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Now Offering Over 85,203 Antibodies & 34,301 Antigens!

MAPK Signaling Pathway

The Mitogen-activated protein kinase (MAPK) pathway is a cellular pathway consisting of a large number of proteins that can be activated by a variety of extracellular stimuli. Activation of the MAPK pathway can result in a multitude of physiological effects, including apoptosis, cell proliferation, mitosis, and the transcription of several classes of genes. Although the specific intermediates of the MAPK pathway can vary dramatically depending on physiological state, cell type, and stimuli, the classical MAPK pathway operates in the following general sequence: external growth factors bind to a transmembrane protein receptor and this signal is propagated through RAS and Raf intermediates prior to phosphorylating three or more MAPKs in sequence. The MAPK pathway’s ubiquitous nature ensures that this pathway mediates the vast majority of cellular responses.
Aberrant MAPK activity, including constitutive activation or down-regulation, can lead to continuous and unregulated cellular proliferation or muted responses to external stimuli. As a result of its potential influence on such a wide variety of cellular processes, including signal transduction, amplification, and proliferation, the MAPK signaling pathway has been implicated in a broad range of diseases ranging from cancer to obesity. For instance, in many cancers, constitutively active MAPK signaling pathway components such as Ras and Raf induce cell proliferation in the absence of appropriate signals. Raf mutations have been identified in melanomas, thyroid, colorectal, and ovarian cancers[1]. Current research is focused on creating and evaluating the efficacy of many downstream MAPK modulators and inhibitors.

1. Wong. 2009. Recent developments in anti-cancer agents targeting the Ras/Raf/MEK/ERK Pathway. Recent Pat Anticancer Drug Discov. 4(1):28-35.

 See Related Product List Below Pathway Image

MAPK signaling pathway I image by Aviva Systems Biology

MAPK signaling pathway II image by Aviva Systems Biology

 

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Showing 121 - 127 of 127
  Type Catalog # Product Product Images Price (USD)
  pAb ARP32718_P050 NFKB2 antibody - N-terminal region (ARP32718_P050)
Reacts with
Bovine, Human, Rat, Dog, Pig, Horse, Rabbit, Guinea pig, Mouse
Application
IHC, WB
$289.00
  pAb ARP53636_P050 HSPA1L antibody - C-terminal region (ARP53636_P050)
Reacts with
Human, Mouse, Pig, Horse, Goat, Dog, Bovine, Rat
Application
WB
$289.00
  pAb ARP57798_P050 RAC1 antibody - middle region (ARP57798_P050)
Reacts with
Mouse, Zebrafish, Human, Bovine, Sheep, Dog, Horse, Rabbit, Rat, Guinea pig
Application
WB
$289.00
  pAb P100911_P050 JUN antibody - N-terminal region (P100911_P050)
Reacts with
Bovine, Dog, Human, Mouse, Pig, Rabbit, Rat, Sheep
Application
CHIP, IHC, WB
$289.00
  pAb AVARP03041_P050 CDC25B antibody - N-terminal region (AVARP03041_P050)
Reacts with
Dog, Guinea pig, Horse, Pig, Rabbit
Application
IHC, WB
$289.00
  pAb ARP52307_P050 CHP antibody - N-terminal region (ARP52307_P050)
Reacts with
Mouse, Human, Dog, Pig, Horse, Rabbit, Rat, Guinea pig, Bovine, Zebrafish
Application
IHC, WB
$289.00
  pAb ARP48701_T100 STK3 antibody - C-terminal region (ARP48701_T100)
Reacts with
Bovine, Rat, Human, Dog, Horse, Rabbit, Guinea pig, Mouse, Zebrafish
Application
IHC, WB
$229.00

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Showing 121 - 127 of 127