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JAK-STAT

The Janus Kinase (Jak)- Signal Transducer and Activator of Transcription (STAT) signaling pathway converts extracellular signals into intracellular action such as cell migration, proliferation, and differentiation. Jak-STAT signaling is an evolutionarily conserved process that allows a cell to respond to a variety of growth and survival signals. There are three critical components of the Jak-STAT signaling pathway: a cytokine receptor, Jak, and STAT.

During Jak-STAT signaling, Jak will bind to a transmembrane cytokine receptor, which, upon ligand binding, will cause Jak to autophosphorylate. Jak phosphorylation encourages the recruitment of STAT molecules that are, in turn, phosphorylated by Jak. STAT molecules then form hetero- or homodimers and translocate to the nucleus to initiate transcription. There are seven different STAT molecules that interact with unique DNA sequences. Activation of Jaks associated with membrane receptors can also act as docking stations for secondary signaling molecules and adaptors that can link the Jak-STAT pathway to MAPK and other signaling pathways. Suppressors of cytokine signaling (SOCS) that compete with STAT binding sites on receptors and protein inhibitors of activated STAT (PIAS) that inhibit STAT binding to DNA negatively regulate the Jak-STAT pathway.

Jak mutations are hallmarks of many haematological malignancies. For instance, mutations in Jak3 that render it constitutively active can cause acute megakaryoblastic leukemia[1]. Similarly, STAT3, which is phosphorylated during IL-6 signaling, can be oncogenic if not properly controlled; STAT3 dysregulation, therefore, can continually promote an anti-apoptotic cellular milieu[2]. Considering the impact of dysregulated Jak-STAT signaling in a variety of diseases, including inflammatory disorders and malignancies, they are currently the focus of therapeutic intervention.  

1. Walters et al. 2006. Activating alleles of JAK3 in acute megakaryoblastic leukemia. Cancer Cell. 10(1):65-75.
2. Sun et al. 2011. Inhibition of Stat3 activation by sanguinarine suppresses prostate cancer cell growth and invasion. Prostate. [epub ahead of print].

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    Il2rb Antibody (OASA04861)

    Il2rb Antibody (OASA04861)

    Protein Name:Interleukin-2 receptor subunit beta
    Catalog #:OASA04861
    Type: mAb
    Reacts with: Mouse
    Application: FC, IP
    Product Size: 0.25mg
    Price (USD): $355.00
  •  
    PIK3CD antibody - C-terminal region (OASA08104)

    PIK3CD antibody - C-terminal region (OASA08104)

    Protein Name:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
    Catalog #:OASA08104
    Type: pAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $455.00
  •  
    Csf2 Antibody (OASA05570)

    Csf2 Antibody (OASA05570)

    Protein Name:Granulocyte-macrophage colony-stimulating factor
    Catalog #:OASA05570
    Type: mAb
    Reacts with: Mouse
    Application: ELISA
    Product Size: 0.5mg
    Price (USD): $600.00
  •  
    Gh1 Antibody (OASA08664)

    Gh1 Antibody (OASA08664)

    Protein Name:Somatotropin
    Catalog #:OASA08664
    Type: pAb
    Reacts with: Rat
    Application: IHC-AFF, WB
    Product Size: 50ul
    Price (USD): $515.00
  •  
    GRB2 Antibody (OASA02842)

    GRB2 Antibody (OASA02842)

    Protein Name:Growth factor receptor-bound protein 2
    Catalog #:OASA02842
    Type: mAb
    Reacts with: Human
    Application: WB
    Product Size: 2ml
    Price (USD): $410.00
  •  
    PTPN6 Antibody (OASA06443)

    PTPN6 Antibody (OASA06443)

    Protein Name:Tyrosine-protein phosphatase non-receptor type 6
    Catalog #:OASA06443
    Type: pAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $530.00
  •  
    STAT1 Antibody (OASA03295)

    STAT1 Antibody (OASA03295)

    Protein Name:Signal transducer and activator of transcription 1-alpha/beta
    Catalog #:OASA03295
    Type: mAb
    Reacts with: Human
    Application: IP, WB
    Product Size: 0.1mg
    Price (USD): $310.00
  •  
    GOAT ANTI SOCS-1 Antibody

    GOAT ANTI SOCS-1 Antibody

    Protein Name:Suppressor of cytokine signaling 1
    Catalog #:OASA06852
    Type: pAb
    Reacts with:
    Application: WB
    Product Size: 0.1mg
    Price (USD): $410.00
  •  
    IFNA1 Antibody (OASA03709)

    IFNA1 Antibody (OASA03709)

    Protein Name:Interferon alpha-1
    Catalog #:OASA03709
    Type: mAb
    Reacts with: Pig
    Application: ELISA, WB
    Product Size: 0.25mg
    Price (USD): $720.00
  •  
    CREBBP Antibody (OASA07643)

    CREBBP Antibody (OASA07643)

    Protein Name:CREB-binding protein
    Catalog #:OASA07643
    Type: pAb
    Reacts with: Human
    Application: IP, WB
    Product Size: 0.1mg
    Price (USD): $640.00
  •  
    OSM Antibody (OASA08053)

    OSM Antibody (OASA08053)

    Protein Name:Oncostatin-M
    Catalog #:OASA08053
    Type: pAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $570.00
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    Il2ra Antibody (OASA05092)

    Il2ra Antibody (OASA05092)

    Protein Name:Interleukin-2 receptor subunit alpha
    Catalog #:OASA05092
    Type: mAb
    Reacts with: Mouse
    Application: IHC-AFF, FC, IP
    Product Size: 0.25mg
    Price (USD): $345.00

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