SETD7 Antibody - N-terminal region (ARP48939_P050)

Catalog No: ARP48939_P050

Host: Rabbit
Target Name: SETD7
Sample Type: Jurkat Whole Cell lysates
Antibody Dilution: 1.0ug/ml

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human SETD7
• Purification: Affinity purified
• Predicted Homology Based on Immunogen Sequence: Cow: 93%; Dog: 93%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 92%
• Peptide Sequence: Synthetic peptide located within the following region: MDSDDEMVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGK
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-SETD7 (ARP48939_P050) antibody is Catalog # AAP48939

Target Info

• Gene Symbol: SETD7
• Gene Full Name: SET domain containing (lysine methyltransferase) 7
• Alias Symbols: KMT7, SET7, SET9, SET7/9
• NCBI Gene Id: 80854
• Protein Name: Histone-lysine N-methyltransferase SETD7
• Description of Target: SETD7 is a histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. It plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
• Uniprot ID: Q8WTS6
• Protein Accession #: NP_085151
• Protein Size (# AA): 366
• Molecular Weight: 40kDa
• Protein Interactions: KLF4; HIST3H3; SOX2; PRKAR1A; A1BG; TP53; NR2F2; STEAP3; SERTAD1; DPY30; MED1; MYOD1; E2F1; HIST1H3A; SMARCA4; H3F3A; STAT3; RELA; AR; UBC; DNMT1; PPP1R12A; SIRT1; TBP; TAF10; TAF7; TAF6; HIST1H4A; ESR1; HIST2H3C; HCFC1; L3MBTL1;