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MAPK Signaling

The Mitogen-activated protein kinase (MAPK) pathway is a cellular pathway consisting of a large number of proteins that can be activated by a variety of extracellular stimuli. Activation of the MAPK pathway can result in a multitude of physiological effects, including apoptosis, cell proliferation, mitosis, and the transcription of several classes of genes. Although the specific intermediates of the MAPK pathway can vary dramatically depending on physiological state, cell type, and stimuli, the classical MAPK pathway operates in the following general sequence: external growth factors bind to a transmembrane protein receptor and this signal is propagated through RAS and Raf intermediates prior to phosphorylating three or more MAPKs in sequence. The MAPK pathway’s ubiquitous nature ensures that this pathway mediates the vast majority of cellular responses.
Aberrant MAPK activity, including constitutive activation or down-regulation, can lead to continuous and unregulated cellular proliferation or muted responses to external stimuli. As a result of its potential influence on such a wide variety of cellular processes, including signal transduction, amplification, and proliferation, the MAPK signaling pathway has been implicated in a broad range of diseases ranging from cancer to obesity. For instance, in many cancers, constitutively active MAPK signaling pathway components such as Ras and Raf induce cell proliferation in the absence of appropriate signals. Raf mutations have been identified in melanomas, thyroid, colorectal, and ovarian cancers[1]. Current research is focused on creating and evaluating the efficacy of many downstream MAPK modulators and inhibitors.

1. Wong. 2009. Recent developments in anti-cancer agents targeting the Ras/Raf/MEK/ERK Pathway. Recent Pat Anticancer Drug Discov. 4(1):28-35.

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MAPK signaling pathway I image by Aviva Systems Biology

MAPK signaling pathway II image by Aviva Systems Biology

 

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  •  
    Pdgfrb Antibody (OASA00464)

    Pdgfrb Antibody (OASA00464)

    Protein Name:Platelet-derived growth factor receptor beta
    Catalog #:OASA00464
    Type: mAb
    Reacts with:
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $545.00
  •  
    Ngf Antibody (OASA08467)

    Ngf Antibody (OASA08467)

    Protein Name:Beta-nerve growth factor
    Catalog #:OASA08467
    Type: pAb
    Reacts with: Mouse
    Application: WB
    Product Size: 0.1ml
    Price (USD): $545.00
  •  
    MAP3K7 Antibody (OASA06465)

    MAP3K7 Antibody (OASA06465)

    Protein Name:Mitogen-activated protein kinase kinase kinase 7
    Catalog #:OASA06465
    Type: pAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $530.00
  •  
    TRAF6 Antibody (OASA08876)

    TRAF6 Antibody (OASA08876)

    Protein Name:TNF receptor-associated factor 6
    Catalog #:OASA08876
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 0.1mg
    Price (USD): $310.00
  •  
    FGF4 Antibody (OASA07741)

    FGF4 Antibody (OASA07741)

    Protein Name:Fibroblast growth factor 4
    Catalog #:OASA07741
    Type: pAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $570.00
  •  
    NTRK1 Antibody (OASA03345)

    NTRK1 Antibody (OASA03345)

    Protein Name:High affinity nerve growth factor receptor
    Catalog #:OASA03345
    Type: mAb
    Reacts with:
    Application: IHC-AFF, IP
    Product Size: 0.2mg
    Price (USD): $560.00
  •  
    FGF7 Antibody (OASA07932)

    FGF7 Antibody (OASA07932)

    Protein Name:Fibroblast growth factor 7
    Catalog #:OASA07932
    Type: pAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $600.00
  •  
    SOS1 Antibody (OASA04400)

    SOS1 Antibody (OASA04400)

    Protein Name:Son of sevenless homolog 1
    Catalog #:OASA04400
    Type: mAb
    Reacts with: Human
    Application: ELISA, IF, WB
    Product Size: 0.1mg
    Price (USD): $270.00
  •  
    RELA Antibody (OASA08037)

    RELA Antibody (OASA08037)

    Protein Name:Transcription factor p65
    Catalog #:OASA08037
    Type: pAb
    Reacts with: Human
    Application: ELISA, IHC-FFPE, WB
    Product Size: 50ug
    Price (USD): $415.00
  •  
    FGF10 Antibody (OASA06164)

    FGF10 Antibody (OASA06164)

    Protein Name:Fibroblast growth factor 10
    Catalog #:OASA06164
    Type: pAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $570.00
  •  
    DUSP16 Antibody (OASA06350)

    DUSP16 Antibody (OASA06350)

    Protein Name:Dual specificity protein phosphatase 16
    Catalog #:OASA06350
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 0.1mg
    Price (USD): $560.00
  •  
    PDGFRA Antibody (OASA01243)

    PDGFRA Antibody (OASA01243)

    Protein Name:Platelet-derived growth factor receptor alpha
    Catalog #:OASA01243
    Type: mAb
    Reacts with: Human
    Application: ELISA, IHC-FFPE, WB
    Product Size: 0.1mg
    Price (USD): $485.00
  •  
    PAK2 antibody - C-terminal region (OASA08545)

    PAK2 antibody - C-terminal region (OASA08545)

    Protein Name:Serine/threonine-protein kinase PAK 2
    Catalog #:OASA08545
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 0.1mg
    Price (USD): $310.00
  •  
    PPP3CA Antibody (OASA07100)

    PPP3CA Antibody (OASA07100)

    Protein Name:Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
    Catalog #:OASA07100
    Type: pAb
    Reacts with:
    Application: IHC-AFF, WB
    Product Size: 0.1ml
    Price (USD): $1,615.00
  •  
    FGF2 Antibody (OASA02805)

    FGF2 Antibody (OASA02805)

    Protein Name:Fibroblast growth factor 2
    Catalog #:OASA02805
    Type: mAb
    Reacts with: Human
    Application: IHC-AFF, ELISA
    Product Size: 0.5mg
    Price (USD): $440.00

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Showing 1 - 30 of 160