MAPK Signaling Pathway

The Mitogen-activated protein kinase (MAPK) pathway is a cellular pathway consisting of a large number of proteins that can be activated by a variety of extracellular stimuli. Activation of the MAPK pathway can result in a multitude of physiological effects, including apoptosis, cell proliferation, mitosis, and the transcription of several classes of genes. Although the specific intermediates of the MAPK pathway can vary dramatically depending on physiological state, cell type, and stimuli, the classical MAPK pathway operates in the following general sequence: external growth factors bind to a transmembrane protein receptor and this signal is propagated through RAS and Raf intermediates prior to phosphorylating three or more MAPKs in sequence. The MAPK pathway’s ubiquitous nature ensures that this pathway mediates the vast majority of cellular responses.
Aberrant MAPK activity, including constitutive activation or down-regulation, can lead to continuous and unregulated cellular proliferation or muted responses to external stimuli. As a result of its potential influence on such a wide variety of cellular processes, including signal transduction, amplification, and proliferation, the MAPK signaling pathway has been implicated in a broad range of diseases ranging from cancer to obesity. For instance, in many cancers, constitutively active MAPK signaling pathway components such as Ras and Raf induce cell proliferation in the absence of appropriate signals. Raf mutations have been identified in melanomas, thyroid, colorectal, and ovarian cancers^[1]. Current research is focused on creating and evaluating the efficacy of many downstream MAPK modulators and inhibitors.

1. Wong. 2009. Recent developments in anti-cancer agents targeting the Ras/Raf/MEK/ERK Pathway. Recent Pat Anticancer Drug Discov. 4(1):28-35.

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Type	Catalog #	Product	Product Images	Price (USD)
Lysate	APL10439	CRK Protein Lysate (GST tagged) (Expressed in bacteria) (200ug) Reacts with Application		$219.00
pAb	ARP30523_P050	ARRB1 antibody - middle region (ARP30523_P050) Reacts with Dog, Horse, Human, Bovine Application WB	Human THP-1	$289.00
pAb	ARP30650_P050	MAP3K8 antibody - N-terminal region (ARP30650_P050) Reacts with Human, Horse, Mouse, Bovine Application WB	Human THP-1	$289.00
pAb	ARP32718_P050	NFKB2 antibody - N-terminal region (ARP32718_P050) Reacts with Bovine, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat, Chicken Application WB, IHC	Human Raji Human Lung	$289.00
pAb	ARP34952_P050	CACNA2D1 antibody - middle region (ARP34952_P050) Reacts with Bovine, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rat, Chicken Application WB	Human Muscle	$289.00
pAb	ARP34958_P050	CACNB3 antibody - N-terminal region (ARP34958_P050) Reacts with Human, Mouse, Pig, African clawed frog, Dog Application WB	Human Jurkat	$289.00
pAb	ARP35196_P050	Cacng3 antibody - C-terminal region (ARP35196_P050) Reacts with Dog, Pig, Chicken Application WB	Mouse Liver	$289.00
pAb	ARP35414_T100	CACNG6 antibody - N-terminal region (ARP35414_T100) Reacts with Human, Mouse, Dog Application WB	Human HepG2	$229.00
pAb	ARP35566_P050	CACNA1G antibody - C - terminal region (ARP35566_P050) Reacts with Dog, Horse, Human, Rabbit, Bovine, Guinea pig, Mouse, Pig, Rat Application WB, IHC	Human Spleen Human brain	$289.00
pAb	ARP36763_P050	CACNB4 antibody - middle region (ARP36763_P050) Reacts with Mouse, American bullfrog, Leiolepis reevesii rubritaeniata, Rat, Dog, Rabbit, Bovine, Sumatran orangutan, Pig, Guinea pig, Chicken, Duckbill platypus, Zebrafish, African clawed frog, Western clawed frog, Japanese pufferfish, Green puffer, Three-spined sti Application WB	Human MCF-7	$289.00
pAb	ARP36765_P050	CACNB2 antibody - N-terminal region (ARP36765_P050) Reacts with Human Application WB	Human HepG2	$289.00
pAb	ARP37106_T100	NFATC2 antibody - N-terminal region (ARP37106_T100) Reacts with Mouse, Horse, Human, Rat, Bovine, Dog, Pig Application WB	Mouse SP2/0	$229.00
pAb	ARP37668_P050	CACNG1 antibody - N-terminal region (ARP37668_P050) Reacts with Mouse, Rat, Dog Application WB	Human Fetal liver Human Jurkat	$289.00
pAb	ARP37694_T100	CACNG4 antibody - N-terminal region (ARP37694_T100) Reacts with Bovine, Chicken, Dog, Horse, Mouse Application WB	Human Jurkat	$229.00
pAb	ARP38493_P050	NFATC4 antibody - N-terminal region (ARP38493_P050) Reacts with Bovine, Dog, Guinea pig, Horse, Human, Pig, Rabbit, Rat Application WB	Human 721_B	$289.00
pAb	ARP38556_P050	PLA2G4B antibody - N-terminal region (ARP38556_P050) Reacts with Dog, Horse, Guinea pig, Mouse, Rat Application WB	Human 293T	$289.00
pAb	ARP38602_P050	JUND antibody - C-terminal region (ARP38602_P050) Reacts with Bovine, Dog, Guinea pig, Human, Mouse, Rat, Chicken, African clawed frog, Zebrafish Application WB	Human Placenta	$289.00
pAb	ARP41429_P050	PLA2G5 antibody - middle region (ARP41429_P050) Reacts with Dog, Bovine Application WB	Human Thymus	$289.00
pAb	ARP42065_P050	MAP2K3 antibody - C-terminal region (ARP42065_P050) Reacts with Bovine, Dog, Guinea pig, Horse, Human, Rabbit, Mouse, Rat, African clawed frog, Chicken Application WB	Human 721_B	$289.00
pAb	ARP42161_P050	MAP3K14 antibody - N-terminal region (ARP42161_P050) Reacts with Bovine, Dog, Horse, Mouse, Pig, Rabbit, Rat, Chicken Application WB		$289.00
pAb	ARP42224_P050	Fgf3 antibody - C-terminal region (ARP42224_P050) Reacts with African clawed frog, Bovine, Chicken, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rat, Zebrafish Application WB	Rat Liver	$289.00
pAb	ARP42770_P050	Rapgef2 antibody - middle region (ARP42770_P050) Reacts with African clawed frog, Bovine, Chicken, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Zebrafish Application WB	Mouse Kidney Human sperm and mouse liver	$289.00
pAb	ARP44743_T100	TGFBR2 antibody - N-terminal region (ARP44743_T100) Reacts with Human, Bovine, Mouse, Rat Application WB	Human HepG2	$229.00
pAb	ARP44901_P050	PTPN5 antibody - middle region (ARP44901_P050) Reacts with Bovine, Chicken, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish Application WB	Human HT1080	$289.00
pAb	ARP45387_P050	PTPRR antibody - C-terminal region (ARP45387_P050) Reacts with Bovine, Chicken, Dog, Guinea pig, Human, Mouse, Rabbit, Rat Application WB	Human Jurkat	$289.00
pAb	ARP45446_P050	TGFB2 antibody - middle region (ARP45446_P050) Reacts with Bovine, Dog, Human, Mouse, Pig, Rabbit, Rat, Sheep, African clawed frog, Guinea pig, Zebrafish, Chicken Application WB	Human NCI-H226	$289.00
pAb	ARP47041_P050	PLA2G2E antibody - middle region (ARP47041_P050) Reacts with Bovine, Mouse Application WB	Human Jurkat	$289.00
pAb	ARP48346_P050	GADD45B antibody - middle region (ARP48346_P050) Reacts with Dog, Rat Application WB	Human HepG2	$289.00
pAb	ARP48632_P050	MAP4K2 antibody - N-terminal region (ARP48632_P050) Reacts with Bovine, Horse, Human, Mouse, Rat, Dog, Pig, Guinea pig, Zebrafish Application WB	Human Liver	$289.00
pAb	ARP48684_P050	MAP3K1 antibody - C-terminal region (ARP48684_P050) Reacts with Bovine, Chicken, Dog, Guinea pig, Horse, Mouse, Pig, Rabbit, Rat Application WB	Human 721_B	$289.00

Aviva Systems Biology

MAPK Signaling Pathway

Reacts with

Application

Reacts with

Dog, Horse, Human, Bovine

Application

WB

Reacts with

Human, Horse, Mouse, Bovine

Application

WB

Reacts with

Bovine, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat, Chicken

Application

WB, IHC

Reacts with

Bovine, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rat, Chicken

Application

WB

Reacts with

Human, Mouse, Pig, African clawed frog, Dog

Application

WB

Reacts with

Dog, Pig, Chicken

Application

WB

Reacts with

Human, Mouse, Dog

Application

WB

Reacts with

Dog, Horse, Human, Rabbit, Bovine, Guinea pig, Mouse, Pig, Rat

Application

WB, IHC

Reacts with

Mouse, American bullfrog, Leiolepis reevesii rubritaeniata, Rat, Dog, Rabbit, Bovine, Sumatran orangutan, Pig, Guinea pig, Chicken, Duckbill platypus, Zebrafish, African clawed frog, Western clawed frog, Japanese pufferfish, Green puffer, Three-spined sti

Application

WB

Reacts with

Human

Application

WB

Reacts with

Mouse, Horse, Human, Rat, Bovine, Dog, Pig

Application

WB

Reacts with

Mouse, Rat, Dog

Application

WB

Reacts with

Bovine, Chicken, Dog, Horse, Mouse

Application

WB

Reacts with

Bovine, Dog, Guinea pig, Horse, Human, Pig, Rabbit, Rat

Application

WB

Reacts with

Dog, Horse, Guinea pig, Mouse, Rat

Application

WB

Reacts with

Bovine, Dog, Guinea pig, Human, Mouse, Rat, Chicken, African clawed frog, Zebrafish

Application

WB

Reacts with

Dog, Bovine

Application

WB

Reacts with

Bovine, Dog, Guinea pig, Horse, Human, Rabbit, Mouse, Rat, African clawed frog, Chicken

Application

WB

Reacts with

Bovine, Dog, Horse, Mouse, Pig, Rabbit, Rat, Chicken

Application

WB