CCL2 Antibody - middle region (AVARP07046_P050)

Catalog No: AVARP07046_P050

WB Suggested Anti-CCL2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Transfected 293T

Sample Type: Kidney

Sample Type: Human Macrophange Cells
Green: primary
Red: phallodin
Blue: DAPI
Yellow: green/red
Primary Dilution: 1:200
Secondary Antibody: anti-Rabbit IgG-FITC
Secondary Dilution: 1:1000
Image Submitted By: Milan Fiala
University of California, Los Angeles 

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Dog
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: IHC, WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CCL2
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Dog: 75%; Human: 100%
• Peptide Sequence: Synthetic peptide located within the following region: ASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPK
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-CCL2 (AVARP07046_P050) antibody is Catalog # AAP30817 (Previous Catalog # AAPP01481)
• Reference: Carulli,M.T., (2008) J. Rheumatol. 35 (5), 839-844
  Pottekat, A. et al. (2013). Cell Reports 4, 921-930.
• Publications:

  Key Players of Cisplatin Resistance: Towards a Systems Pharmacology Approach. Int J Mol Sci. 19, (2018). 29518977

• Description:
  View product citations for CCL2 Antibody - middle region (AVARP07046_P050) on CiteAb

Target Info

• Gene Symbol: CCL2
• Gene Full Name: Chemokine (C-C motif) ligand 2
• Alias Symbols: HC11, MCAF, MCP1, MCP-1, SCYA2, GDCF-2, SMC-CF, HSMCR30
• NCBI Gene Id: 6347
• Protein Name: C-C motif chemokine 2
• Description of Target: CCL2 is a chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. CCL2 augments monocyte anti-tumor activity. CCL2 has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. CCL2 may be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
• Uniprot ID: P13500
• Protein Accession #: NP_002973
• Nucleotide Accession #: NM_002982
• Protein Size (# AA): 99
• Molecular Weight: 11kDa
• Protein Interactions: Ccr2; CDC45; PCNA; ORC4; ORC2; MCM7; MCM3; MCM2; CDC6; ACKR2; ACKR4; CCR5; CCR1; CCR10; MMP3; CCL2; MMP8; MMP1; VCAN; ACKR1; CCL5; CCR3;