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JAK-STAT Pathway

The Janus Kinase (Jak)- Signal Transducer and Activator of Transcription (STAT) signaling pathway converts extracellular signals into intracellular action such as cell migration, proliferation, and differentiation. Jak-STAT signaling is an evolutionarily conserved process that allows a cell to respond to a variety of growth and survival signals. There are three critical components of the Jak-STAT signaling pathway: a cytokine receptor, Jak, and STAT.

During Jak-STAT signaling, Jak will bind to a transmembrane cytokine receptor, which, upon ligand binding, will cause Jak to autophosphorylate. Jak phosphorylation encourages the recruitment of STAT molecules that are, in turn, phosphorylated by Jak. STAT molecules then form hetero- or homodimers and translocate to the nucleus to initiate transcription. There are seven different STAT molecules that interact with unique DNA sequences. Activation of Jaks associated with membrane receptors can also act as docking stations for secondary signaling molecules and adaptors that can link the Jak-STAT pathway to MAPK and other signaling pathways. Suppressors of cytokine signaling (SOCS) that compete with STAT binding sites on receptors and protein inhibitors of activated STAT (PIAS) that inhibit STAT binding to DNA negatively regulate the Jak-STAT pathway.

Jak mutations are hallmarks of many haematological malignancies. For instance, mutations in Jak3 that render it constitutively active can cause acute megakaryoblastic leukemia[1]. Similarly, STAT3, which is phosphorylated during IL-6 signaling, can be oncogenic if not properly controlled; STAT3 dysregulation, therefore, can continually promote an anti-apoptotic cellular milieu[2]. Considering the impact of dysregulated Jak-STAT signaling in a variety of diseases, including inflammatory disorders and malignancies, they are currently the focus of therapeutic intervention.  

1. Walters et al. 2006. Activating alleles of JAK3 in acute megakaryoblastic leukemia. Cancer Cell. 10(1):65-75.
2. Sun et al. 2011. Inhibition of Stat3 activation by sanguinarine suppresses prostate cancer cell growth and invasion. Prostate. [epub ahead of print].

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  Type Catalog # Product Product Images Price (USD)
  Protein OPSA11093 MOUSE INTERFERON BETA Recombinant Protein (100000UNITS/0.1ml)
Reacts with
Mouse
Application
$840.00
  Protein OPSA11104 MOUSE INTERLEUKIN-12 Recombinant Protein (10ug)
Reacts with
Mouse
Application
$615.00
  Protein OPSA10992 HUMAN INTERFERON ALPHA A Recombinant Protein (5x10*6UNITS/0.1ml)
Reacts with
Human
Application
$415.00
  pAb OASA06961 AKT1 antibody - N-terminal region (OASA06961)
Reacts with
Human
Application
WB
$310.00
  mAb OASA01131 CSF2RA Antibody (OASA01131)
Reacts with
Human
Application
IHC-AFF, FC, IP, WB
$130.00
  pAb OASA07889 IL23A antibody - C-terminal region (OASA07889)
Reacts with
Human
Application
IHC-AFF, WB
$445.00
  mAb OASA02761 EPO Antibody (OASA02761)
Reacts with
Human
Application
ELISA
$440.00
  pAb OASA08255 CRLF2 Antibody (OASA08255)
Reacts with
Human
Application
WB
$365.00
  mAb OASA03292 SOCS3 Antibody (OASA03292)
Reacts with
Human
Application
ELISA, WB
$300.00
  pAb OASA08664 Gh1 Antibody (OASA08664)
Reacts with
Rat
Application
IHC-AFF, WB
$515.00
  mAb OASA03709 IFNA1 Antibody (OASA03709)
Reacts with
Pig
Application
ELISA, WB
$720.00
  mAb OASA05092 Il2ra Antibody (OASA05092)
Reacts with
Mouse
Application
IHC-AFF, FC, IP
$345.00
  mAb OASA00738 Ghr Antibody (OASA00738)
Reacts with
Application
IHC-AFF, FC, IP, IHC-FFPE
$530.00
  pAb OASA06660 Il12b Antibody (OASA06660)
Reacts with
Mouse
Application
ELISA, WB
$570.00
  pAb OASA07643 CREBBP Antibody (OASA07643)
Reacts with
Human
Application
IP, WB
$640.00
  mAb OASA01196 IL6ST Antibody (OASA01196)
Reacts with
Human
Application
ELISA, FC
$485.00
  pAb OASA08104 PIK3CD antibody - C-terminal region (OASA08104)
Reacts with
Human
Application
ELISA, WB
$455.00
  mAb OASA03006 IL4R Antibody (OASA03006)
Reacts with
Human
Application
ELISA, FC, IHC-FFPE, WB
$600.00
  pAb OASA08443 Il7 Antibody (OASA08443)
Reacts with
Mouse
Application
ELISA, WB
$555.00
  pAb OASA09262 PRLR Antibody (OASA09262)
Reacts with
Human
Application
ELISA, WB
$255.00
  mAb OASA04869 Il3ra Antibody (OASA04869)
Reacts with
Mouse
Application
FC
$355.00
  mAb OASA05650 Il6 Antibody (OASA05650)
Reacts with
Mouse
Application
ELISA
$695.00
  pAb OASA06331 LEPR Antibody (OASA06331)
Reacts with
Human
Application
ELISA, WB
$515.00
  pAb OASA07028 BCL2L1 Antibody (OASA07028)
Reacts with
Human
Application
IHC-FFPE, WB
$410.00
  pAb OASA08053 OSM Antibody (OASA08053)
Reacts with
Human
Application
ELISA, WB
$570.00
  mAb OASA02842 GRB2 Antibody (OASA02842)
Reacts with
Human
Application
WB
$410.00
  pAb OASA08399 Csf3 Antibody (OASA08399)
Reacts with
Mouse
Application
ELISA, WB
$555.00
  mAb OASA03325 TPO Antibody (OASA03325)
Reacts with
Human
Application
ELISA, WB
$440.00
  pAb OASA08671 Il2 Antibody (OASA08671)
Reacts with
Rat
Application
ELISA, WB
$555.00
  mAb OASA04400 SOS1 Antibody (OASA04400)
Reacts with
Human
Application
ELISA, IF, WB
$270.00

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