MCM5 Antibody - N-terminal region (ARP36654_T100)

Catalog No: ARP36654_T100

WB Suggested Anti-MCM5 Antibody Titration: 2.5ug/ml
ELISA Titer: 1:62500
Positive Control: HepG2 cell lysate

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Horse, Rabbit
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MCM5
• Purification: Protein A purified
• Predicted Homology Based on Immunogen Sequence: Cow: 86%; Horse: 86%; Human: 100%; Mouse: 79%; Rabbit: 86%; Rat: 79%
• Peptide Sequence: Synthetic peptide located within the following region: MSGFDDPGIFYSDSFGGDAQADEGQARKSQLQRRFKEFLRQYRVGTDRTG
• Concentration: 1.0 mg/ml
• Blocking Peptide: For anti-MCM5 (ARP36654_T100) antibody is Catalog # AAP36654 (Previous Catalog # AAPP07911)
• Reference: Ohtani,K., et al., (1999) Oncogene 18 (14), 2299-2309

Target Info

• Gene Symbol: MCM5
• Gene Full Name: Minichromosome maintenance complex component 5
• Alias Symbols: CDC46, MGORS8, P1-CDC46
• NCBI Gene Id: 4174
• Protein Name: DNA replication licensing factor MCM5
• Description of Target: The protein encoded by MCM5 is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation.
• Uniprot ID: P33992
• Protein Accession #: NP_006730
• Nucleotide Accession #: NM_006739
• Protein Size (# AA): 734
• Molecular Weight: 82kDa
• Protein Interactions: KRTAP10-7; RBPMS; SUMO2; SUMO3; MCMBP; UBC; RNF2; NEK9; MCM3; HSP90AB1; HSP90AA1; FKBP5; MAGED2; CAP1; BAG3; CD81; IGSF8; TCEA1; PNKP; VCAM1; ORC5; ORC1; MCM7; MCM2; ITGA4; FN1; CDKN2A; CDC5L; NOTCH1; MYBBP1A; U2AF1; MCM6; MCM4; HNRNPU; APP; FBXO6; NEDD8;