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Catalog No: P100799_P050
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P100799_P050
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Datasheets/ManualsPrintable datasheet for anti-SSRP1 (P100799_P050) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Mouse, Rat, Cow
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the middle region of human SSRP1
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 100%; Human: 100%; Mouse: 100%; Rat: 100%
Peptide SequenceSynthetic peptide located within the following region: MKEYEGGRGESSKRDKSKKKKKVKVKMEKKSTPSRGSSSKSSSRQLSESF
Concentration0.5 mg/ml
Blocking PeptideFor anti-SSRP1 (P100799_P050) antibody is Catalog # AAP31140 (Previous Catalog # AAPP01879)
SubunitSSRP1
ReferenceLi,Y., (2007) J. Biol. Chem. 282 (10), 6936-6945
Description
Gene SymbolSSRP1
Gene Full NameStructure specific recognition protein 1
Alias SymbolsFACT, T160, FACT80
NCBI Gene Id6749
Protein NameFACT complex subunit SSRP1
Description of TargetSSRP1 is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. SSRP1 contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. It also functions as a co-activator of the transcriptional activator p63. The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Uniprot IDQ08945
Protein Accession #NP_003137
Nucleotide Accession #NM_003146
Protein Size (# AA)709
Molecular Weight81kDa
Protein InteractionsSUMO2; SUMO3; ATRX; UBC; EED; RNF2; SEC24C; CUL1; CSDE1; ATP6V1B2; DIABLO; SBNO1; PBDC1; EXOSC10; CSNK2A1; PNKP; VCAM1; SRPK1; ITGA4; FMNL1; SUPT16H; CENPA; LEO1; PAF1; PHGDH; SF3B1; NCSTN; RTF1; RBM14; SAP18; CTR9; S100A9; NOP2; HMGB1; HIST1H2BB; DHX9; C
  1. What is the species homology for "SSRP1 Antibody - middle region (P100799_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow".

  2. How long will it take to receive "SSRP1 Antibody - middle region (P100799_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "SSRP1 Antibody - middle region (P100799_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "SSRP1 Antibody - middle region (P100799_P050)"?

    This target may also be called "FACT, T160, FACT80" in publications.

  5. What is the shipping cost for "SSRP1 Antibody - middle region (P100799_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "SSRP1 Antibody - middle region (P100799_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "SSRP1 Antibody - middle region (P100799_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "81kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "SSRP1 Antibody - middle region (P100799_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "SSRP1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "SSRP1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "SSRP1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "SSRP1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "SSRP1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "SSRP1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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