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MAPK Signaling

The Mitogen-activated protein kinase (MAPK) pathway is a cellular pathway consisting of a large number of proteins that can be activated by a variety of extracellular stimuli. Activation of the MAPK pathway can result in a multitude of physiological effects, including apoptosis, cell proliferation, mitosis, and the transcription of several classes of genes. Although the specific intermediates of the MAPK pathway can vary dramatically depending on physiological state, cell type, and stimuli, the classical MAPK pathway operates in the following general sequence: external growth factors bind to a transmembrane protein receptor and this signal is propagated through RAS and Raf intermediates prior to phosphorylating three or more MAPKs in sequence. The MAPK pathway’s ubiquitous nature ensures that this pathway mediates the vast majority of cellular responses.
Aberrant MAPK activity, including constitutive activation or down-regulation, can lead to continuous and unregulated cellular proliferation or muted responses to external stimuli. As a result of its potential influence on such a wide variety of cellular processes, including signal transduction, amplification, and proliferation, the MAPK signaling pathway has been implicated in a broad range of diseases ranging from cancer to obesity. For instance, in many cancers, constitutively active MAPK signaling pathway components such as Ras and Raf induce cell proliferation in the absence of appropriate signals. Raf mutations have been identified in melanomas, thyroid, colorectal, and ovarian cancers[1]. Current research is focused on creating and evaluating the efficacy of many downstream MAPK modulators and inhibitors.

1. Wong. 2009. Recent developments in anti-cancer agents targeting the Ras/Raf/MEK/ERK Pathway. Recent Pat Anticancer Drug Discov. 4(1):28-35.

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MAPK signaling pathway I image by Aviva Systems Biology

MAPK signaling pathway II image by Aviva Systems Biology

 

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    Map2k5 Antibody (OASA08684)

    Map2k5 Antibody (OASA08684)

    Protein Name:Dual specificity mitogen-activated protein kinase kinase 5
    Catalog #:OASA08684
    Type: pAb
    Reacts with: Rat
    Application: WB
    Product Size: 0.1ml
    Price (USD): $450.00
  •  
    Egf Antibody (OASA06527)

    Egf Antibody (OASA06527)

    Protein Name:Pro-epidermal growth factor
    Catalog #:OASA06527
    Type: pAb
    Reacts with: Mouse
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $570.00
  •  
    HSPB1 Antibody (OASA02851)

    HSPB1 Antibody (OASA02851)

    Protein Name:Heat shock protein beta-1
    Catalog #:OASA02851
    Type: mAb
    Reacts with: Human
    Application: IHC-AFF, IHC-FFPE, WB
    Product Size: 1ml
    Price (USD): $1,055.00
  •  
    Mapk3 Antibody (OASA07240)

    Mapk3 Antibody (OASA07240)

    Protein Name:Mitogen-activated protein kinase 3
    Catalog #:OASA07240
    Type: pAb
    Reacts with: Rat
    Application: WB
    Product Size: 0.1ml
    Price (USD): $725.00
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    RABBIT ANTI HUMAN FGF ACIDIC Antibody

    RABBIT ANTI HUMAN FGF ACIDIC Antibody

    Protein Name:Fibroblast growth factor 1
    Catalog #:OASA07743
    Type: pAb
    Reacts with:
    Application: ELISA, FN, WB
    Product Size: 0.1mg
    Price (USD): $500.00
  •  
    TGFB1 Antibody (OASA04458)

    TGFB1 Antibody (OASA04458)

    Protein Name:Transforming growth factor beta-1
    Catalog #:OASA04458
    Type: mAb
    Reacts with: Cow, Human, Mouse
    Application: ELISA, IHC-FFPE, WB
    Product Size: 0.1mg
    Price (USD): $590.00
  •  
    MAP2K1 Antibody (OASA07970)

    MAP2K1 Antibody (OASA07970)

    Protein Name:Dual specificity mitogen-activated protein kinase kinase 1
    Catalog #:OASA07970
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 50ug
    Price (USD): $455.00
  •  
    ATF4 Antibody (OASA06042)

    ATF4 Antibody (OASA06042)

    Protein Name:Cyclic AMP-dependent transcription factor ATF-4
    Catalog #:OASA06042
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 0.1mg
    Price (USD): $400.00
  •  
    NTF4 Antibody (OASA08047)

    NTF4 Antibody (OASA08047)

    Protein Name:Neurotrophin-4
    Catalog #:OASA08047
    Type: pAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $570.00
  •  
    Fgf9 Antibody (OASA08392)

    Fgf9 Antibody (OASA08392)

    Protein Name:Fibroblast growth factor 9
    Catalog #:OASA08392
    Type: pAb
    Reacts with: Mouse
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $570.00
  •  
    FGF21 Antibody (OASA06166)

    FGF21 Antibody (OASA06166)

    Protein Name:Fibroblast growth factor 21
    Catalog #:OASA06166
    Type: pAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $530.00
  •  
    PRKAR2A Antibody (OASA00363)

    PRKAR2A Antibody (OASA00363)

    Protein Name:cAMP-dependent protein kinase type II-alpha regulatory subunit
    Catalog #:OASA00363
    Type: mAb
    Reacts with: Cow
    Application: ELISA, IF
    Product Size: 0.2mg
    Price (USD): $365.00
  •  
    BDNF Antibody (OASA07456)

    BDNF Antibody (OASA07456)

    Protein Name:Brain-derived neurotrophic factor
    Catalog #:OASA07456
    Type: pAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $570.00
  •  
    PRKCB Antibody (OASA03763)

    PRKCB Antibody (OASA03763)

    Protein Name:Protein kinase C beta type
    Catalog #:OASA03763
    Type: mAb
    Reacts with:
    Application: IHC-AFF
    Product Size: 2ml
    Price (USD): $455.00
  •  
    IKBKG Antibody (OASA07841)

    IKBKG Antibody (OASA07841)

    Protein Name:NF-kappa-B essential modulator
    Catalog #:OASA07841
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 0.1mg
    Price (USD): $355.00
  •  
    GOAT ANTI HUMAN AKT3 (aa119-133) Antibody

    GOAT ANTI HUMAN AKT3 (aa119-133) Antibody

    Protein Name:RAC-gamma serine/threonine-protein kinase
    Catalog #:OASA06009
    Type: pAb
    Reacts with:
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $460.00
  •  
    NFKB1 Antibody (OASA08036)

    NFKB1 Antibody (OASA08036)

    Protein Name:Nuclear factor NF-kappa-B p105 subunit
    Catalog #:OASA08036
    Type: pAb
    Reacts with: Human
    Application: ELISA, GS, IP, WB
    Product Size: 0.1ml
    Price (USD): $750.00
  •  
    RPS6KA1 Antibody (OASA08149)

    RPS6KA1 Antibody (OASA08149)

    Protein Name:Ribosomal protein S6 kinase alpha-1
    Catalog #:OASA08149
    Type: pAb
    Reacts with: Human
    Application: IHC-AFF, WB
    Product Size: 0.1mg
    Price (USD): $355.00

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Showing 1 - 30 of 160