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Epigenetics

Epigenetics is the study of gene expression changes that result from processes that do not involve alteration of the DNA sequence. During embryogenesis, various epigenetic mechanisms play important roles in governing proper development, including chromatin remodeling and DNA methylation. Given that primary DNA sequences are not altered in a developing embryo, it is the epigenetic modifications that underlie the spatial and temporal control of gene expression. Hyper- and hypo-methylation of DNA can result in reduced and increased transcription of specific genes, respectively. Aberrant methylation patterns have been linked to the development and progression of a variety of cancers. Genomic imprinting is another epigenetic process that has been associated with human diseases, including Angelman Syndrome. Other epigenetic processes include histone acetylation and deacetylation, X chromosome inactivation, and heterochromatin regulation. While it is known that epigenetic changes can be maintained during cell division, evidence is mounting to support the notion that epigenetic marks can be transmitted from one generation to the next. Environmental factors such as stress and diet can have epigenetic consequences and these consequences may be passed on to offspring[1].

1. Waterland RA and Jirtle RL. 2003. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol. Aug;23(15):5293-300.

Epigenetics is study of inherited changes in phenotype (appearance) or gene expression caused by mechanisms other than changes in the underlying DNA sequence. We have manufactured about 400 products for proteins related to Epigenetic research.

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  Type Catalog # Product Product Images Price (USD)
  pAb ARP72851_P050 KDM5B Antibody - C-terminal region (ARP72851_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP68663_P050 KANSL2 Antibody - N-terminal region (ARP68663_P050)
Reacts with
Pig, Human, Rabbit, Dog, Horse, Rat, Guinea pig, Goat, Zebrafish, Mouse, Bovine
Application
WB
$289.00
  pAb ARP33022_P050 KDM3B Antibody - N-terminal region (ARP33022_P050)
Reacts with
Human, Bovine, Dog, Pig, Horse, Rabbit, Rat, Guinea pig, Mouse
Application
WB
$289.00
  pAb ARP35489_P050 KCNIP2 antibody - C-terminal region (ARP35489_P050)
Reacts with
Pig, Human, Bovine, Rat, Mouse, Dog, Horse, Rabbit, Guinea pig
Application
WB
$289.00
  pAb ARP70622_P050 KDM4E Antibody - N-terminal region (ARP70622_P050)
Reacts with
Human, Rat, Mouse, Bovine, Dog, Horse, Guinea pig, Zebrafish, Rabbit
Application
WB
$289.00
  pAb ARP66383_P050 KDM1B Antibody - N-terminal region (ARP66383_P050)
Reacts with
Mouse, Rat, Bovine, Dog, Pig, Human, Horse, Rabbit, Guinea pig
Application
WB
$289.00
  pAb OAAB01112 KDM3A antibody - N-terminal region (OAAB01112)
Reacts with
Human; Mouse
Application
WB, IHC
$289.00
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