Catalog No: ARP68995_P050
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ARP68995_P050
Availability: Domestic: within 1-2 days delivery | International: 1-2 days
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SPRTN Antibody - middle region (ARP68995_P050)

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Datasheets/ManualsPrintable datasheet for anti-SPRTN (ARP68995_P050) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the middle region of Human SPRTN
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 100%; Dog: 100%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 92%; Pig: 100%; Rabbit: 92%; Rat: 100%
Peptide SequenceSynthetic peptide located within the following region: ATNREPSAHDYWWAEHQKTCGGTYIKIKEPENYSKKGKGKAKLGKEPVLA
Concentration0.5 mg/ml
Blocking PeptideFor anti-SPRTN (ARP68995_P050) antibody is Catalog # AAP68995
Gene SymbolSPRTN
Alias SymbolsDVC1, PRO4323, spartan, C1orf124
NCBI Gene Id83932
Protein NameSprT-like domain-containing protein Spartan
Description of TargetSPRTN is a regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis. SPRTN is recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. It facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. It is also required for localization of DNA polymerase eta (POLH) to sites of UV damage.
Uniprot IDQ9H040
Protein Accession #NP_114407
Nucleotide Accession #NM_032018
Protein Size (# AA)489
Molecular Weight55kDa
Protein InteractionsH2BFS; UBR5; FAM120A; STRAP; CKAP4; MAGED2; HIST2H2BF; HIST1H2BK; POLD4; ZC3HAV1; POLD3; DDX17; SYNCRIP; TRIM28; LRPPRC; HUWE1; HNRNPDL; AKAP12; RBM39; H1FX; HIST1H2BH; HIST1H2BM; HIST1H2BN; HIST1H2BL; HIST1H2BG; VIM; VDAC1; UBB; TUFM; DNAJC7; TMPO; STAU1
  1. What is the species homology for "SPRTN Antibody - middle region (ARP68995_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit".

  2. How long will it take to receive "SPRTN Antibody - middle region (ARP68995_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "SPRTN Antibody - middle region (ARP68995_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "SPRTN Antibody - middle region (ARP68995_P050)"?

    This target may also be called "DVC1, PRO4323, spartan, C1orf124" in publications.

  5. What is the shipping cost for "SPRTN Antibody - middle region (ARP68995_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "SPRTN Antibody - middle region (ARP68995_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "SPRTN Antibody - middle region (ARP68995_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "55kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "SPRTN Antibody - middle region (ARP68995_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "SPRTN"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "SPRTN"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "SPRTN"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "SPRTN"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "SPRTN"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "SPRTN"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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