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Datasheets/Manuals | Printable datasheet for anti-UIMC1 (ARP75596_P050) antibody |
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Tested Species Reactivity | Human |
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Predicted Species Reactivity | Human |
Product Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Clonality | Polyclonal |
Host | Rabbit |
Application | WB |
Reconstitution and Storage | For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Immunogen | The immunogen is a synthetic peptide directed towards the middle region of Human UIMC1 |
Purification | Affinity purified |
Peptide Sequence | Synthetic peptide located within the following region: GEQASEKNECISEDMGDEDKEERQESRASDWHSKTKDFQESSIKSLKEKL |
Concentration | 0.5 mg/ml |
Blocking Peptide | For anti-UIMC1 (ARP75596_P050) antibody is Catalog # AAP75596 |
Reference | N/A |
Gene Symbol | UIMC1 |
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Alias Symbols | RAP80, X2HRIP110 |
NCBI Gene Id | 51720 |
Description of Target | UIMC1 is a ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. It plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. It also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. It may interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. And it may indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. |
Uniprot ID | Q96RL1 |
Protein Size (# AA) | 719 |
Molecular Weight | 79kDa |
Protein Interactions | HIST2H2AC; UBC; FANCG; RPS6; HSPA4; CDK1; C1QBP; BRCA1; FAM175A; BRCC3; ELC1; ELA1; BLM; SKIL; SUMO1; SUMO2; MDC1; PAXIP1; Cep57; BRE; HIST2H2BE; ESR1; ATP8A2; KIAA0368; RBBP8; RAD23A; BABAM1; TP53; MDM2; SSU72; FAM175B; ERP44; G3BP1; G3BP2; SPATA2; BAG5; |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "UIMC1 Antibody - middle region (ARP75596_P050)"?
The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human".
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How long will it take to receive "UIMC1 Antibody - middle region (ARP75596_P050)"?
This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".
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What buffer format is "UIMC1 Antibody - middle region (ARP75596_P050)" provided in?
This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "UIMC1 Antibody - middle region (ARP75596_P050)"?
This target may also be called "RAP80, X2HRIP110" in publications.
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What is the shipping cost for "UIMC1 Antibody - middle region (ARP75596_P050)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "UIMC1 Antibody - middle region (ARP75596_P050)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "UIMC1 Antibody - middle region (ARP75596_P050)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "79kDa".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "UIMC1 Antibody - middle region (ARP75596_P050)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "UIMC1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "UIMC1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "UIMC1"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "UIMC1"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "UIMC1"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "UIMC1"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.