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MAPK Signaling Pathway

The Mitogen-activated protein kinase (MAPK) pathway is a cellular pathway consisting of a large number of proteins that can be activated by a variety of extracellular stimuli. Activation of the MAPK pathway can result in a multitude of physiological effects, including apoptosis, cell proliferation, mitosis, and the transcription of several classes of genes. Although the specific intermediates of the MAPK pathway can vary dramatically depending on physiological state, cell type, and stimuli, the classical MAPK pathway operates in the following general sequence: external growth factors bind to a transmembrane protein receptor and this signal is propagated through RAS and Raf intermediates prior to phosphorylating three or more MAPKs in sequence. The MAPK pathway’s ubiquitous nature ensures that this pathway mediates the vast majority of cellular responses.
Aberrant MAPK activity, including constitutive activation or down-regulation, can lead to continuous and unregulated cellular proliferation or muted responses to external stimuli. As a result of its potential influence on such a wide variety of cellular processes, including signal transduction, amplification, and proliferation, the MAPK signaling pathway has been implicated in a broad range of diseases ranging from cancer to obesity. For instance, in many cancers, constitutively active MAPK signaling pathway components such as Ras and Raf induce cell proliferation in the absence of appropriate signals. Raf mutations have been identified in melanomas, thyroid, colorectal, and ovarian cancers[1]. Current research is focused on creating and evaluating the efficacy of many downstream MAPK modulators and inhibitors.

1. Wong. 2009. Recent developments in anti-cancer agents targeting the Ras/Raf/MEK/ERK Pathway. Recent Pat Anticancer Drug Discov. 4(1):28-35.

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MAPK signaling pathway I image by Aviva Systems Biology

MAPK signaling pathway II image by Aviva Systems Biology

 

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    SOS1 Antibody (OASA04400)

    SOS1 Antibody (OASA04400)

    Protein Name:Son of sevenless homolog 1
    Catalog #:OASA04400
    Type: mAb
    Reacts with: Human
    Application: ELISA, IF, WB
    Product Size: 0.1mg
    Price (USD): $270.00
  • TRIAL 
    SRF antibody - N-terminal region (P100866_T100) in Human Jurkat using Western Blot
    SRF antibody - N-terminal region (P100866_T100) in HCT116 using Chromatin Immunoprecitation

    SRF antibody - N-terminal region (P100866_T100)

    Protein Name:Serum response factor
    Catalog #:P100866_T100
    Type: pAb
    Reacts with: Cow, Dog, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
    Application: CHIP, WB
    Product Size: 100 ul
    Price (USD): $229.00
  • TRIAL 
    STK3 antibody - C-terminal region (ARP48701_T100) in transfected Cos-7 using Western Blot
    STK3 antibody - C-terminal region (ARP48701_T100) in Human RPE-1 using Western Blot
    STK3 antibody - C-terminal region (ARP48701_T100) in Human Lung Tumor using Western Blot
    STK3 antibody - C-terminal region (ARP48701_T100) in Human kidney using Immunohistochemistry

    STK3 antibody - C-terminal region (ARP48701_T100)

    Protein Name:Serine/threonine-protein kinase 3
    Catalog #:ARP48701_T100
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: IHC, WB
    Product Size: 100 ul
    Price (USD): $229.00
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