ESR1 Antibody - middle region (ARP45592_P050)

Catalog No: ARP45592_P050

WB Suggested Anti-ESR1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Hela cell lysate

Host: Rabbit
Target Name: ESR1
Sample Type: Human Adult Placenta
Antibody Dilution: 1.0ug/ml

Host: Rabbit
Target Name: ESR1
Sample Type: Human Fetal Muscle
Antibody Dilution: 1.0ug/ml

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Rat, Cow, Dog, Pig, Sheep
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ESR1
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 83%; Dog: 79%; Human: 100%; Pig: 79%; Rat: 86%; Sheep: 79%
• Peptide Sequence: Synthetic peptide located within the following region: LLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAE
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-ESR1 (ARP45592_P050) antibody is Catalog # AAP45592 (Previous Catalog # AAPP11871)
• Reference: Giegling,I., (2008) Psychiatry Res 160 (1), 1-7

Target Info

• Gene Symbol: ESR1
• Gene Full Name: Estrogen receptor 1
• Alias Symbols: ER, ESR, Era, ESRA, ESTRR, NR3A1
• NCBI Gene Id: 2099
• Protein Name: Estrogen receptor
• Description of Target: Hairy/enhancer of split-related proteins, such as HEY1, are basic helix-loop-helix (bHLH) transcription factors implicated in cell fate decision and boundary formation. HEY genes are direct transcriptional targets of the Notch signaling pathways in Drosophila and vertebrates. This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.
• Uniprot ID: P03372
• Protein Accession #: NP_000116
• Nucleotide Accession #: NM_000125
• Protein Size (# AA): 595
• Molecular Weight: 66kDa
• Protein Interactions: SRC; DDX5; POLR2C; POLR2B; POLR2A; MSH2; TTC5; KAT5; NCOA2; BRCA1; MED24; UBC; PSMB9; MED1; POLR2L; POLR2K; POLR2J; POLR2I; POLR2H; POLR2G; POLR2F; POLR2E; POLR2D; ASCC1; TRRAP; PHB2; NCOR1; NCOA1; PIK3CA; IGF1R; HDAC1; NSD1; WIPI1; ESR1; ZNF131; RANBP9;