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Datasheets/Manuals | Printable datasheet for anti-TRAF6 (ARP30357_T100) antibody |
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Tested Species Reactivity | Human, Mouse |
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Predicted Species Reactivity | Human, Mouse, Rat, Cow, Horse, Pig, Rabbit |
Product Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Clonality | Polyclonal |
Host | Rabbit |
Application | WB |
Reconstitution and Storage | For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Immunogen | The immunogen is a synthetic peptide directed towards the C-terminal region of Human TRAF6 |
Predicted Homology Based on Immunogen Sequence | Cow: 100%; Horse: 100%; Human: 100%; Mouse: 91%; Pig: 100%; Rabbit: 100%; Rat: 100% |
Peptide Sequence | Synthetic peptide located within the following region: FGYVTFMHLEALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDA |
Concentration | 1.0 mg/ml |
Blocking Peptide | For anti-TRAF6 (ARP30357_T100) antibody is Catalog # AAP30357 |
Gene Symbol | TRAF6 |
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Alias Symbols | RNF85, MGC:3310 |
NCBI Gene Id | 7189 |
Description of Target | TRAF6 is an E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. It also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. It may be essential for the formation of functional osteoclasts. It seems to also play a role in dendritic cells (DCs) maturation and/or activation. It represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. It regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. |
Uniprot ID | Q9Y4K3 |
Protein Accession # | NP_004611 |
Nucleotide Accession # | NM_004620 |
Protein Size (# AA) | 522 |
Molecular Weight | 57kDa |
Protein Interactions | YES1; UBE2V1; UBE2N; UBE2L3; UBE2E1; UBE2D2; UBE2D1; POLI; UBC; IL1R1; EDARADD; PLEKHF2; LAT; TRAF3IP2; PPP4R1; USP2; IKBKG; TRAF6; TRAF5; TRAF2; TRAF1; CNTN2; SYK; VPS52; PSEN1; LGMN; MEOX2; MCL1; CANX; nef; TAB2; OTUD7A; GTF2I; KRAS; DCBLD2; MAP3K7; EIF |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "TRAF6 Antibody - C-terminal region (ARP30357_T100)"?
The tested species reactivity for this item is "Human, Mouse". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Horse, Pig, Rabbit".
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How long will it take to receive "TRAF6 Antibody - C-terminal region (ARP30357_T100)"?
This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".
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What buffer format is "TRAF6 Antibody - C-terminal region (ARP30357_T100)" provided in?
This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "TRAF6 Antibody - C-terminal region (ARP30357_T100)"?
This target may also be called "RNF85, MGC:3310" in publications.
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What is the shipping cost for "TRAF6 Antibody - C-terminal region (ARP30357_T100)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "TRAF6 Antibody - C-terminal region (ARP30357_T100)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "TRAF6 Antibody - C-terminal region (ARP30357_T100)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "57kDa".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "TRAF6 Antibody - C-terminal region (ARP30357_T100)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "TRAF6"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "TRAF6"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "TRAF6"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "TRAF6"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "TRAF6"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "TRAF6"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.