website statistics
Account Login 

Now Offering Over 85,203 Antibodies & 34,301 Antigens!

Print Page
50ug
$289.00
In Stock

NFKBIB antibody - middle region (ARP34381_P050)

Description of Target:
Inhibition of NFkappa-B activity by the hepatitis C virus core protein might be related to its physical interaction with and interrupted nuclear localization of IKKbeta. Increased nuclear factor-kappaB (NF-kB) activity in the amnion during labor is associated with an increase in the expression of NF-kBp65 and of the NF-kB binding proteins IkBa, IkBb-1 and IkBb-2. IkappaBbeta may be a novel target for transcription factors of the HMG-box SRY/Sox family and imply a potential role for NF-kappaB/IkappaBbeta in spermatogenesis. NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-766 BM449613.1 1-766 767-1189 BU634404.1 18-440 c 1190-1198 AI684894.1 1-9 c
Gene Symbol:
NFKBIB
Official Gene Full Name:
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NCBI Gene Id:
4793
Alias Symbols:
IKBB; TRIP9
Sample Type Confirmation:

NFKBIB is strongly supported by BioGPS gene expression data to be expressed in 721_B

Tissue Tool:
Find tissues and cell lines supported to express NFKBIB.
Protein Accession #:
NP_002494
Nucleotide Accession#:
NM_002503
Swissprot Id:
Q15653
Host:
Rabbit
Clonality:
Polyclonal
Protein Name:
NF-kappa-B inhibitor beta
Protein Size (# AA):
356
Molecular Weight:
38kDa
Application:
WB
Partner Proteins:
IKBKB, MCC, RELA, RELA, BTRC, CD3EAP, CHUK, CUL1, IKBKB, IKBKG, KPNA2, LRPPRC, MCC, MTIF2, NFKB1, NFKB2, NFKBIA, NGFR, NKIRAS1, NKIRAS2, PDCD2, POLR1A, POLR1B, POLR1C, POLR1D, POLR1E, POLR2H, POLR2L, RASAL2, REL, RELA, RXRA, SKP1, BTRC, CHUK, IKBKB, NKIRAS1, REL, RELA, RXRA, Thrb
Immunogen:
The immunogen for anti-NFKBIB antibody: synthetic peptide directed towards the middle region of human NFKBIB
Product Format:
Lyophilized powder
Purification:
Affinity Purified
Complete computational species homology data:
NFKBIB antibody - middle region (ARP34381_P050)
Predicted Homology Based on Immunogen Sequence:
Dog: 100%; Pig: 100%; Rat: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Bovine: 93%; Guinea pig: 93%; Rabbit: 91%
Species Reactivity:
Dog, Horse, Pig, Human, Rat, Mouse, Bovine, Guinea pig, Rabbit
Datasheets / Downloads:
Printable datasheet for
anti-NFKBIB antibody
- ARP34381_P050
Peptide Sequence:
Synthetic peptide located within the following region: PILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEGDEYDDIVVHSSRS
Blocking Peptide:
For anti-NFKBIB antibody is Catalog # AAP34381 (Previous Catalog # AAPY00223)
Target Reference:
Kerppola,T.K. (er) Ann. Rheum. Dis. (2008) In press
Reconstitution and Storage:
Add 50 ul of distilled water. Final anti-NFKBIB antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.

Computational species homology for NFKBIB antibody (ARP34381)

Product page for NFKBIB antibody (ARP34381)

The information below lists the predicted species and target name associated to the peptide antigen. Please note, all available target reference numbers to the antigen sequence are presented, including unreviewed and protein isoforms.
To search for antibodies by species, please visit Aviva’s Species Reactivity Page. To search Aviva’s catalog of antibodies by sequence, please visit Aviva’s Antibody Blast Tool.

Predicted Species & Target Target Reference Predicted Homology
African elephant NFKBIB antibody; Loxodonta africana NFKBIB antibody G3TL44 92%
Bovine BT.20178 antibody; Bos taurus BT.20178 antibody F1N2I4 92%
Bovine NFKBIB antibody; Bos taurus NFKBIB antibody Q0IIB2 92%
Bovine TSR1 antibody; Bos taurus TSR1 antibody F1MSR6 83%
Bovine TSR1 antibody; Bos taurus TSR1 antibody A6QQN4 83%
Dog NFKBIB antibody; Canis familiaris NFKBIB antibody E2QUS5 100%
Giant panda NFKBIB antibody; Ailuropoda melanoleuca NFKBIB antibody G1LQB0 100%
Giant panda NFKBIB antibody; Ailuropoda melanoleuca NFKBIB antibody G1LQA7 100%
Gray short-tailed opossum LOC100013691 antibody; Monodelphis domestica LOC100013691 antibody F7C514 85%
Guinea pig LOC100734800 antibody; Cavia porcellus LOC100734800 antibody H0VN57 92%
Horse NFKBIB antibody; Equus caballus NFKBIB antibody F7DFW6 100%
Horse TSR1 antibody; Equus caballus TSR1 antibody F6YAX8 90%
Human IKBB antibody; Homo sapiens IKBB antibody Q15653 100%
Little brown bat NFKBIB antibody; Myotis lucifugus NFKBIB antibody G1NUK2 100%
Lowland gorilla NFKBIB antibody; Gorilla gorilla gorilla NFKBIB antibody G3QJ70 100%
Mouse IKBB antibody; Mus musculus IKBB antibody Q60778 100%
Mouse Nfkbib antibody; Mus musculus Nfkbib antibody Q8VC27 100%
Mouse Nfkbib antibody; Mus musculus Nfkbib antibody Q80WN1 100%
Pig TSR1 antibody; Sus scrofa TSR1 antibody F1RHG8 83%
Rabbit LOC100359283 antibody; Oryctolagus cuniculus LOC100359283 antibody G1TL53 85%
Rabbit TSR1 antibody; Oryctolagus cuniculus TSR1 antibody G1TXB8 90%
Rabbit TSR1 antibody; Oryctolagus cuniculus TSR1 antibody G1T719 90%
Rat IKBB antibody; Rattus norvegicus IKBB antibody Q9JIA3 100%
Rat Nfkbib antibody; Rattus norvegicus Nfkbib antibody Q5U342 100%
Rhesus macaque NFKBIB antibody; Macaca mulatta NFKBIB antibody F7H1N6 100%
Small-eared galago NFKBIB antibody; Otolemur garnettii NFKBIB antibody H0WY54 92%
White-tufted-ear marmoset LOC100408512 antibody; Callithrix jacchus LOC100408512 antibody F6X3L6 100%

Product Protocols: NFKBIB antibody tested with Human 721_B_Lymphoblast (ARP34381_P050)

Aviva Systems Biology is the original manufacturer of this NFKBIB antibody (ARP34381_P050)

Click here to view the NFKBIB antibody Western Blot Protocol

Product Datasheet Link: NFKBIB antibody (ARP34381_P050)

WB Suggested Anti-NFKBIB Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: 721_B

Western Blot image:


Description of Target: Inhibition of NFkappa-B activity by the hepatitis C virus core protein might be related to its physical interaction with and interrupted nuclear localization of IKKbeta. Increased nuclear factor-kappaB (NF-kB) activity in the amnion during labor is associated with an increase in the expression of NF-kBp65 and of the NF-kB binding proteins IkBa, IkBb-1 and IkBb-2. IkappaBbeta may be a novel target for transcription factors of the HMG-box SRY/Sox family and imply a potential role for NF-kappaB/IkappaBbeta in spermatogenesis. NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-766 BM449613.1 1-766 767-1189 BU634404.1 18-440 c 1190-1198 AI684894.1 1-9 c

Questions pertaining to this data can be directed to techsupport@avivasysbio.com

Aviva Systems Biology’s NFKBIB antibody (ARP34381_P050) has been tested using other cell lysates and tissues. To obtain more data about this antibody please email us at info@avivasysbio.com.

To order by phone call us at (888) 880-0001, fax us at (858) 552-6975 or send an email to info@avivasysbio.com. Aviva manufactures this antibody so we can offer the best price. Please contact us to request pricing information.

All of Aviva’s products are guaranteed for the applications and experimental sample types mentioned in the datasheet below. Are you curious if this product will work for you? Please contact us at techsupport@avivasysbio.com

 
X
Ask a Question