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MAPK Signaling

The Mitogen-activated protein kinase (MAPK) pathway is a cellular pathway consisting of a large number of proteins that can be activated by a variety of extracellular stimuli. Activation of the MAPK pathway can result in a multitude of physiological effects, including apoptosis, cell proliferation, mitosis, and the transcription of several classes of genes. Although the specific intermediates of the MAPK pathway can vary dramatically depending on physiological state, cell type, and stimuli, the classical MAPK pathway operates in the following general sequence: external growth factors bind to a transmembrane protein receptor and this signal is propagated through RAS and Raf intermediates prior to phosphorylating three or more MAPKs in sequence. The MAPK pathway’s ubiquitous nature ensures that this pathway mediates the vast majority of cellular responses.
Aberrant MAPK activity, including constitutive activation or down-regulation, can lead to continuous and unregulated cellular proliferation or muted responses to external stimuli. As a result of its potential influence on such a wide variety of cellular processes, including signal transduction, amplification, and proliferation, the MAPK signaling pathway has been implicated in a broad range of diseases ranging from cancer to obesity. For instance, in many cancers, constitutively active MAPK signaling pathway components such as Ras and Raf induce cell proliferation in the absence of appropriate signals. Raf mutations have been identified in melanomas, thyroid, colorectal, and ovarian cancers[1]. Current research is focused on creating and evaluating the efficacy of many downstream MAPK modulators and inhibitors.

1. Wong. 2009. Recent developments in anti-cancer agents targeting the Ras/Raf/MEK/ERK Pathway. Recent Pat Anticancer Drug Discov. 4(1):28-35.

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MAPK signaling pathway I image by Aviva Systems Biology

MAPK signaling pathway II image by Aviva Systems Biology

 

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    Prkar1a Antibody (OASA08703)

    Prkar1a Antibody (OASA08703)

    Protein Name:cAMP-dependent protein kinase type I-alpha regulatory subunit
    Catalog #:OASA08703
    Type: pAb
    Reacts with: Rat
    Application: WB
    Product Size: 0.1mg
    Price (USD): $760.00
  •  
    TNF Antibody (OASA07352)

    TNF Antibody (OASA07352)

    Protein Name:Tumor necrosis factor
    Catalog #:OASA07352
    Type: pAb
    Reacts with: Horse
    Application: ELISA, WB
    Product Size: 0.5mg
    Price (USD): $600.00
  •  
    HSPA1A Antibody (OASA02855)

    HSPA1A Antibody (OASA02855)

    Protein Name:Heat shock 70 kDa protein 1A/1B
    Catalog #:OASA02855
    Type: mAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $430.00
  •  
    Pdgfrb Antibody (OASA00464)

    Pdgfrb Antibody (OASA00464)

    Protein Name:Platelet-derived growth factor receptor beta
    Catalog #:OASA00464
    Type: mAb
    Reacts with:
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $545.00
  •  
    Ngf Antibody (OASA08467)

    Ngf Antibody (OASA08467)

    Protein Name:Beta-nerve growth factor
    Catalog #:OASA08467
    Type: pAb
    Reacts with: Mouse
    Application: WB
    Product Size: 0.1ml
    Price (USD): $545.00
  •  
    MAP3K7 Antibody (OASA06465)

    MAP3K7 Antibody (OASA06465)

    Protein Name:Mitogen-activated protein kinase kinase kinase 7
    Catalog #:OASA06465
    Type: pAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $530.00
  •  
    TRAF6 Antibody (OASA08876)

    TRAF6 Antibody (OASA08876)

    Protein Name:TNF receptor-associated factor 6
    Catalog #:OASA08876
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 0.1mg
    Price (USD): $310.00
  •  
    FGF4 Antibody (OASA07741)

    FGF4 Antibody (OASA07741)

    Protein Name:Fibroblast growth factor 4
    Catalog #:OASA07741
    Type: pAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $570.00
  •  
    NTRK1 Antibody (OASA03345)

    NTRK1 Antibody (OASA03345)

    Protein Name:High affinity nerve growth factor receptor
    Catalog #:OASA03345
    Type: mAb
    Reacts with:
    Application: IHC-AFF, IP
    Product Size: 0.2mg
    Price (USD): $560.00
  •  
    FGF7 Antibody (OASA07932)

    FGF7 Antibody (OASA07932)

    Protein Name:Fibroblast growth factor 7
    Catalog #:OASA07932
    Type: pAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $600.00
  •  
    SOS1 Antibody (OASA04400)

    SOS1 Antibody (OASA04400)

    Protein Name:Son of sevenless homolog 1
    Catalog #:OASA04400
    Type: mAb
    Reacts with: Human
    Application: ELISA, IF, WB
    Product Size: 0.1mg
    Price (USD): $270.00
  •  
    RELA Antibody (OASA08037)

    RELA Antibody (OASA08037)

    Protein Name:Transcription factor p65
    Catalog #:OASA08037
    Type: pAb
    Reacts with: Human
    Application: ELISA, IHC-FFPE, WB
    Product Size: 50ug
    Price (USD): $415.00

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