Catalog No: ARP43025_T100
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ARP43025_T100
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Datasheets/ManualsPrintable datasheet for anti-UBE2L3 (ARP43025_T100) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationIHC, WB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the C terminal region of human UBE2L3
PurificationProtein A purified
Predicted Homology Based on Immunogen SequenceCow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
Peptide SequenceSynthetic peptide located within the following region: TDQVIQSLIALVNDPQPEHPLRADLAEEYSKDRKKFCKNAEEFTKKYGEK
Concentration1.0 mg/ml
Blocking PeptideFor anti-UBE2L3 (ARP43025_T100) antibody is Catalog # AAP43599 (Previous Catalog # AAPS13802)
Sample Type Confirmation

There is BioGPS gene expression data showing that UBE2L3 is expressed in Jurkat

ReferenceYao,Y.L. (2003) J. Biol. Chem. 278 (43), 42560-42568
Gene SymbolUBE2L3
Gene Full NameUbiquitin-conjugating enzyme E2L 3
Alias SymbolsE2-F1, L-UBC, UBCH7, UbcM4
NCBI Gene Id7332
Protein NameUbiquitin-conjugating enzyme E2 L3
Description of TargetThe modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). UBE2L3 is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro.This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacteylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.
Uniprot IDP68036
Protein Accession #NP_003338
Nucleotide Accession #NM_004739
Protein Size (# AA)668
Molecular Weight75kDa
Protein InteractionsUBC; TRAF6; NEDD4; ITCH; MUL1; SMURF2; SMURF1; WWP2; WWP1; ARIH2; RNF144A; UBA1; PARK2; RNF144B; HACE1; ARIH1; UBE3A; UBE2L3; UBA6; UBR5; CACNA1B; MAP1LC3B; BAG3; HSPA4; AICDA; CCNB1IP1; FN1; RBX1; LIG4; ZPR1; USP9X; SF1; VDAC2; UCHL3; UBE2V2; UBE2D2; UBE
  1. What is the species homology for "UBE2L3 Antibody - C-terminal region (ARP43025_T100)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish".

  2. How long will it take to receive "UBE2L3 Antibody - C-terminal region (ARP43025_T100)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "UBE2L3 Antibody - C-terminal region (ARP43025_T100)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "UBE2L3 Antibody - C-terminal region (ARP43025_T100)"?

    This target may also be called "E2-F1, L-UBC, UBCH7, UbcM4" in publications.

  5. What is the shipping cost for "UBE2L3 Antibody - C-terminal region (ARP43025_T100)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "UBE2L3 Antibody - C-terminal region (ARP43025_T100)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "UBE2L3 Antibody - C-terminal region (ARP43025_T100)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "75kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "UBE2L3 Antibody - C-terminal region (ARP43025_T100)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "UBE2L3"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "UBE2L3"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "UBE2L3"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "UBE2L3"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "UBE2L3"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "UBE2L3"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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