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Now Offering Over 85,203 Antibodies & 34,301 Antigens!

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NFKBIB antibody - middle region (ARP34381_P050)

Description of Target:
Inhibition of NFkappa-B activity by the hepatitis C virus core protein might be related to its physical interaction with and interrupted nuclear localization of IKKbeta. Increased nuclear factor-kappaB (NF-kB) activity in the amnion during labor is associated with an increase in the expression of NF-kBp65 and of the NF-kB binding proteins IkBa, IkBb-1 and IkBb-2. IkappaBbeta may be a novel target for transcription factors of the HMG-box SRY/Sox family and imply a potential role for NF-kappaB/IkappaBbeta in spermatogenesis. NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-766 BM449613.1 1-766 767-1189 BU634404.1 18-440 c 1190-1198 AI684894.1 1-9 c
Gene Symbol:
NFKBIB
Official Gene Full Name:
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NCBI Gene Id:
4793
Alias Symbols:
IKBB; TRIP9
Sample Type Confirmation:

NFKBIB is strongly supported by BioGPS gene expression data to be expressed in 721_B

Tissue Tool:
Find tissues and cell lines supported to express NFKBIB.
Protein Accession #:
NP_002494
Nucleotide Accession#:
NM_002503
Swissprot Id:
Q15653
Host:
Rabbit
Clonality:
Polyclonal
Protein Name:
NF-kappa-B inhibitor beta
Protein Size (# AA):
356
Molecular Weight:
38kDa
Application:
WB
Partner Proteins:
IKBKB, MCC, RELA, RELA, BTRC, CD3EAP, CHUK, CUL1, IKBKB, IKBKG, KPNA2, LRPPRC, MCC, MTIF2, NFKB1, NFKB2, NFKBIA, NGFR, NKIRAS1, NKIRAS2, PDCD2, POLR1A, POLR1B, POLR1C, POLR1D, POLR1E, POLR2H, POLR2L, RASAL2, REL, RELA, RXRA, SKP1, BTRC, CHUK, IKBKB, NKIRAS1, REL, RELA, RXRA, Thrb
Immunogen:
The immunogen for anti-NFKBIB antibody: synthetic peptide directed towards the middle region of human NFKBIB
Product Format:
Lyophilized powder
Purification:
Affinity Purified
Complete computational species homology data:
NFKBIB antibody - middle region (ARP34381_P050)
Predicted Homology Based on Immunogen Sequence:
Dog: 100%; Pig: 100%; Rat: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Bovine: 93%; Guinea pig: 93%; Rabbit: 91%
Species Reactivity:
Dog, Horse, Pig, Human, Rat, Mouse, Bovine, Guinea pig, Rabbit
Datasheets / Downloads:
Printable datasheet for
anti-NFKBIB antibody
- ARP34381_P050
Peptide Sequence:
Synthetic peptide located within the following region: PILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEGDEYDDIVVHSSRS
Blocking Peptide:
For anti-NFKBIB antibody is Catalog # AAP34381 (Previous Catalog # AAPY00223)
Key Reference:
Kerppola,T.K. (er) Ann. Rheum. Dis. (2008) In press
Reconstitution and Storage:
Add 50 ul of distilled water. Final anti-NFKBIB antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
 
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