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MAPK Signaling Pathway

The Mitogen-activated protein kinase (MAPK) pathway is a cellular pathway consisting of a large number of proteins that can be activated by a variety of extracellular stimuli. Activation of the MAPK pathway can result in a multitude of physiological effects, including apoptosis, cell proliferation, mitosis, and the transcription of several classes of genes. Although the specific intermediates of the MAPK pathway can vary dramatically depending on physiological state, cell type, and stimuli, the classical MAPK pathway operates in the following general sequence: external growth factors bind to a transmembrane protein receptor and this signal is propagated through RAS and Raf intermediates prior to phosphorylating three or more MAPKs in sequence. The MAPK pathway’s ubiquitous nature ensures that this pathway mediates the vast majority of cellular responses.
Aberrant MAPK activity, including constitutive activation or down-regulation, can lead to continuous and unregulated cellular proliferation or muted responses to external stimuli. As a result of its potential influence on such a wide variety of cellular processes, including signal transduction, amplification, and proliferation, the MAPK signaling pathway has been implicated in a broad range of diseases ranging from cancer to obesity. For instance, in many cancers, constitutively active MAPK signaling pathway components such as Ras and Raf induce cell proliferation in the absence of appropriate signals. Raf mutations have been identified in melanomas, thyroid, colorectal, and ovarian cancers[1]. Current research is focused on creating and evaluating the efficacy of many downstream MAPK modulators and inhibitors.

1. Wong. 2009. Recent developments in anti-cancer agents targeting the Ras/Raf/MEK/ERK Pathway. Recent Pat Anticancer Drug Discov. 4(1):28-35.

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MAPK signaling pathway I image by Aviva Systems Biology

MAPK signaling pathway II image by Aviva Systems Biology

 

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  • TRIAL 
    RELB antibody - middle region (P100787_P050) in Human THP-1 using Western Blot

    RELB antibody - middle region (P100787_P050)

    Protein Name:Transcription factor RelB
    Catalog #:P100787_P050
    Type: pAb
    Reacts with: Cow, Dog, Horse, Human, Mouse, Rabbit
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    Rapgef2 antibody - middle region (ARP42770_P050) in Mouse Kidney using Western Blot
    Rapgef2 antibody - middle region (ARP42770_P050) in Human sperm and mouse liver using Western Blot

    Rapgef2 antibody - middle region (ARP42770_P050)

    Protein Name:Rap guanine nucleotide exchange factor 2 Ensembl ENSMUSP00000113778
    Catalog #:ARP42770_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    RAP1B antibody - N-terminal region (ARP56194_P050) in Human PANC1 using Western Blot
    RAP1B antibody - N-terminal region (ARP56194_P050) in human heart using Immunohistochemistry

    RAP1B antibody - N-terminal region (ARP56194_P050)

    Protein Name:Ras-related protein Rap-1b
    Catalog #:ARP56194_P050
    Type: pAb
    Reacts with: Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB, IHC
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    RASGRP2 antibody - N-terminal region (ARP58820_P050) in Human Brain using Western Blot

    RASGRP2 antibody - N-terminal region (ARP58820_P050)

    Protein Name:RAS guanyl-releasing protein 2
    Catalog #:ARP58820_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    RPS6KA2 antibody - middle region (ARP56170_P050) in Human HepG2 using Western Blot

    RPS6KA2 antibody - middle region (ARP56170_P050)

    Protein Name:Ribosomal protein S6 kinase alpha-2
    Catalog #:ARP56170_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    RASGRF1 antibody - N-terminal region (ARP56516_P050) in HepG2 Cell  lysates using Western Blot
    RASGRF1 antibody - N-terminal region (ARP56516_P050) in Human Fetal Brain Cell  lysates using Western Blot
    RASGRF1 antibody - N-terminal region (ARP56516_P050) in Human Fetal Heart Cell  lysates using Western Blot
    RASGRF1 antibody - N-terminal region (ARP56516_P050) in Human Fetal Lung Cell  lysates using Western Blot

    RASGRF1 antibody - N-terminal region (ARP56516_P050)

    Protein Name:Ras-specific guanine nucleotide-releasing factor 1
    Catalog #:ARP56516_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    RAC1 antibody - middle region (ARP57798_P050) in Human HepG2 using Western Blot
    RAC1 antibody - middle region (ARP57798_P050) in siRUVBL1 transfected human H1299 using Western Blot

    RAC1 antibody - middle region (ARP57798_P050)

    Protein Name:Ras-related C3 botulinum toxin substrate 3
    Catalog #:ARP57798_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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