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JAK-STAT Pathway

The Janus Kinase (Jak)- Signal Transducer and Activator of Transcription (STAT) signaling pathway converts extracellular signals into intracellular action such as cell migration, proliferation, and differentiation. Jak-STAT signaling is an evolutionarily conserved process that allows a cell to respond to a variety of growth and survival signals. There are three critical components of the Jak-STAT signaling pathway: a cytokine receptor, Jak, and STAT.

During Jak-STAT signaling, Jak will bind to a transmembrane cytokine receptor, which, upon ligand binding, will cause Jak to autophosphorylate. Jak phosphorylation encourages the recruitment of STAT molecules that are, in turn, phosphorylated by Jak. STAT molecules then form hetero- or homodimers and translocate to the nucleus to initiate transcription. There are seven different STAT molecules that interact with unique DNA sequences. Activation of Jaks associated with membrane receptors can also act as docking stations for secondary signaling molecules and adaptors that can link the Jak-STAT pathway to MAPK and other signaling pathways. Suppressors of cytokine signaling (SOCS) that compete with STAT binding sites on receptors and protein inhibitors of activated STAT (PIAS) that inhibit STAT binding to DNA negatively regulate the Jak-STAT pathway.

Jak mutations are hallmarks of many haematological malignancies. For instance, mutations in Jak3 that render it constitutively active can cause acute megakaryoblastic leukemia[1]. Similarly, STAT3, which is phosphorylated during IL-6 signaling, can be oncogenic if not properly controlled; STAT3 dysregulation, therefore, can continually promote an anti-apoptotic cellular milieu[2]. Considering the impact of dysregulated Jak-STAT signaling in a variety of diseases, including inflammatory disorders and malignancies, they are currently the focus of therapeutic intervention.  

1. Walters et al. 2006. Activating alleles of JAK3 in acute megakaryoblastic leukemia. Cancer Cell. 10(1):65-75.
2. Sun et al. 2011. Inhibition of Stat3 activation by sanguinarine suppresses prostate cancer cell growth and invasion. Prostate. [epub ahead of print].

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Showing 1 - 30 of 83
  Type Catalog # Product Product Images Price (USD)
  pAb ARP30319_P050 TYK2 antibody - C-terminal region (ARP30319_P050)
Reacts with
Human, Rat, Mouse, Dog, Horse, Bovine, Guinea pig
Application
WB
$289.00
  pAb ARP32117_T100 PIK3CB antibody - C-terminal region (ARP32117_T100)
Reacts with
Mouse, Human, Dog, Zebrafish, Rat, Bovine, Horse, Rabbit, Guinea pig
Application
WB
$229.00
  pAb ARP32763_P050 PIAS3 antibody - middle region (ARP32763_P050)
Reacts with
Human, Dog, Horse, Guinea pig, Bovine, Rabbit, Rat
Application
WB
$289.00
  pAb ARP33011_P050 PIAS4 antibody - N-terminal region (ARP33011_P050)
Reacts with
Bovine, Human, Rat, Mouse, Dog, Horse, Guinea pig, Zebrafish
Application
WB
$289.00
  pAb ARP38256_P050 STAT5A antibody - C-terminal region (ARP38256_P050)
Reacts with
Human, Dog, Pig, Bovine, Horse, Goat, Sheep, Rat, Mouse, Rabbit, Guinea pig
Application
WB
$289.00
  pAb ARP39001_P050 STAT5B antibody - C-terminal region (ARP39001_P050)
Reacts with
Rabbit, Rat, Guinea pig, Mouse, Human, Horse, Zebrafish, Dog, Bovine
Application
IHC, WB
$289.00
  pAb ARP39232_P050 PIAS1 antibody - middle region (ARP39232_P050)
Reacts with
Human, Dog, Horse, Bovine
Application
WB
$289.00
  pAb ARP46396_P050 OSMR antibody - middle region (ARP46396_P050)
Reacts with
Human, Dog, Horse, Guinea pig, Rabbit
Application
WB
$289.00
  pAb ARP46466_P050 IL11RA antibody - N-terminal region (ARP46466_P050)
Reacts with
Dog, Pig, Horse, Rabbit, Human, Guinea pig, Mouse, Bovine, Rat
Application
WB
$289.00
  pAb ARP46611_P050 IFNGR2 antibody - middle region (ARP46611_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP48070_P050 IL28RA antibody - N-terminal region (ARP48070_P050)
Reacts with
Human, Rat, Pig, Horse, Rabbit, Bovine
Application
WB
$289.00
  pAb ARP50519_P050 SPRY3 antibody - N-terminal region (ARP50519_P050)
Reacts with
Rat, Bovine, Pig, Horse, Rabbit, Guinea pig, Human, Mouse
Application
WB
$289.00
  pAb ARP50697_P050 SPRY4 antibody - middle region (ARP50697_P050)
Reacts with
Human, Bovine, Pig, Horse, Rabbit, Guinea pig, Mouse, Rat
Application
WB
$289.00
  pAb ARP53558_P050 IL13RA2 antibody - middle region (ARP53558_P050)
Reacts with
Human, Rabbit, Rat
Application
WB
$289.00
  pAb ARP53700_P050 SOCS7 antibody - N-terminal region (ARP53700_P050)
Reacts with
Rat, Bovine, Pig, Rabbit, Human, Mouse
Application
WB
$289.00
  pAb ARP53840_P050 PIAS2 antibody - N-terminal region (ARP53840_P050)
Reacts with
Human, Rat, Bovine, Pig, Dog, Horse, Mouse, Rabbit, Guinea pig
Application
WB
$289.00
  pAb ARP54331_P050 IL9 antibody - middle region (ARP54331_P050)
Reacts with
Human, Rat, Horse, Guinea pig
Application
WB
$289.00
  pAb ARP54652_P050 IFNA5 antibody - middle region (ARP54652_P050)
Reacts with
Human, Guinea pig, Horse, Rat, Mouse
Application
WB
$289.00
  pAb ARP55373_P050 IFNA7 antibody - N-terminal region (ARP55373_P050)
Reacts with
Human, Pig, Guinea pig, Mouse
Application
WB
$289.00
  pAb ARP56390_P050 PIM1 antibody - N-terminal region (ARP56390_P050)
Reacts with
Sheep, Dog, Horse, Mouse, Rabbit, Human, Rat, Bovine, Pig, Guinea pig
Application
WB
$289.00
  pAb ARP59996_P050 CNTFR antibody - C-terminal region (ARP59996_P050)
Reacts with
Human, Bovine, Pig, Horse, Rabbit, Rat, Sheep, Guinea pig, Mouse, Dog
Application
WB
$289.00
  pAb ARP60369_P050 SPRED2 antibody - C-terminal region (ARP60369_P050)
Reacts with
Human, Bovine, Pig, Rabbit, Rat, Guinea pig, Mouse, Horse, Dog, Zebrafish
Application
WB
$289.00
  pAb AVARP02063_P050 AKT2 antibody - N-terminal region (AVARP02063_P050)
Reacts with
Bovine, Dog, Horse, Human, Mouse, Pig, Rat
Application
WB
$289.00
  mAb OASA00538 MYC Antibody (OASA00538)
Reacts with
Human
Application
IHC-AFF, ELISA, FC, IHC-FFPE, WB
$720.00
  mAb OASA00562 CCND1 Antibody (OASA00562)
Reacts with
Human
Application
IHC-AFF, ELISA, FC, IP, IHC-FFPE, WB
$490.00
  mAb OASA00738 Ghr Antibody (OASA00738)
Reacts with
Application
IHC-AFF, FC, IP, IHC-FFPE
$530.00
  mAb OASA01129 CSF3R Antibody (OASA01129)
Reacts with
Human
Application
FC
$455.00
  mAb OASA01131 CSF2RA Antibody (OASA01131)
Reacts with
Human
Application
IHC-AFF, FC, IP, WB
$130.00
  mAb OASA01137 IFNGR1 Antibody (OASA01137)
Reacts with
Human
Application
IHC-AFF, ELISA, FC, WB
$495.00
  mAb OASA01186 IL6R Antibody (OASA01186)
Reacts with
Human
Application
IHC-AFF, ELISA, FC, IP
$370.00

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Showing 1 - 30 of 83