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MAPK Signaling Pathway

The Mitogen-activated protein kinase (MAPK) pathway is a cellular pathway consisting of a large number of proteins that can be activated by a variety of extracellular stimuli. Activation of the MAPK pathway can result in a multitude of physiological effects, including apoptosis, cell proliferation, mitosis, and the transcription of several classes of genes. Although the specific intermediates of the MAPK pathway can vary dramatically depending on physiological state, cell type, and stimuli, the classical MAPK pathway operates in the following general sequence: external growth factors bind to a transmembrane protein receptor and this signal is propagated through RAS and Raf intermediates prior to phosphorylating three or more MAPKs in sequence. The MAPK pathway’s ubiquitous nature ensures that this pathway mediates the vast majority of cellular responses.
Aberrant MAPK activity, including constitutive activation or down-regulation, can lead to continuous and unregulated cellular proliferation or muted responses to external stimuli. As a result of its potential influence on such a wide variety of cellular processes, including signal transduction, amplification, and proliferation, the MAPK signaling pathway has been implicated in a broad range of diseases ranging from cancer to obesity. For instance, in many cancers, constitutively active MAPK signaling pathway components such as Ras and Raf induce cell proliferation in the absence of appropriate signals. Raf mutations have been identified in melanomas, thyroid, colorectal, and ovarian cancers[1]. Current research is focused on creating and evaluating the efficacy of many downstream MAPK modulators and inhibitors.

1. Wong. 2009. Recent developments in anti-cancer agents targeting the Ras/Raf/MEK/ERK Pathway. Recent Pat Anticancer Drug Discov. 4(1):28-35.

 See Related Product List Below Pathway Image

MAPK signaling pathway I image by Aviva Systems Biology

MAPK signaling pathway II image by Aviva Systems Biology

 

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Showing 121 - 129 of 129
  Type Catalog # Product Product Images Price (USD)
  pAb OASA08684 Map2k5 Antibody (OASA08684)
Reacts with
Rat
Application
WB
$450.00
  pAb OASA08876 TRAF6 Antibody (OASA08876)
Reacts with
Human
Application
WB
$310.00
  Protein OPSA11010 HUMAN FGF 8 Recombinant Protein (25ug)
Reacts with
Human
Application
$440.00
  pAb P100639_T100 FOS antibody - C-terminal region (P100639_T100)
Reacts with
Bovine, Dog, Human, Mouse, Pig, Rat, Sheep
Application
WB
$229.00
  pAb P100787_P050 RELB antibody - middle region (P100787_P050)
Reacts with
Bovine, Dog, Horse, Human, Mouse, Rabbit
Application
WB
$289.00
  pAb P100852_P050 MEF2C antibody - middle region (P100852_P050)
Reacts with
Dog, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
Application
WB
$289.00
  pAb P100866_T100 SRF antibody - N-terminal region (P100866_T100)
Reacts with
Bovine, Dog, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
Application
CHIP, WB
$229.00
  pAb P100911_P050 JUN antibody - N-terminal region (P100911_P050)
Reacts with
Bovine, Dog, Human, Mouse, Pig, Rabbit, Rat, Sheep
Application
CHIP, WB
$289.00
  pAb P100985_P050 ELK4 Antibody - C-terminal region (P100985_P050)
Reacts with
Human
Application
WB
$289.00

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Showing 121 - 129 of 129