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MAPK Signaling Pathway

The Mitogen-activated protein kinase (MAPK) pathway is a cellular pathway consisting of a large number of proteins that can be activated by a variety of extracellular stimuli. Activation of the MAPK pathway can result in a multitude of physiological effects, including apoptosis, cell proliferation, mitosis, and the transcription of several classes of genes. Although the specific intermediates of the MAPK pathway can vary dramatically depending on physiological state, cell type, and stimuli, the classical MAPK pathway operates in the following general sequence: external growth factors bind to a transmembrane protein receptor and this signal is propagated through RAS and Raf intermediates prior to phosphorylating three or more MAPKs in sequence. The MAPK pathway’s ubiquitous nature ensures that this pathway mediates the vast majority of cellular responses.
Aberrant MAPK activity, including constitutive activation or down-regulation, can lead to continuous and unregulated cellular proliferation or muted responses to external stimuli. As a result of its potential influence on such a wide variety of cellular processes, including signal transduction, amplification, and proliferation, the MAPK signaling pathway has been implicated in a broad range of diseases ranging from cancer to obesity. For instance, in many cancers, constitutively active MAPK signaling pathway components such as Ras and Raf induce cell proliferation in the absence of appropriate signals. Raf mutations have been identified in melanomas, thyroid, colorectal, and ovarian cancers[1]. Current research is focused on creating and evaluating the efficacy of many downstream MAPK modulators and inhibitors.

1. Wong. 2009. Recent developments in anti-cancer agents targeting the Ras/Raf/MEK/ERK Pathway. Recent Pat Anticancer Drug Discov. 4(1):28-35.

 See Related Product List Below Pathway Image

MAPK signaling pathway I image by Aviva Systems Biology

MAPK signaling pathway II image by Aviva Systems Biology

 

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Showing 91 - 118 of 118
  Type Catalog # Product Product Images Price (USD)
  pAb ARP56626_P050 PRKX antibody - N-terminal region (ARP56626_P050)
Reacts with
Human, Rat
Application
WB
$289.00
  pAb ARP34952_P050 CACNA2D1 antibody - middle region (ARP34952_P050)
Reacts with
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Application
WB
$289.00
  pAb ARP42770_P050 Rapgef2 antibody - middle region (ARP42770_P050)
Reacts with
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Application
WB
$289.00
  pAb ARP56420_P050 PRKAR1B antibody - middle region (ARP56420_P050)
Reacts with
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
Application
WB
$289.00
  pAb ARP55412_P050 FGF13 antibody - middle region (ARP55412_P050)
Reacts with
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
Application
WB
$289.00
  pAb ARP53548_P050 PLA2G4E antibody - C-terminal region (ARP53548_P050)
Reacts with
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Application
WB
$289.00
  pAb ARP52051_P050 DUSP8 antibody - middle region (ARP52051_P050)
Reacts with
Cow, Dog, Guinea Pig, Human, Mouse, Rat
Application
WB
$289.00
  pAb ARP58225_P050 DUSP5 antibody - middle region (ARP58225_P050)
Reacts with
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
Application
WB
$289.00
  pAb ARP54710_P050 FGF14 antibody - middle region (ARP54710_P050)
Reacts with
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
Application
WB
$289.00
  pAb ARP41429_P050 PLA2G5 antibody - middle region (ARP41429_P050)
Reacts with
Cow, Dog, Guinea Pig, Horse, Human, Rat
Application
WB
$289.00
  pAb AVARP02063_P050 AKT2 antibody - N-terminal region (AVARP02063_P050)
Reacts with
Cow, Dog, Horse, Human, Mouse, Pig, Rat
Application
WB, IHC
$289.00
  pAb ARP37668_P050 CACNG1 antibody - N-terminal region (ARP37668_P050)
Reacts with
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Application
WB
$289.00
  pAb ARP56695_P050 PPP5C antibody - N-terminal region (ARP56695_P050)
Reacts with
Cow, Guinea Pig, Human, Mouse, Pig, Rat
Application
WB
$289.00
  pAb ARP35414_T100 CACNG6 antibody - N-terminal region (ARP35414_T100)
Reacts with
Cow, Dog, Guinea Pig, Human, Mouse, Rabbit, Rat
Application
WB
$229.00
  pAb ARP56440_P050 MAPK13 antibody - middle region (ARP56440_P050)
Reacts with
Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
Application
WB
$289.00
  pAb ARP42161_P050 MAP3K14 antibody - N-terminal region (ARP42161_P050)
Reacts with
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
Application
WB
$289.00
  pAb ARP56170_P050 RPS6KA2 antibody - middle region (ARP56170_P050)
Reacts with
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Application
WB
$289.00
  pAb ARP57731_P050 MAPK7 antibody - middle region (ARP57731_P050)
Reacts with
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Application
IHC, WB
$289.00
  pAb ARP32718_P050 NFKB2 antibody - N-terminal region (ARP32718_P050)
Reacts with
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Application
IHC, WB
$289.00
  pAb ARP53636_P050 HSPA1L antibody - C-terminal region (ARP53636_P050)
Reacts with
Cow, Dog, Goat, Horse, Human, Mouse, Pig, Rat
Application
WB
$289.00
  pAb ARP57798_P050 RAC1 antibody - middle region (ARP57798_P050)
Reacts with
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
Application
WB
$289.00
  pAb P100911_P050 JUN antibody - N-terminal region (P100911_P050)
Reacts with
Cow, Dog, Human, Mouse, Pig, Rabbit, Rat, Sheep
Application
CHIP, IHC, WB
$289.00
  pAb AVARP03041_P050 CDC25B antibody - N-terminal region (AVARP03041_P050)
Reacts with
Dog, Guinea Pig, Horse, Pig, Rabbit
Application
IHC, WB
$289.00
  pAb ARP52307_P050 CHP antibody - N-terminal region (ARP52307_P050)
Reacts with
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Application
IHC, WB
$289.00
  pAb ARP48701_T100 STK3 antibody - C-terminal region (ARP48701_T100)
Reacts with
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Application
IHC, WB
$229.00
  pAb ARP48346_P050 GADD45B antibody - middle region (ARP48346_P050)
Reacts with
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rat
Application
IHC, WB
$289.00
  pAb P100866_T100 SRF antibody - N-terminal region (P100866_T100)
Reacts with
Cow, Dog, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
Application
CHIP, WB
$229.00
  mAb OASA01398 FASLG Antibody (OASA01398)
Reacts with
Human
Application
ELISA, FC, IP
$660.00

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Showing 91 - 118 of 118