EXOSC9 Antibody - N-terminal region (ARP62142_P050)

Catalog No: ARP62142_P050

WB Suggested Anti-EXOSC9 Antibody
Titration: 1.0 ug/ml
Positive Control: Fetal Heart

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
• Peptide Sequence: Synthetic peptide located within the following region: ERRFLLRAIEEKKRLDGRQTYDYRNIRISFGTDYGCCIVELGKTRVLGQV
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-EXOSC9 (ARP62142_P050) antibody is Catalog # AAP62142 (Previous Catalog # AAPP48460)

Target Info

• Gene Symbol: EXOSC9
• Gene Full Name: Exosome component 9
• Alias Symbols: p5, p6, PCH1D, RRP45, PMSCL1, Rrp45p, PM/Scl-75
• NCBI Gene Id: 5393
• Protein Name: Exosome complex component RRP45
• Description of Target: EXOSC9 is a non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs.
• Uniprot ID: Q06265
• Protein Accession #: NP_005024
• Nucleotide Accession #: NM_005033
• Protein Size (# AA): 355
• Molecular Weight: 39kDa
• Protein Interactions: UBC; EXOSC4; MPG; AICDA; CSNK2A1; EXOSC5; EXOSC10; EXOSC3; EXOSC2; DIS3; DIS3L; CHMP4B; CAND1; COPS5; CUL3; SUMO2; UBE2I; EXOSC1; SKIV2L2; EXOSC6; DDX39A; MPP6; EXOSC7; EXOSC8; EXOSC9; DDX39B;