- Description of Target:
- TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
- Gene Symbol:
- TNF
- Alias Symbols:
- APC1 protein; TNF superfamily; member 2; TNF; macrophage-derived; monocyte-derived; TNF-a; cachectin; tumor necrosis factor alpha; tumor necrosis factor ligand superfamily member 2; DIF; TNFA; TNFSF2; TNF-alpha
- Tissue Tool:
- Find tissues and cell lines supported to express TNF.
- Protein Accession# :
- NP_000585
- Nucleotide Accession#:
- NM_00594
- Swissprot Id:
- P01375
- Host:
- Mouse
- Protein Size (# AA):
- 233
- Molecular Weight:
- 26kDa
- Application:
- WB
- Product Format:
- Lyophilized powder
- Isotype:
- Mouse IgG
- Reconstitution and Storage:
- Add 100ul of distilled water. Final anti-TNF antibody concentration is 1 mg/ml in PBS buffer. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
- Key Reference:
- Juran,B.D., et al., Hepatology 52 (1), 223-229 (2010)
- Datasheets / Downloads:
- Printable datasheet for
anti-TNF antibody
- AMM00036
- Protocol:
- Tips Information:
See our General FAQ page.
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