TYK2 antibody - C-terminal region (ARP30319_P050)

Catalog#: ARP30319_P050

• Size: 50ug

Human COLO205

• Description of Target: This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
• Gene Symbol: TYK2
• Official Gene Full Name: Tyrosine kinase 2
• Alias Symbols: JTK1
• Protein Accession#: NP_003322
• Nucleotide Accession#: NM_003331
• Swissprot Id: P29597
• Host: Rabbit
• Clonality: Polyclonal
• Protein Size (# AA): 1187
• Molecular Weight: 134kDa
• Application: WB
• Partner Proteins: GNB2L1, IFNAR2, IL12RB1, JAKMIP1, CBL, CRKL, EIF2AK2, FYN, GHR, GNB2L1, IFNAR2, IL13RA1, IL6ST, IRS1, IRS2, JAK1, JAKMIP1, LYN, PDGFRB, PIK3R1, PLAUR, PRMT5, PTAFR, PTPN1, PTPN6, PTPRC, STAM2, STAT1, STAT2, TYK2, VAV1, XRCC5, CBL, CRKL, ELP2, FYN, GHR, GNB2L1, IFNAR1, IL13RA1, IL6ST, IRS2, JAK1, LYN, PLAUR, PRMT5, PTPN1, PTPN6, STAM2, STAT1, TYK2, VAV1, XRCC5
• Immunogen: The immunogen for anti-TYK2 antibody: synthetic peptide directed towards the C terminal of human TYK2
• Product Format: Lyophilized powder
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: African clawed frog: 100%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Bovine: 90%; Guinea pig: 90%
• Peptide Sequence: Synthetic peptide located within the following region: HRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAP
• Blocking Peptide: For anti-TYK2 antibody is Catalog # AAP30319 (Previous Catalog # AAPS08805)
• Key Reference: N/A
• Reconstitution and Storage: Add 50 μl of distilled water. Final anti-TYK2 antibody concentration is 1 mg/ml in PBS buffer. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.

Product Protocols: TYK2 antibody tested with Human Colo205 Cells (ARP30319_P050)

Aviva Systems Biology is the original manufacturer of this TYK2 antibody (ARP30319_P050)

Click here to view the TYK2 antibody Western Blot Protocol

Product Datasheet Link: TYK2 antibody (ARP30319_P050)

WB Suggested Anti-TYK2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: COLO205

Western Blot image:


Description of Target: This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.

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Aviva Systems Biology’s TYK2 antibody (ARP30319_P050) has been tested using other cell lysates and tissues. To obtain more data about this antibody please email us at info@avivasysbio.com.

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