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JAK-STAT Pathway

The Janus Kinase (Jak)- Signal Transducer and Activator of Transcription (STAT) signaling pathway converts extracellular signals into intracellular action such as cell migration, proliferation, and differentiation. Jak-STAT signaling is an evolutionarily conserved process that allows a cell to respond to a variety of growth and survival signals. There are three critical components of the Jak-STAT signaling pathway: a cytokine receptor, Jak, and STAT.

During Jak-STAT signaling, Jak will bind to a transmembrane cytokine receptor, which, upon ligand binding, will cause Jak to autophosphorylate. Jak phosphorylation encourages the recruitment of STAT molecules that are, in turn, phosphorylated by Jak. STAT molecules then form hetero- or homodimers and translocate to the nucleus to initiate transcription. There are seven different STAT molecules that interact with unique DNA sequences. Activation of Jaks associated with membrane receptors can also act as docking stations for secondary signaling molecules and adaptors that can link the Jak-STAT pathway to MAPK and other signaling pathways. Suppressors of cytokine signaling (SOCS) that compete with STAT binding sites on receptors and protein inhibitors of activated STAT (PIAS) that inhibit STAT binding to DNA negatively regulate the Jak-STAT pathway.

Jak mutations are hallmarks of many haematological malignancies. For instance, mutations in Jak3 that render it constitutively active can cause acute megakaryoblastic leukemia[1]. Similarly, STAT3, which is phosphorylated during IL-6 signaling, can be oncogenic if not properly controlled; STAT3 dysregulation, therefore, can continually promote an anti-apoptotic cellular milieu[2]. Considering the impact of dysregulated Jak-STAT signaling in a variety of diseases, including inflammatory disorders and malignancies, they are currently the focus of therapeutic intervention.  

1. Walters et al. 2006. Activating alleles of JAK3 in acute megakaryoblastic leukemia. Cancer Cell. 10(1):65-75.
2. Sun et al. 2011. Inhibition of Stat3 activation by sanguinarine suppresses prostate cancer cell growth and invasion. Prostate. [epub ahead of print].

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Showing 91 - 105 of 105
  • TRIAL 
    SPRY3 antibody - N-terminal region (ARP50519_P050) in Human Brain using Western Blot

    SPRY3 antibody - N-terminal region (ARP50519_P050)

    Protein Name:Protein sprouty homolog 3
    Catalog #:ARP50519_P050
    Type: pAb
    Reacts with: Cow, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    PIK3CB antibody - C-terminal region (ARP32117_T100) in Human Brain using Western Blot

    PIK3CB antibody - C-terminal region (ARP32117_T100)

    Protein Name:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
    Catalog #:ARP32117_T100
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $229.00
  •  
    IL22RA1 antibody - N-terminal region (OASA06289) in human spleen using Immunohistochemistry
    IL22RA1 antibody - N-terminal region (OASA06289) in Human tonsil using Immunohistochemistry

    IL22RA1 antibody - N-terminal region (OASA06289)

    Protein Name:Interleukin-22 receptor subunit alpha-1
    Catalog #:OASA06289
    Type: pAb
    Reacts with: Human
    Application: ELISA, IF, IHC-FFPE
    Product Size: 0.1mg
    Price (USD): $455.00
  • TRIAL 
    PIM1 antibody - N-terminal region (ARP56390_P050) in Human 293T using Western Blot

    PIM1 antibody - N-terminal region (ARP56390_P050)

    Protein Name:Serine/threonine-protein kinase pim-1
    Catalog #:ARP56390_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    SOCS7 antibody - N-terminal region (ARP53700_P050) in Human OVCAR-3 using Western Blot

    SOCS7 antibody - N-terminal region (ARP53700_P050)

    Protein Name:Suppressor of cytokine signaling 7
    Catalog #:ARP53700_P050
    Type: pAb
    Reacts with: Cow, Human, Mouse, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    IL11RA antibody - N-terminal region (ARP46466_P050) in Human Jurkat using Western Blot

    IL11RA antibody - N-terminal region (ARP46466_P050)

    Protein Name:Interleukin-11 receptor subunit alpha
    Catalog #:ARP46466_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    SPRY4 antibody - middle region (ARP50697_P050) in Human HeLa using Western Blot

    SPRY4 antibody - middle region (ARP50697_P050)

    Protein Name:Protein sprouty homolog 4
    Catalog #:ARP50697_P050
    Type: pAb
    Reacts with: Cow, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    IL23R antibody - N-terminal region (OASA06290) in human spleen using Immunohistochemistry
    IL23R antibody - N-terminal region (OASA06290) in human spleen using Immunohistochemistry

    IL23R antibody - N-terminal region (OASA06290)

    Protein Name:Interleukin-23 receptor
    Catalog #:OASA06290
    Type: pAb
    Reacts with: Human
    Application: IHC-FFPE, WB
    Product Size: 0.1mg
    Price (USD): $440.00
  •  
    IFNGR1 Antibody (OASA01137) in human peripheral blood monocytes using Flow Cytometry
    IFNGR1 Antibody (OASA01137) in human peripheral blood monocytes using Flow Cytometry

    IFNGR1 Antibody (OASA01137)

    Protein Name:Interferon gamma receptor 1
    Catalog #:OASA01137
    Type: mAb
    Reacts with: Human
    Application: IHC-AFF, ELISA, FC, WB
    Product Size: 0.2mg
    Price (USD): $495.00
  • TRIAL 
    PIAS1 antibody - middle region (ARP39232_P050) in Human COLO205 using Western Blot
    PIAS1 antibody - middle region (ARP39232_P050) in Human  U251 using Western Blot

    PIAS1 antibody - middle region (ARP39232_P050)

    Protein Name:E3 SUMO-protein ligase PIAS1
    Catalog #:ARP39232_P050
    Type: pAb
    Reacts with: Cow, Dog, Horse, Human
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    CNTFR antibody - C-terminal region (ARP59996_P050) in Human HepG2 using Western Blot
    CNTFR antibody - C-terminal region (ARP59996_P050) in Human A549, H441 using Western Blot

    CNTFR antibody - C-terminal region (ARP59996_P050)

    Protein Name:Ciliary neurotrophic factor receptor subunit alpha
    Catalog #:ARP59996_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    STAT5B antibody - C-terminal region (ARP39001_P050) in Human Fetal Brain using Western Blot
    STAT5B antibody - C-terminal region (ARP39001_P050) in  using Immunohistochemistry
    STAT5B antibody - C-terminal region (ARP39001_P050) in  using Immunohistochemistry

    STAT5B antibody - C-terminal region (ARP39001_P050)

    Protein Name:Signal transducer and activator of transcription 5B
    Catalog #:ARP39001_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: IHC, WB
    Product Size: 100 ul
    Price (USD): $289.00

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Showing 91 - 105 of 105