TYMS Antibody - C-terminal region (ARP48543_P050)

Catalog No: ARP48543_P050

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WB Suggested Anti-TYMS Antibody Titration: 0.2-1 ug/ml
Positive Control: Jurkat cell lysateTYMS is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human TYMS
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Horse: 86%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 93%; Rat: 100%
• Peptide Sequence: Synthetic peptide located within the following region: HIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKME
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-TYMS (ARP48543_P050) antibody is Catalog # AAP48543 (Previous Catalog # AAPY01487)
• Sample Type Confirmation:

  TYMS is strongly supported by BioGPS gene expression data to be expressed in Jurkat

• Reference: Ikeda,S., (2008) Am. J. Gastroenterol. 103 (6), 1476-1487

Target Info

• Gene Symbol: TYMS
• Gene Full Name: Thymidylate synthetase
• Alias Symbols: TS, TMS, HST422
• NCBI Gene Id: 7298
• Protein Name: Thymidylate synthase
• Description of Target: TYMS catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs.Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-47 CR601528.1 1-47 48-1099 X02308.1 14-1065 1100-1603 BC083512.1 1067-1570
• Uniprot ID: P04818
• Protein Accession #: NP_001062
• Nucleotide Accession #: NM_001071
• Protein Size (# AA): 313
• Molecular Weight: 36kDa
• Protein Interactions: UBC; NEDD8; PLS3; GOT1; EIF5A; DCK; MAPK14; SBDS; UPF2; VCAM1; ITGA4; UNK; ZFYVE19; TXNDC17; ZFYVE21; UBQLN4; WDR45B; UFC1; UBXN7; UBE2C; AHCYL1; SSSCA1; WDR1; VPS4B; ZRANB2; UBE2M; UBE2B; UBE2A; PSMA5; PGAM1; IGBP1; UBE2K; ATP6V1E1; ATP6V1C1; ATIC; ADSL;