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MAPK Signaling Pathway

The Mitogen-activated protein kinase (MAPK) pathway is a cellular pathway consisting of a large number of proteins that can be activated by a variety of extracellular stimuli. Activation of the MAPK pathway can result in a multitude of physiological effects, including apoptosis, cell proliferation, mitosis, and the transcription of several classes of genes. Although the specific intermediates of the MAPK pathway can vary dramatically depending on physiological state, cell type, and stimuli, the classical MAPK pathway operates in the following general sequence: external growth factors bind to a transmembrane protein receptor and this signal is propagated through RAS and Raf intermediates prior to phosphorylating three or more MAPKs in sequence. The MAPK pathway’s ubiquitous nature ensures that this pathway mediates the vast majority of cellular responses.
Aberrant MAPK activity, including constitutive activation or down-regulation, can lead to continuous and unregulated cellular proliferation or muted responses to external stimuli. As a result of its potential influence on such a wide variety of cellular processes, including signal transduction, amplification, and proliferation, the MAPK signaling pathway has been implicated in a broad range of diseases ranging from cancer to obesity. For instance, in many cancers, constitutively active MAPK signaling pathway components such as Ras and Raf induce cell proliferation in the absence of appropriate signals. Raf mutations have been identified in melanomas, thyroid, colorectal, and ovarian cancers[1]. Current research is focused on creating and evaluating the efficacy of many downstream MAPK modulators and inhibitors.

1. Wong. 2009. Recent developments in anti-cancer agents targeting the Ras/Raf/MEK/ERK Pathway. Recent Pat Anticancer Drug Discov. 4(1):28-35.

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MAPK signaling pathway I image by Aviva Systems Biology

MAPK signaling pathway II image by Aviva Systems Biology

 

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  Type Catalog # Product Product Images Price (USD)
  pAb OASA08084 RABBIT ANTI HUMAN PDGF BB Antibody (0.1mg)
Reacts with
Application
ELISA, FN, WB
$495.00
  pAb OASA06415 RAC2 Antibody (OASA06415)
Reacts with
Human
Application
WB
$560.00
  pAb OASA08037 RELA Antibody (OASA08037)
Reacts with
Human
Application
ELISA, IHC-FFPE, WB
$415.00
  pAb P100787_P050 RELB antibody - middle region (P100787_P050)
Reacts with
Bovine, Dog, Horse, Human, Mouse, Rabbit
Application
WB
$289.00
  pAb ARP56194_P050 RAP1B antibody - N-terminal region (ARP56194_P050)
Reacts with
Human, Mouse, Dog, Zebrafish, Pig, Horse, Rat, Guinea pig, Goat, Bovine, Rabbit
Application
WB
$289.00
  pAb ARP58820_P050 RASGRP2 antibody - N-terminal region (ARP58820_P050)
Reacts with
Human, Dog, Guinea pig, Rat, Bovine, Rabbit, Mouse
Application
WB
$289.00
  pAb ARP56170_P050 RPS6KA2 antibody - middle region (ARP56170_P050)
Reacts with
Human, Dog, Rat, Pig, Horse, Guinea pig, Mouse, Bovine, Zebrafish, Rabbit
Application
WB
$289.00
  pAb ARP42770_P050 Rapgef2 antibody - middle region (ARP42770_P050)
Reacts with
Human, Mouse, Rat, Bovine, Dog, Pig, Horse, Rabbit, Guinea pig, Zebrafish
Application
WB
$289.00
  pAb ARP56516_P050 RASGRF1 antibody - N-terminal region (ARP56516_P050)
Reacts with
Human, Bovine, Dog, Pig, Rat, Guinea pig, Zebrafish, Horse, Rabbit, Mouse
Application
WB
$289.00
  pAb ARP57798_P050 RAC1 antibody - middle region (ARP57798_P050)
Reacts with
Mouse, Zebrafish, Human, Bovine, Sheep, Dog, Horse, Rabbit, Rat, Guinea pig
Application
WB
$289.00
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