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Epigenetics

Epigenetics is the study of gene expression changes that result from processes that do not involve alteration of the DNA sequence. During embryogenesis, various epigenetic mechanisms play important roles in governing proper development, including chromatin remodeling and DNA methylation. Given that primary DNA sequences are not altered in a developing embryo, it is the epigenetic modifications that underlie the spatial and temporal control of gene expression. Hyper- and hypo-methylation of DNA can result in reduced and increased transcription of specific genes, respectively. Aberrant methylation patterns have been linked to the development and progression of a variety of cancers. Genomic imprinting is another epigenetic process that has been associated with human diseases, including Angelman Syndrome. Other epigenetic processes include histone acetylation and deacetylation, X chromosome inactivation, and heterochromatin regulation. While it is known that epigenetic changes can be maintained during cell division, evidence is mounting to support the notion that epigenetic marks can be transmitted from one generation to the next. Environmental factors such as stress and diet can have epigenetic consequences and these consequences may be passed on to offspring[1].

1. Waterland RA and Jirtle RL. 2003. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol. Aug;23(15):5293-300.

Epigenetics is study of inherited changes in phenotype (appearance) or gene expression caused by mechanisms other than changes in the underlying DNA sequence. We have manufactured about 400 products for proteins related to Epigenetic research.

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Showing 721 - 738 of 738
  Type Catalog # Product Product Images Price (USD)
  pAb OAAB03896 ALKBH8 antibody - C-terminal region (OAAB03896)
Reacts with
Human
Application
WB, IHC, FC, ELISA
$289.00
  pAb ARP51333_P050 CDC45L antibody - C-terminal region (ARP51333_P050)
Reacts with
Bovine, Rat, Dog, Mouse, Guinea pig, Horse, Human, Rabbit
Application
WB
$289.00
  pAb ARP34171_P050 SMARCB1 antibody - N-terminal region (ARP34171_P050)
Reacts with
Human, Dog, Pig, Horse, Rat, Guinea pig, Bovine, Mouse
Application
IHC, WB
$289.00
  pAb ARP45826_P050 CHAF1B antibody - N-terminal region (ARP45826_P050)
Reacts with
Human, Mouse, Dog, Pig, Horse, Rabbit, Rat, Bovine, Zebrafish, Guinea pig
Application
WB
$289.00
  pAb ARP34721_T100 CBX3 antibody - middle region (ARP34721_T100)
Reacts with
Human, Bovine, Mouse, Rat, Dog, Pig, Horse, Rabbit, Guinea pig
Application
IHC, WB
$229.00
  pAb ARP32479_P050 NCOR1 antibody - N-terminal region (ARP32479_P050)
Reacts with
Dog, Human, Mouse, Bovine, Rat, Pig, Horse, Guinea pig, Yeast
Application
IHC, WB
$289.00
  pAb ARP44327_P050 COMT antibody - middle region (ARP44327_P050)
Reacts with
Bovine, Human, Pig, Horse, Rat, Mouse, Guinea pig, Rabbit, Dog
Application
WB
$289.00
  pAb OAAB02229 WDR82 antibody - N-terminal region (OAAB02229)
Reacts with
Human
Application
WB, FC, IHC, ELISA
$289.00
  pAb OAAB04851 CYP3A5 antibody - center region (OAAB04851)
Reacts with
Human
Application
WB, IHC, FC, ELISA
$289.00
  pAb OAAB05122 IL1B antibody - center region (OAAB05122)
Reacts with
Human
Application
WB, IHC, FC, ELISA
$289.00
  pAb OAAB01375 PHB antibody - center region (OAAB01375)
Reacts with
Human
Application
WB, IHC, ELISA
$289.00
  pAb ARP37145_P050 SREBF1 antibody - N-terminal region (ARP37145_P050)
Reacts with
Mouse, Rat
Application
WB
$289.00
  pAb OAAB05767 APOBEC3F antibody - N-terminal region (OAAB05767)
Reacts with
Human
Application
WB, FC, IHC, ELISA
$289.00
  pAb ARP38681_T100 TRIM28 antibody - C-terminal region (ARP38681_T100)
Reacts with
Human, Bovine, Dog, Horse, Rabbit, Rat, Guinea pig, Mouse
Application
IHC, WB
$229.00
  pAb ARP38530_T100 HDAC1 antibody - C-terminal region (ARP38530_T100)
Reacts with
Human, Mouse, Rat, Dog, Pig, Guinea pig, Bovine, Horse, Yeast, Rabbit, Zebrafish
Application
WB
$229.00
  pAb OAAB03860 GATA2 antibody - C-terminal region (OAAB03860)
Reacts with
Human
Application
WB, FC, ELISA
$289.00
  pAb ARP64152_P050 WISP2 antibody - C-terminal region (ARP64152_P050)
Reacts with
Human, Dog, Pig, Horse, Rat
Application
WB
$289.00
  pAb ARP46350_P050 CDT1 antibody - C-terminal region (ARP46350_P050)
Reacts with
Human, Rat, Pig, Mouse, Bovine, Rabbit, Yeast, Dog
Application
IHC, WB
$289.00

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Showing 721 - 738 of 738