CAND1 Antibody - middle region (ARP34584_P050)

Catalog No: ARP34584_P050

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WB Suggested Anti-CAND1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: HepG2 cell lysate

WB Suggested Anti-CAND1 Antibody
Titration: 1 ug/ml
Positive Control: mouse testis

Product Info

• Tested Species Reactivity: Human, Mouse
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CAND1
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%
• Peptide Sequence: Synthetic peptide located within the following region: AALLTIPEAEKSPLMSEFQSQISSNPELAAIFESIQKDSSSTNLESMDTS
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-CAND1 (ARP34584_P050) antibody is Catalog # AAP34584 (Previous Catalog # AAPP23612)
• Reference: Min,K.W., (2005) Biochem. Biophys. Res. Commun. 334 (3), 867-874

Target Info

• Gene Symbol: CAND1
• Gene Full Name: Cullin-associated and neddylation-dissociated 1
• Alias Symbols: TIP120, TIP120A
• NCBI Gene Id: 55832
• Protein Name: Cullin-associated NEDD8-dissociated protein 1
• Description of Target: CAND1 enhances transcription from various types of promoters. It is a regulatory protein that interferes with the assembly of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex and thereby down-regulates ubiquitination of target proteins. CAND1 prevents neddylation of CUL1 by physically blocking access to the neddylation site. CAND1 disrupts interactions between CUL1 and SKP1A and between CUL1 and F-box proteins.
• Uniprot ID: Q86VP6
• Protein Accession #: NP_060918
• Nucleotide Accession #: NM_018448
• Protein Size (# AA): 1230
• Molecular Weight: 136kDa
• Protein Interactions: ISG15; SUMO2; SUMO3; UBE2D1; UBC; UBE2M; CUL1; ASB2; ASB1; PPM1G; PAWR; OSBP; KARS; GARS; CARS; APEH; STAT1; SHMT2; IPO7; SEC23A; JMJD6; HSPA4; TRMT112; ZYX; DCUN1D5; DCUN1D1; SRPK2; UBD; FBXL3; FN1; CFTR; vif; CA9; ECT2; NOTCH1; CUL4A; CUL5; RBX1; ERCC6;