MYOM1 Antibody - C-terminal region (ARP65177_P050)

Catalog No: ARP65177_P050

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Host: Rabbit
Target Name: MYOM1
Antibody Dilution: 1.0ug/ml
Sample Type: NCI-H226 cell lysateMYOM1 is supported by BioGPS gene expression data to be expressed in NCIH226

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 93%; Dog: 86%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 86%; Rat: 100%; Zebrafish: 79%
• Peptide Sequence: Synthetic peptide located within the following region: FEAGRTAYFTINGVSTADSGKYGLVVKNKYGSETSDFTVSVFIPEEEARM
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-MYOM1 (ARP65177_P050) antibody is Catalog # AAP65177
• Sample Type Confirmation:

  MYOM1 is supported by BioGPS gene expression data to be expressed in NCIH226

Target Info

• Gene Symbol: MYOM1
• Gene Full Name: Myomesin 1, 185kDa
• Alias Symbols: SKELEMIN
• NCBI Gene Id: 8736
• Protein Name: Myomesin-1
• Description of Target: The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD (myomesin 1) and 165 kD (myomesin 2). This protein, myomesin 1, like myomesin 2, titin, and other myofibrillar proteins contains structural modules with strong homology to either fibronectin type III (motif I) or immunoglobulin C2 (motif II) domains. Myomesin 1 and myomesin 2 each have a unique N-terminal region followed by 12 modules of motif I or motif II, in the arrangement II-II-I-I-I-I-I-II-II-II-II-II. The two proteins share 50% sequence identity in this repeat-containing region. The head structure formed by these 2 proteins on one end of the titin string extends into the center of the M band. The integrating structure of the sarcomere arises from muscle-specific members of the superfamily of immunoglobulin-like proteins. Alternatively spliced transcript variants encoding different isoforms have been identified.
• Uniprot ID: P52179
• Protein Accession #: NP_062830
• Nucleotide Accession #: NM_019856
• Protein Size (# AA): 1589
• Molecular Weight: 178kDa
• Protein Interactions: TTN; MYH9; MYOM1;