Catalog No: ARP40731_P050
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ARP40731_P050
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Datasheets/ManualsPrintable datasheet for anti-SF3B3 (ARP40731_P050) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the middle region of human SF3B3
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 79%
Peptide SequenceSynthetic peptide located within the following region: EHPPLCGRDHLSFRSYYFPVKNVIDGDLCEQFNSMEPNKQKNVSEELDRT
Concentration0.5 mg/ml
Blocking PeptideFor anti-SF3B3 (ARP40731_P050) antibody is Catalog # AAP40731 (Previous Catalog # AAPY00983)
Subunit3
ReferenceEwing,R.M., Mol. Syst. Biol. 3, 89 (2007)
Gene SymbolSF3B3
Gene Full NameSplicing factor 3b, subunit 3, 130kDa
Alias SymbolsRSE1, SAP130, SF3b130, STAF130
NCBI Gene Id23450
Protein NameSplicing factor 3B subunit 3
Description of TargetSF3B3 is subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Uniprot IDQ15393
Protein Accession #NP_036558
Nucleotide Accession #NM_012426
Protein Size (# AA)1217
Molecular Weight135kDa
Protein InteractionsHUWE1; UBC; FUS; SUMO2; NUDCD3; LGR4; SUMO1; NEDD8; MDM2; RPA3; RPA2; RPA1; ERG; SUZ12; EED; RNF2; EZH2; PRPF40A; WWOX; APBB1; WBP4; TCERG1; FBXO6; CUL1; CUL2; CUL3; CUL4A; SKP2; SKP1; CD81; IGSF8; RBM6; EFTUD2; WHSC1; IFIT3; HSP90AA1; HSPB1; EPS8; TOE1;
  1. What is the species homology for "SF3B3 Antibody - middle region (ARP40731_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish".

  2. How long will it take to receive "SF3B3 Antibody - middle region (ARP40731_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "SF3B3 Antibody - middle region (ARP40731_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "SF3B3 Antibody - middle region (ARP40731_P050)"?

    This target may also be called "RSE1, SAP130, SF3b130, STAF130" in publications.

  5. What is the shipping cost for "SF3B3 Antibody - middle region (ARP40731_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "SF3B3 Antibody - middle region (ARP40731_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "SF3B3 Antibody - middle region (ARP40731_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "135kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "SF3B3 Antibody - middle region (ARP40731_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "SF3B3"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "SF3B3"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "SF3B3"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "SF3B3"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "SF3B3"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "SF3B3"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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