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JAK-STAT

The Janus Kinase (Jak)- Signal Transducer and Activator of Transcription (STAT) signaling pathway converts extracellular signals into intracellular action such as cell migration, proliferation, and differentiation. Jak-STAT signaling is an evolutionarily conserved process that allows a cell to respond to a variety of growth and survival signals. There are three critical components of the Jak-STAT signaling pathway: a cytokine receptor, Jak, and STAT.

During Jak-STAT signaling, Jak will bind to a transmembrane cytokine receptor, which, upon ligand binding, will cause Jak to autophosphorylate. Jak phosphorylation encourages the recruitment of STAT molecules that are, in turn, phosphorylated by Jak. STAT molecules then form hetero- or homodimers and translocate to the nucleus to initiate transcription. There are seven different STAT molecules that interact with unique DNA sequences. Activation of Jaks associated with membrane receptors can also act as docking stations for secondary signaling molecules and adaptors that can link the Jak-STAT pathway to MAPK and other signaling pathways. Suppressors of cytokine signaling (SOCS) that compete with STAT binding sites on receptors and protein inhibitors of activated STAT (PIAS) that inhibit STAT binding to DNA negatively regulate the Jak-STAT pathway.

Jak mutations are hallmarks of many haematological malignancies. For instance, mutations in Jak3 that render it constitutively active can cause acute megakaryoblastic leukemia[1]. Similarly, STAT3, which is phosphorylated during IL-6 signaling, can be oncogenic if not properly controlled; STAT3 dysregulation, therefore, can continually promote an anti-apoptotic cellular milieu[2]. Considering the impact of dysregulated Jak-STAT signaling in a variety of diseases, including inflammatory disorders and malignancies, they are currently the focus of therapeutic intervention.  

1. Walters et al. 2006. Activating alleles of JAK3 in acute megakaryoblastic leukemia. Cancer Cell. 10(1):65-75.
2. Sun et al. 2011. Inhibition of Stat3 activation by sanguinarine suppresses prostate cancer cell growth and invasion. Prostate. [epub ahead of print].

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  •  
    Il12b Antibody (OASA06660)

    Il12b Antibody (OASA06660)

    Protein Name:Interleukin-12 subunit beta
    Catalog #:OASA06660
    Type: pAb
    Reacts with: Mouse
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $570.00
  •  
    SOCS3 Antibody (OASA03292)

    SOCS3 Antibody (OASA03292)

    Protein Name:Suppressor of cytokine signaling 3
    Catalog #:OASA03292
    Type: mAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $300.00
  •  
    CNTF Antibody (OASA07632)

    CNTF Antibody (OASA07632)

    Protein Name:Ciliary neurotrophic factor
    Catalog #:OASA07632
    Type: pAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $555.00
  •  
    Ghr Antibody (OASA00738)

    Ghr Antibody (OASA00738)

    Protein Name:Growth hormone receptor
    Catalog #:OASA00738
    Type: mAb
    Reacts with:
    Application: IHC-AFF, FC, IP, IHC-FFPE
    Product Size: 0.2mg
    Price (USD): $530.00
  •  
    Lep Antibody (OASA08447)

    Lep Antibody (OASA08447)

    Protein Name:Leptin
    Catalog #:OASA08447
    Type: pAb
    Reacts with: Mouse
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $570.00
  •  
    LEPR Antibody (OASA06331)

    LEPR Antibody (OASA06331)

    Protein Name:Leptin receptor
    Catalog #:OASA06331
    Type: pAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $515.00
  •  
    IL6ST Antibody (OASA01196)

    IL6ST Antibody (OASA01196)

    Protein Name:Interleukin-6 receptor subunit beta
    Catalog #:OASA01196
    Type: mAb
    Reacts with: Human
    Application: ELISA, FC
    Product Size: 0.1mg
    Price (USD): $485.00
  •  
    STAT6 Antibody (OASA08812)

    STAT6 Antibody (OASA08812)

    Protein Name:Signal transducer and activator of transcription 6
    Catalog #:OASA08812
    Type: pAb
    Reacts with: Human
    Application: IP, WB
    Product Size: 50ug
    Price (USD): $410.00
  •  
    SOCS2 Antibody (OASA06451)

    SOCS2 Antibody (OASA06451)

    Protein Name:Suppressor of cytokine signaling 2
    Catalog #:OASA06451
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 0.1mg
    Price (USD): $560.00
  •  
    IL4R Antibody (OASA03006)

    IL4R Antibody (OASA03006)

    Protein Name:Interleukin-4 receptor subunit alpha
    Catalog #:OASA03006
    Type: mAb
    Reacts with: Human
    Application: ELISA, FC, IHC-FFPE, WB
    Product Size: 0.1mg
    Price (USD): $600.00
  •  
    AKT1 antibody - N-terminal region (OASA06961)

    AKT1 antibody - N-terminal region (OASA06961)

    Protein Name:RAC-alpha serine/threonine-protein kinase
    Catalog #:OASA06961
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 0.1mg
    Price (USD): $310.00
  •  
    PIK3R3 Antibody (OASA03634)

    PIK3R3 Antibody (OASA03634)

    Protein Name:Phosphatidylinositol 3-kinase regulatory subunit gamma
    Catalog #:OASA03634
    Type: mAb
    Reacts with: Cow
    Application: IP, WB
    Product Size: 2ml
    Price (USD): $410.00

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