western Blot
    Rapgef2 antibody - middle region (ARP42770_P050) in Human sperm and mouse liver using Western Blot

    Rapgef2 antibody - middle region (ARP42770_P050)

    Protein Name:Rap guanine nucleotide exchange factor 2 Ensembl ENSMUSP00000113778
    Catalog #:ARP42770_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    PLA2G4E antibody - C-terminal region (ARP53548_P050) in Human HepG2 using Western Blot

    PLA2G4E antibody - C-terminal region (ARP53548_P050)

    Protein Name:Cytosolic phospholipase A2 epsilon Ensembl ENSP00000413897
    Catalog #:ARP53548_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    MAP3K2 antibody - N-terminal region (ARP49223_P050) in Human MCF-7 using Western Blot

    MAP3K2 antibody - N-terminal region (ARP49223_P050)

    Protein Name:Mitogen-activated protein kinase kinase kinase 2
    Catalog #:ARP49223_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    DUSP5 antibody - middle region (ARP58225_P050) in Human COLO205 using Western Blot

    DUSP5 antibody - middle region (ARP58225_P050)

    Protein Name:Dual specificity protein phosphatase 5
    Catalog #:ARP58225_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    FGF14 antibody - middle region (ARP54710_P050) in Human Lung using Western Blot

    FGF14 antibody - middle region (ARP54710_P050)

    Protein Name:Fibroblast growth factor 14
    Catalog #:ARP54710_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    PTPRR antibody - C-terminal region (ARP45387_P050) in Human Jurkat using Western Blot

    PTPRR antibody - C-terminal region (ARP45387_P050)

    Protein Name:Putative uncharacterized protein DKFZp686K0257 EMBL CAE11876.1
    Catalog #:ARP45387_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    MEF2C antibody - middle region (P100852_P050) in Human COLO205 using Western Blot

    MEF2C antibody - middle region (P100852_P050)

    Protein Name:Myocyte-specific enhancer factor 2C
    Catalog #:P100852_P050
    Type: pAb
    Reacts with: Dog, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    CDC42 antibody - N-terminal region (AVARP01017_P050) in Human 721_B using Western Blot
    CDC42 antibody - N-terminal region (AVARP01017_P050) in human liver tissue using Immunohistochemistry

    CDC42 antibody - N-terminal region (AVARP01017_P050)

    Protein Name:Cell division control protein 42 homolog
    Catalog #:AVARP01017_P050
    Type: pAb
    Reacts with: Dog, Rabbit
    Application: WB, IHC
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    JUND antibody - C-terminal region (ARP38602_P050) in Human Placenta using Western Blot

    JUND antibody - C-terminal region (ARP38602_P050)

    Protein Name:Transcription factor jun-D
    Catalog #:ARP38602_P050
    Type: pAb
    Reacts with: Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    MOS antibody - middle region (ARP56631_P050) in Human NCI-H226 using Western Blot

    MOS antibody - middle region (ARP56631_P050)

    Protein Name:Proto-oncogene serine/threonine-protein kinase mos
    Catalog #:ARP56631_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Human, Mouse, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    NFATC2 antibody - N-terminal region (ARP37106_T100) in Mouse SP2/0 using Western Blot

    NFATC2 antibody - N-terminal region (ARP37106_T100)

    Protein Name:Nuclear factor of activated T-cells, cytoplasmic 2
    Catalog #:ARP37106_T100
    Type: pAb
    Reacts with: Cow, Dog, Horse, Human, Mouse, Pig, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $229.00
  • TRIAL 
    PRKCG antibody - middle region (ARP56426_P050) in Human 293T using Western Blot

    PRKCG antibody - middle region (ARP56426_P050)

    Protein Name:Protein kinase C gamma type
    Catalog #:ARP56426_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    CACNB3 antibody - N-terminal region (ARP34958_P050) in Human Jurkat using Western Blot

    CACNB3 antibody - N-terminal region (ARP34958_P050)

    Protein Name:Voltage-dependent L-type calcium channel subunit beta-3
    Catalog #:ARP34958_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    PPP3R1 antibody - N-terminal region (ARP56124_P050) in Human NCI-H226 using Western Blot

    PPP3R1 antibody - N-terminal region (ARP56124_P050)

    Protein Name:Calcineurin subunit B type 1
    Catalog #:ARP56124_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    MAP3K14 antibody - N-terminal region (ARP42161_P050) in THP-1 using Western Blot

    MAP3K14 antibody - N-terminal region (ARP42161_P050)

    Protein Name:Mitogen-activated protein kinase kinase kinase 14
    Catalog #:ARP42161_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    Fgf3 antibody - C-terminal region (ARP42224_P050) in Rat Liver using Western Blot

    Fgf3 antibody - C-terminal region (ARP42224_P050)

    Protein Name:FGF3 EMBL BAB84564.1
    Catalog #:ARP42224_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    MAP4K2 antibody - N-terminal region (ARP48632_P050) in Human Liver using Western Blot

    MAP4K2 antibody - N-terminal region (ARP48632_P050)

    Protein Name:Mitogen-activated protein kinase kinase kinase kinase 2
    Catalog #:ARP48632_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    MAPKAPK3 antibody - C-terminal region (ARP60321_P050) in Human HepG2 using Western Blot

    MAPKAPK3 antibody - C-terminal region (ARP60321_P050)

    Protein Name:MAP kinase-activated protein kinase 3
    Catalog #:ARP60321_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    MAP2K3 antibody - C-terminal region (ARP42065_P050) in Human 721_B using Western Blot
    MAP2K3 antibody - C-terminal region (ARP42065_P050) in Human Liver Tissue using Immunohistochemistry

    MAP2K3 antibody - C-terminal region (ARP42065_P050)

    Protein Name:Dual specificity mitogen-activated protein kinase kinase 3
    Catalog #:ARP42065_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB, IHC
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    PPM1A antibody - middle region (ARP57765_P050) in Human Heart using Western Blot

    PPM1A antibody - middle region (ARP57765_P050)

    Protein Name:Protein phosphatase 1A
    Catalog #:ARP57765_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    CACNG4 antibody - N-terminal region (ARP37694_T100) in Human Jurkat using Western Blot

    CACNG4 antibody - N-terminal region (ARP37694_T100)

    Protein Name:Voltage-dependent calcium channel gamma-4 subunit
    Catalog #:ARP37694_T100
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $229.00
  • TRIAL 
    STK3 antibody - C-terminal region (ARP48701_T100) in transfected Cos-7 using Western Blot
    STK3 antibody - C-terminal region (ARP48701_T100) in Human RPE-1 using Western Blot
    STK3 antibody - C-terminal region (ARP48701_T100) in Human Lung Tumor using Western Blot
    STK3 antibody - C-terminal region (ARP48701_T100) in Human kidney using Immunohistochemistry

    STK3 antibody - C-terminal region (ARP48701_T100)

    Protein Name:Serine/threonine-protein kinase 3
    Catalog #:ARP48701_T100
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: IHC, WB
    Product Size: 100 ul
    Price (USD): $229.00
  • TRIAL 
    RAC1 antibody - middle region (ARP57798_P050) in Human HepG2 using Western Blot
    RAC1 antibody - middle region (ARP57798_P050) in siRUVBL1 transfected human H1299 using Western Blot

    RAC1 antibody - middle region (ARP57798_P050)

    Protein Name:Ras-related C3 botulinum toxin substrate 3
    Catalog #:ARP57798_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00

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Showing 121 - 150 of 160