Catalog No: AVARP09044_P050
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AVARP09044_P050
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Datasheets/ManualsPrintable datasheet for anti-NFKBIA (AVARP09044_P050) antibody
Product Info
Tested Species ReactivityHuman, Mouse
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Dog, Horse, Pig, Sheep
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the middle region of human NFKBIA
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 100%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%; Sheep: 100%
Peptide SequenceSynthetic peptide located within the following region: SPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTEFTED
Concentration0.5 mg/ml
Blocking PeptideFor anti-NFKBIA (AVARP09044_P050) antibody is Catalog # AAP30582 (Previous Catalog # AAPP01234)
ReferenceTruhlar,S.M., (2008) J. Mol. Biol. 380 (1), 67-82
Gene SymbolNFKBIA
Gene Full NameNuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Alias SymbolsIKBA, MAD-3, NFKBI, EDAID2
NCBI Gene Id4792
Protein NameNF-kappa-B inhibitor alpha
Description of TargetNFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Uniprot IDP25963
Protein Accession #NP_065390
Nucleotide Accession #NM_020529
Protein Size (# AA)317
Molecular Weight35kDa
Protein InteractionsBTRC; NEDD9; IKBKB; CHUK; UBC; MTOR; IKBKG; SKP1; FBXW11; UBE2D3; RELA; NPLOC4; VCP; UFD1L; NFKB1; TNF; SUMO1; UBE2D1; COPS3; GPS1; SUMO3; Csnk2b; PRKCA; ST7; STAT1; REL; POLR2C; CD7; ARRB2; ARRB1; SUMO2; PSMA1; ZNF212; IKZF4; ATF4; TBK1; IKBKE; DNAJA3; S
  1. What is the species homology for "NFKBIA Antibody - middle region (AVARP09044_P050)"?

    The tested species reactivity for this item is "Human, Mouse". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Horse, Pig, Sheep".

  2. How long will it take to receive "NFKBIA Antibody - middle region (AVARP09044_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "NFKBIA Antibody - middle region (AVARP09044_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "NFKBIA Antibody - middle region (AVARP09044_P050)"?

    This target may also be called "IKBA, MAD-3, NFKBI, EDAID2" in publications.

  5. What is the shipping cost for "NFKBIA Antibody - middle region (AVARP09044_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "NFKBIA Antibody - middle region (AVARP09044_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "NFKBIA Antibody - middle region (AVARP09044_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "35kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "NFKBIA Antibody - middle region (AVARP09044_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "NFKBIA"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "NFKBIA"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "NFKBIA"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "NFKBIA"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "NFKBIA"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "NFKBIA"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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