MYC antibody - N-terminal region (ARP32708_P050)

Catalog#: ARP32708_P050

• Size: 50ug

Transfected 293T

Human Muscle

• Description of Target: MYC is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this MYC gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma.The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
• Gene Symbol: MYC
• Official Gene Full Name: V-myc myelocytomatosis viral oncogene homolog (avian)
• Alias Symbols: c-Myc; MRTL; bHLHe39
• Protein Accession#: NP_002458
• Nucleotide Accession#: NM_002467
• Swissprot Id: P01106
• Host: Rabbit
• Clonality: Polyclonal
• Protein Size (# AA): 454
• Molecular Weight: 50kDa
• Application: WB, IHC
• Partner Proteins: CDK1, PLK1, PIN1
• Immunogen: The immunogen for anti-MYC antibody: synthetic peptide directed towards the N terminal of human MYC
• Product Format: Lyophilized powder
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Guinea pig: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Dog: 92%; Rat: 92%; Sheep: 92%; Bovine: 85%
• Peptide Sequence: Synthetic peptide located within the following region: MDFFRVVENQQPPATMPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQ
• Blocking Peptide: For anti-MYC antibody is Catalog # AAP32708 (Previous Catalog # AAPP03722)
• Key Reference: Frater,J.L., (2006) Cancer Genet. Cytogenet. 166 (2), 139-145
• Reconstitution and Storage: Add 50 μl of distilled water. Final anti-MYC antibody concentration is 1 mg/ml in PBS buffer. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.

Product Protocols: MYC antibody tested with Human Transfected 293T Cells (ARP32708_P050)

Aviva Systems Biology is the original manufacturer of this MYC antibody (ARP32708_P050)

Click here to view the MYC antibody Western Blot Protocol

Product Datasheet Link: MYC antibody (ARP32708_P050)

WB Suggested Anti-MYC Antibody Titration: 0.0625ug/ml
Positive Control: Transfected 293T

Western Blot image:


Description of Target: MYC is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this MYC gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma.The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.

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Aviva Systems Biology’s MYC antibody (ARP32708_P050) has been tested using other cell lysates and tissues. To obtain more data about this antibody please email us at info@avivasysbio.com.

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Product Protocols: MYC antibody tested by IHC with human muscle (ARP32708)

Aviva Systems Biology is the original manufacturer of this MYC antibody.

Click here to view the MYC antibody Immunohistochemistry (IHC) protocol

Product Datasheet Link: MYC antibody (ARP32708)

IHC Information:

Rabbit Anti-MYC Antibody
Catalog Number: ARP32708
Paraffin Embedded Tissue: Human Muscle
Cellular Data: Skeletal muscle cells
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X

IHC Image: