Catalog No: ARP48251_P050
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ARP48251_P050
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Datasheets/ManualsPrintable datasheet for anti-BAG3 (ARP48251_P050) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the middle region of human BAG3
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
Peptide SequenceSynthetic peptide located within the following region: NVTRPAAQPSFHQAQKTHYPAQQGEYQTHQPVYHKIQGDDWEPRPLRAAS
Concentration0.5 mg/ml
Blocking PeptideFor anti-BAG3 (ARP48251_P050) antibody is Catalog # AAP48251 (Previous Catalog # AAPS23112)
Sample Type Confirmation

BAG3 is supported by BioGPS gene expression data to be expressed in HT1080

ReferenceFranceschelli,S., (2008) J. Cell. Physiol. 215 (3), 575-577
Gene SymbolBAG3
Gene Full NameBCL2-associated athanogene 3
Alias SymbolsBIS, MFM6, BAG-3, CAIR-1
NCBI Gene Id9531
Protein NameBAG family molecular chaperone regulator 3
Description of TargetBAG3 inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. BAG3 has anti-apoptotic activity.BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Uniprot IDO95817
Protein Accession #NP_004272
Nucleotide Accession #NM_004281
Protein Size (# AA)575
Molecular Weight61kDa
Protein InteractionsSF3B4; DAZAP2; ARRDC3; LITAF; MAGED1; PDE9A; HSPA8; PHLDB1; HSPB1; HSF1; STUB1; DNAJB6; AMOT; PDLIM7; MLF2; HSPB8; WBP2; UBC; MCM7; HSP90AB1; ETFA; MVP; ACLY; PSAP; PSME1; PSMD12; PSMD9; PSMD8; PSMD5; PSMD3; PSMD2; PSMC5; PSMC3; PSMC2; PSMC1; PSMB5; PSMB4
  1. What is the species homology for "BAG3 Antibody - middle region (ARP48251_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit".

  2. How long will it take to receive "BAG3 Antibody - middle region (ARP48251_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "BAG3 Antibody - middle region (ARP48251_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "BAG3 Antibody - middle region (ARP48251_P050)"?

    This target may also be called "BIS, MFM6, BAG-3, CAIR-1" in publications.

  5. What is the shipping cost for "BAG3 Antibody - middle region (ARP48251_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "BAG3 Antibody - middle region (ARP48251_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "BAG3 Antibody - middle region (ARP48251_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "61kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "BAG3 Antibody - middle region (ARP48251_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "BAG3"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "BAG3"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "BAG3"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "BAG3"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "BAG3"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "BAG3"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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