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Datasheets/Manuals | Printable datasheet for anti-CYFIP1 (ARP64537_P050) antibody |
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Tested Species Reactivity | Human |
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Predicted Species Reactivity | Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Zebrafish |
Product Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Clonality | Polyclonal |
Host | Rabbit |
Application | WB |
Reconstitution and Storage | For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Immunogen | The immunogen is a synthetic peptide directed towards the C-terminal region of Human CYFIP1 |
Purification | Affinity Purified |
Predicted Homology Based on Immunogen Sequence | Cow: 100%; Dog: 100%; Goat: 93%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100% |
Peptide Sequence | Synthetic peptide located within the following region: WAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVPLKKMVERI |
Concentration | 0.5 mg/ml |
Blocking Peptide | For anti-CYFIP1 (ARP64537_P050) antibody is Catalog # AAP64537 |
Gene Symbol | CYFIP1 |
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Gene Full Name | Cytoplasmic FMR1 interacting protein 1 |
Alias Symbols | SHYC, SRA1, SRA-1, P140SRA-1 |
NCBI Gene Id | 23191 |
Protein Name | Cytoplasmic FMR1-interacting protein 1 |
Description of Target | CYFIP1 is a component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. CYFIP1 promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA By similarity. CYFIP1 regulates formation of membrane ruffles and lamellipodia. CYFIP1 plays a role in axon outgrowth. CYFIP1 binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. CYFIP1 may act as an invasion suppressor in cancers. |
Uniprot ID | Q7L576 |
Protein Accession # | NP_055423 |
Nucleotide Accession # | NM_014608 |
Protein Size (# AA) | 1253 |
Molecular Weight | 145kDa |
Protein Interactions | EFHC2; SUMO2; MEOX1; UBC; WWOX; PRPF40A; CLUH; TCERG1; NCKAP1; ARHGEF1; GAS7; APBB1; HECW2; RFX6; EFTUD2; SCTR; PPP1CC; GNB1; UBD; MARK4; YWHAZ; YWHAH; RYK; TERF2; TERF1; CYFIP1; RAC1; FMR1; ACTA1; FXR2; FXR1; NCL; |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "CYFIP1 Antibody - C-terminal region (ARP64537_P050)"?
The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Zebrafish".
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How long will it take to receive "CYFIP1 Antibody - C-terminal region (ARP64537_P050)"?
This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".
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What buffer format is "CYFIP1 Antibody - C-terminal region (ARP64537_P050)" provided in?
This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "CYFIP1 Antibody - C-terminal region (ARP64537_P050)"?
This target may also be called "SHYC, SRA1, SRA-1, P140SRA-1" in publications.
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What is the shipping cost for "CYFIP1 Antibody - C-terminal region (ARP64537_P050)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "CYFIP1 Antibody - C-terminal region (ARP64537_P050)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "CYFIP1 Antibody - C-terminal region (ARP64537_P050)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "145kDa".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "CYFIP1 Antibody - C-terminal region (ARP64537_P050)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "CYFIP1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "CYFIP1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "CYFIP1"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "CYFIP1"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "CYFIP1"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "CYFIP1"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.