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Now Offering Over 85,203 Antibodies & 34,301 Antigens!

Cell Cycle Pathway

The cell cycle pathway is a unidirectional process that governs cell division. This process, which cannot be reversed once started, is critical for cell survival. The cell cycle typically involves four phases: S phase, in which DNA is replicated, M phase, in which chromosomes are separated and two distinct cells are formed, and G1 and G2 phases during which the cell is preparing for cell division. The majority of the cell cycle pathway is regulated by two classes of proteins: cyclin-dependent kinases (CDKs) and cyclins. Cyclins and CDKs form complexes that enable CDKs to phosphorylate and activate specific cell cycle intermediates. In the initial stages of the cell-cycle signal, cyclin D will bind to CDK4 and this complex will phosphorylate the retinoblastoma (Rb) gene[1]. During a quiescent state, Rb is bound to DNA and blocks the transcription of specific genes. After phosphorylation, Rb becomes unbound and genes necessary for the cell cycle are now accessible.

The cell cycle pathway is a highly-regulated process that incorporates three major checkpoints. The first checkpoint is the G1 checkpoint, which determines whether or not a cell will enter into the cell division process. The second checkpoint, G2, will determine if the cell will enter into mitosis. Both the G1 and G2 checkpoints can be affected by the presence or absence of various growth factors, DNA damage, or replicative senescence. The final checkpoint, metaphase, ensures proper chromosome alignment prior to cell division. The cell cycle pathway is intrinsically linked to cell survival and cell death. For instance, failure of a cell to meet the requirements of the individual cell cycle checkpoints will result in the cell undergoing apoptosis.

In cancer, the cell cycle checkpoints are often dysfunctional. Checkpoint proteins, such as Rb or p53, are often mutated or inactivated and this can result in cell division despite incomplete DNA synthesis and segregation errors. Inappropriate continuation of the cell cycle can lead to genomic instability, which is a common feature of malignant cells.

1. Nigg. 1995. Cyclin-dependent protein kinases: key regulators of the eukaryotic cell cycle. Bioessays. 17(6):471-80.

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Cell Cycle pathway image by Aviva Systems Biology

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Showing 31 - 60 of 60
  Type Catalog # Product Product Images Price (USD)
  pAb ARP56709_P050 Rad21 antibody - N-terminal region (ARP56709_P050)
Reacts with
Mouse, Dog, Human, Pig, Horse, Rabbit, Rat, Guinea pig, Bovine
Application
WB
$289.00
  pAb OASA06933 YWHAH Antibody (OASA06933)
Reacts with
Sheep
Application
WB
$485.00
  mAb OASA03108 MCM5 Antibody (OASA03108)
Reacts with
Human
Application
IHC-FFPE, WB
$440.00
  pAb ARP43603_P050 CDC27 antibody - middle region (ARP43603_P050)
Reacts with
Bovine, Human, Dog, Pig, Horse, Rabbit, Rat, Guinea pig
Application
WB
$289.00
  pAb P100991_P050 CCNH antibody - middle region (P100991_P050)
Reacts with
Bovine, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat
Application
WB
$289.00
  pAb AVARP03045_T100 CCNA2 antibody - C-terminal region (AVARP03045_T100)
Reacts with
Bovine, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
Application
WB
$229.00
  pAb P100682_P050 RBL1 antibody - N-terminal region (P100682_P050)
Reacts with
Bovine, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat
Application
WB
$289.00
  pAb ARP43169_P050 ANAPC10 antibody - N-terminal region (ARP43169_P050)
Reacts with
Rat, Pig, Human, Dog, Bovine, Horse, Rabbit, Guinea pig, Mouse, Zebrafish
Application
WB
$289.00
  pAb ARP36667_T100 MCM7 antibody - middle region (ARP36667_T100)
Reacts with
Human, Mouse, Dog, Horse, Rabbit, Rat, Guinea pig, Bovine, Zebrafish
Application
WB
$229.00
  pAb ARP45446_P050 TGFB2 antibody - middle region (ARP45446_P050)
Reacts with
Human, Dog, Horse, Rabbit, Rat, Pig, Bovine, Mouse, Sheep, Zebrafish, Guinea pig
Application
WB
$289.00
  pAb P100920_P050 E2F5 antibody - N-terminal region (P100920_P050)
Reacts with
Dog, Guinea pig, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
Application
WB
$289.00
  pAb AVARP03044_P050 CCNE2 antibody - N-terminal region (AVARP03044_P050)
Reacts with
Bovine, Guinea pig, Horse, Human, Mouse, Pig, Rat
Application
WB
$289.00
  mAb OASA03620 PCNA Antibody (OASA03620)
Reacts with
Human
Application
IHC-AFF, FC, IP, IHC-FFPE, WB
$635.00
  pAb ARP50542_P050 PTTG2 antibody - middle region (ARP50542_P050)
Reacts with
Human, Dog, Pig, Bovine, Horse, Rabbit, Mouse
Application
WB
$289.00
  pAb ARP39740_P050 CCNB3 antibody - C-terminal region (ARP39740_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP60167_P050 GADD45A antibody - C-terminal region (ARP60167_P050)
Reacts with
Human, Bovine, Pig, Rabbit, Horse
Application
WB
$289.00
  pAb AVARP03049_T100 CUL1 antibody - C-terminal region (AVARP03049_T100)
Reacts with
Bovine, Dog, Human, Mouse, Rat, Zebrafish
Application
WB
$229.00
  pAb AVARP03034_P050 CDC25C antibody - N-terminal region (AVARP03034_P050)
Reacts with
Human, Mouse, Rabbit
Application
WB
$289.00
  pAb ARP43040_P050 CDC23 antibody - C-terminal region (ARP43040_P050)
Reacts with
Bovine, Dog, Rat, Pig, Horse, Rabbit, Guinea pig, Mouse, Human
Application
WB
$289.00
  pAb ARP51279_P050 FZR1 antibody - N-terminal region (ARP51279_P050)
Reacts with
Zebrafish, Rat, Mouse, Dog, Pig, Horse, Guinea pig, Human, Bovine
Application
WB
$289.00
  pAb P100879_P050 TFDP1 antibody - middle region (P100879_P050)
Reacts with
Bovine, Human, Mouse, Zebrafish
Application
WB
$289.00
  pAb ARP38605_P050 SMAD4 antibody - N-terminal region (ARP38605_P050)
Reacts with
Bovine, Zebrafish, Human, Rat, Mouse, Dog, Horse, Goat, Rabbit, Guinea pig, Sheep
Application
IHC, WB
$289.00
  pAb AVARP02058_P050 YWHAE antibody - middle region (AVARP02058_P050)
Reacts with
Dog, Guinea pig, Mouse, Zebrafish
Application
WB
$289.00
  pAb ARP41605_P050 ANAPC7 antibody - C-terminal region (ARP41605_P050)
Reacts with
Human, Dog, Horse, Rabbit, Rat, Guinea pig, Mouse
Application
IHC, WB
$289.00
  pAb ARP32618_P050 HDAC2 antibody - C-terminal region (ARP32618_P050)
Reacts with
Human, Bovine, Dog, Pig, Rabbit, Rat, Mouse, Horse, Guinea pig, Yeast
Application
IHC, WB
$289.00
  pAb ARP59256_P050 CDC26 antibody - C-terminal region (ARP59256_P050)
Reacts with
Horse, Rat, Guinea pig, Dog, Bovine, Human, Rabbit, Mouse
Application
WB
$289.00
  pAb AVARP03041_P050 CDC25B antibody - N-terminal region (AVARP03041_P050)
Reacts with
Dog, Guinea pig, Horse, Pig, Rabbit
Application
IHC, WB
$289.00
  pAb ARP31175_P050 E2F4 antibody - C-terminal region (ARP31175_P050)
Reacts with
Rat, Bovine, Dog, Pig, Horse, Rabbit, Guinea pig, Human, Zebrafish, Mouse
Application
IHC, WB
$289.00
  pAb ARP33438_T100 TFDP2 antibody - N-terminal region (ARP33438_T100)
Reacts with
Human, Bovine, Horse, Rabbit, Guinea pig, Dog, Rat, Mouse
Application
IHC, WB
$229.00
  pAb ARP48346_P050 GADD45B antibody - middle region (ARP48346_P050)
Reacts with
Dog, Horse, Pig, Human, Mouse, Bovine, Rat, Guinea pig
Application
IHC, WB
$289.00

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Showing 31 - 60 of 60