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Datasheets/Manuals | Printable datasheet for anti-UBR1 (ARP43459_P050) antibody |
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Tested Species Reactivity | Human |
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Predicted Species Reactivity | Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit |
Product Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Clonality | Polyclonal |
Host | Rabbit |
Application | WB |
Reconstitution and Storage | For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Immunogen | The immunogen is a synthetic peptide directed towards the N terminal region of human UBR1 |
Purification | Affinity Purified |
Predicted Homology Based on Immunogen Sequence | Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 100%; |
Peptide Sequence | Synthetic peptide located within the following region: YKQLQKEYISDDHDRSISITALSVQMFTVPTLARHLIEEQNVISVITETL |
Concentration | 0.5 mg/ml |
Blocking Peptide | For anti-UBR1 (ARP43459_P050) antibody is Catalog # AAP43459 (Previous Catalog # AAPS15304) |
Reference | Yamaguchi,Y., (er) BMC Med. Genet. 9 (1), 22 (2008) In press |
Gene Symbol | UBR1 |
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Gene Full Name | Ubiquitin protein ligase E3 component n-recognin 1 |
Alias Symbols | JBS |
NCBI Gene Id | 197131 |
Protein Name | E3 ubiquitin-protein ligase UBR1 |
Description of Target | UBR1 is an E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. UBR1 may be involved in pancreatic homeostasis.The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
Uniprot ID | Q8IWV7 |
Protein Accession # | NP_777576 |
Nucleotide Accession # | NM_174916 |
Protein Size (# AA) | 1749 |
Molecular Weight | 200kDa |
Protein Interactions | CDC6; UBC; SHFM1; UBE2D1; CBX8; ZNF593; DNPH1; USP5; XPO1; PFAS; CSE1L; ATP6V1A; VCL; UCHL3; CUL2; RECQL4; TIRAP; DNAJB11; NUDT3; SPRY2; LAMTOR3; UBE2A; GSK3B; GADD45A; BCL2L1; UBE2Z; NSFL1C; UBXN1; UBXN7; FAF2; FAF1; FOS; HNRNPA1; NDUFA4L2; ARL15; BTBD2; |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "UBR1 Antibody - N-terminal region (ARP43459_P050)"?
The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit".
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How long will it take to receive "UBR1 Antibody - N-terminal region (ARP43459_P050)"?
This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".
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What buffer format is "UBR1 Antibody - N-terminal region (ARP43459_P050)" provided in?
This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "UBR1 Antibody - N-terminal region (ARP43459_P050)"?
This target may also be called "JBS" in publications.
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What is the shipping cost for "UBR1 Antibody - N-terminal region (ARP43459_P050)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "UBR1 Antibody - N-terminal region (ARP43459_P050)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "UBR1 Antibody - N-terminal region (ARP43459_P050)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "200kDa".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "UBR1 Antibody - N-terminal region (ARP43459_P050)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "UBR1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "UBR1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "UBR1"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "UBR1"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "UBR1"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "UBR1"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.