EIF5A Antibody - N-terminal region (ARP70188_P050)

Catalog No: ARP70188_P050

Host: Rabbit
Target Name: EIF5A
Sample Type: NCI-H226 Whole Cell lysates
Antibody Dilution: 1.0ug/mlThere is BioGPS gene expression data showing that EIF5A is expressed in NCIH226

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human EIF5A
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 93%
• Peptide Sequence: Synthetic peptide located within the following region: LKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVP
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-EIF5A (ARP70188_P050) antibody is Catalog # AAP70188
• Sample Type Confirmation:

  There is BioGPS gene expression data showing that EIF5A is expressed in NCIH226

Target Info

• Gene Symbol: EIF5A
• Alias Symbols: EIF-5A, EIF5A1, eIF-4D, eIF5AI
• NCBI Gene Id: 1984
• Protein Name: Eukaryotic translation initiation factor 5A-1
• Description of Target: EIF5A is a mRNA-binding protein involved in translation elongation. It has an important function at the level of mRNA turnover, probably acting downstream of decapping. It is involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, EIF5A functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. EIF5A regulates also TNF-alpha-mediated apoptosis and mediates effects of polyamines on neuronal process extension and survival. It may play an important role in brain development and function, and in skeletal muscle stem cell differentiation. EIF5A is also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts.
• Uniprot ID: P63241-2
• Protein Size (# AA): 184
• Molecular Weight: 20kDa
• Protein Interactions: HUWE1; UBC; REL; MEOX2; DHPS; CRX; DCP2; STUB1; BCCIP; WDR1; GDA; TYMS; PEPD; MVD; HSPD1; GNS; GLS; UBD; NPM1; IQCB1; ATF2; VCP; MACF1; DDX17; VAPA; XPO1; ATP5B; XPO4; CUL2; COPS5; TCF3; ELAVL1; SUMO2; VHL; Pds5a; Csnk1e; DOHH; XRN2; RPL5; TGM2;