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Datasheets/Manuals | Printable datasheet for anti-MOB1A (ARP65686_P050) antibody |
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Tested Species Reactivity | Human |
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Predicted Species Reactivity | Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
Product Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Clonality | Polyclonal |
Host | Rabbit |
Application | WB |
Reconstitution and Storage | For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Immunogen | The immunogen is a synthetic peptide directed towards the C-terminal region of Human MOB1A |
Purification | Affinity Purified |
Predicted Homology Based on Immunogen Sequence | Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93% |
Peptide Sequence | Synthetic peptide located within the following region: FDSVMQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLGSKDR |
Concentration | 0.5 mg/ml |
Blocking Peptide | For anti-MOB1A (ARP65686_P050) antibody is Catalog # AAP65686 |
Gene Symbol | MOB1A |
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Gene Full Name | MOB kinase activator 1A |
Alias Symbols | MOB1, MATS1, Mob4B, C2orf6, MOBK1B, MOBKL1B |
NCBI Gene Id | 55233 |
Protein Name | MOB kinase activator 1A |
Description of Target | MOB1A is an activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. MOB1A stimulates the kinase activity of STK38 and STK38L. MOB1A acts cooperatively with STK3/MST2 to activate STK38. |
Uniprot ID | Q9H8S9 |
Protein Accession # | NP_060691 |
Nucleotide Accession # | NM_018221 |
Protein Size (# AA) | 216 |
Molecular Weight | 25kDa |
Protein Interactions | FAM9B; CMTM3; SEPT3; FAM118A; KANK2; TDO2; UBC; HECW2; ANKRD52; AMOT; ANKRD44; DOCK7; LRCH3; RASSF5; DOCK8; MOB2; SAV1; LRCH2; DOCK6; THOC2; PPP6R3; CRLF3; IPO11; LATS2; ANKRD28; LRCH1; STK38L; PPP6R1; RASSF2; PPP6R2; LATS1; YWHAH; STK4; STK3; PTPN14; PPP |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "MOB1A Antibody - C-terminal region (ARP65686_P050)"?
The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish".
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How long will it take to receive "MOB1A Antibody - C-terminal region (ARP65686_P050)"?
This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".
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What buffer format is "MOB1A Antibody - C-terminal region (ARP65686_P050)" provided in?
This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "MOB1A Antibody - C-terminal region (ARP65686_P050)"?
This target may also be called "MOB1, MATS1, Mob4B, C2orf6, MOBK1B, MOBKL1B" in publications.
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What is the shipping cost for "MOB1A Antibody - C-terminal region (ARP65686_P050)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "MOB1A Antibody - C-terminal region (ARP65686_P050)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "MOB1A Antibody - C-terminal region (ARP65686_P050)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "25kDa".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "MOB1A Antibody - C-terminal region (ARP65686_P050)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "MOB1A"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "MOB1A"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "MOB1A"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "MOB1A"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "MOB1A"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "MOB1A"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.