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JAK-STAT Pathway

The Janus Kinase (Jak)- Signal Transducer and Activator of Transcription (STAT) signaling pathway converts extracellular signals into intracellular action such as cell migration, proliferation, and differentiation. Jak-STAT signaling is an evolutionarily conserved process that allows a cell to respond to a variety of growth and survival signals. There are three critical components of the Jak-STAT signaling pathway: a cytokine receptor, Jak, and STAT.

During Jak-STAT signaling, Jak will bind to a transmembrane cytokine receptor, which, upon ligand binding, will cause Jak to autophosphorylate. Jak phosphorylation encourages the recruitment of STAT molecules that are, in turn, phosphorylated by Jak. STAT molecules then form hetero- or homodimers and translocate to the nucleus to initiate transcription. There are seven different STAT molecules that interact with unique DNA sequences. Activation of Jaks associated with membrane receptors can also act as docking stations for secondary signaling molecules and adaptors that can link the Jak-STAT pathway to MAPK and other signaling pathways. Suppressors of cytokine signaling (SOCS) that compete with STAT binding sites on receptors and protein inhibitors of activated STAT (PIAS) that inhibit STAT binding to DNA negatively regulate the Jak-STAT pathway.

Jak mutations are hallmarks of many haematological malignancies. For instance, mutations in Jak3 that render it constitutively active can cause acute megakaryoblastic leukemia[1]. Similarly, STAT3, which is phosphorylated during IL-6 signaling, can be oncogenic if not properly controlled; STAT3 dysregulation, therefore, can continually promote an anti-apoptotic cellular milieu[2]. Considering the impact of dysregulated Jak-STAT signaling in a variety of diseases, including inflammatory disorders and malignancies, they are currently the focus of therapeutic intervention.  

1. Walters et al. 2006. Activating alleles of JAK3 in acute megakaryoblastic leukemia. Cancer Cell. 10(1):65-75.
2. Sun et al. 2011. Inhibition of Stat3 activation by sanguinarine suppresses prostate cancer cell growth and invasion. Prostate. [epub ahead of print].

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    Il10ra Antibody (OASA05497)

    Il10ra Antibody (OASA05497)

    Protein Name:Interleukin-10 receptor subunit alpha
    Catalog #:OASA05497
    Type: mAb
    Reacts with: Mouse
    Application: FC
    Product Size: 0.25mg
    Price (USD): $345.00
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    Il13 Antibody (OASA08424)

    Il13 Antibody (OASA08424)

    Protein Name:Interleukin-13
    Catalog #:OASA08424
    Type: pAb
    Reacts with: Mouse
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $555.00
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    Il5 Antibody (OASA05647)

    Il5 Antibody (OASA05647)

    Protein Name:Interleukin-5
    Catalog #:OASA05647
    Type: mAb
    Reacts with: Mouse
    Application: ELISA, WB
    Product Size: 0.5mg
    Price (USD): $510.00
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    CSF2RA Antibody (OASA01131)

    CSF2RA Antibody (OASA01131)

    Protein Name:Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
    Catalog #:OASA01131
    Type: mAb
    Reacts with: Human
    Application: IHC-AFF, FC, IP, WB
    Product Size: 25ug
    Price (USD): $130.00
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    Stat4 Antibody (OASA08477)

    Stat4 Antibody (OASA08477)

    Protein Name:Signal transducer and activator of transcription 4
    Catalog #:OASA08477
    Type: pAb
    Reacts with: Mouse
    Application: ELISA, IP, WB
    Product Size: 50ul
    Price (USD): $380.00
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    EPO Antibody (OASA02761)

    EPO Antibody (OASA02761)

    Protein Name:Erythropoietin
    Catalog #:OASA02761
    Type: mAb
    Reacts with: Human
    Application: ELISA
    Product Size: 0.2mg
    Price (USD): $440.00
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    PRLR Antibody (OASA09262)

    PRLR Antibody (OASA09262)

    Protein Name:Prolactin receptor
    Catalog #:OASA09262
    Type: pAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 1ml
    Price (USD): $255.00
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    GOAT ANTI HUMAN PIK3CG (C-TERMINAL) Antibody

    GOAT ANTI HUMAN PIK3CG (C-TERMINAL) Antibody

    Protein Name:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
    Catalog #:OASA06394
    Type: pAb
    Reacts with:
    Application: WB
    Product Size: 0.1mg
    Price (USD): $460.00
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    SOCS3 Antibody (OASA03292)

    SOCS3 Antibody (OASA03292)

    Protein Name:Suppressor of cytokine signaling 3
    Catalog #:OASA03292
    Type: mAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $300.00
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    Il12b Antibody (OASA06660)

    Il12b Antibody (OASA06660)

    Protein Name:Interleukin-12 subunit beta
    Catalog #:OASA06660
    Type: pAb
    Reacts with: Mouse
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $570.00
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    CNTF Antibody (OASA07632)

    CNTF Antibody (OASA07632)

    Protein Name:Ciliary neurotrophic factor
    Catalog #:OASA07632
    Type: pAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $555.00
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    PIK3R2 Antibody (OASA03637)

    PIK3R2 Antibody (OASA03637)

    Protein Name:Phosphatidylinositol 3-kinase regulatory subunit beta
    Catalog #:OASA03637
    Type: mAb
    Reacts with: Cow
    Application: IHC-AFF, IP, WB
    Product Size: 2ml
    Price (USD): $410.00

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