FGA Antibody - N-terminal region (ARP41758_T100)

Catalog No: ARP41758_T100

WB Suggested Anti-FGA Antibody Titration: 5.0ug/ml
Positive Control: Jurkat cell lysate

Rabbit Anti-FGA Antibody
Catalog Number: ARP41758
Paraffin Embedded Tissue: Human Skin
Cellular Data: Squamous epithelial cells
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Goat, Horse, Pig, Sheep
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: IHC, WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human FGA
• Purification: Protein A purified
• Predicted Homology Based on Immunogen Sequence: Cow: 93%; Dog: 86%; Goat: 91%; Horse: 85%; Human: 100%; Mouse: 86%; Pig: 93%; Rat: 91%; Sheep: 91%
• Peptide Sequence: Synthetic peptide located within the following region: MFSMRIVCLVLSVVGTAWTADSGEGDFLAEGGGVRGPRVVERHQSACKDS
• Concentration: 1.0 mg/ml
• Blocking Peptide: For anti-FGA (ARP41758_T100) antibody is Catalog # AAP41758 (Previous Catalog # AAPP10806)
• Reference: Smolarczyk,K., (2005) Arterioscler. Thromb. Vasc. Biol. 25 (12), 2679-2684

Target Info

• Gene Symbol: FGA
• Gene Full Name: Fibrinogen alpha chain
• Alias Symbols: Fib2
• NCBI Gene Id: 2243
• Protein Name: Fibrinogen alpha chain
• Description of Target: FGA is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in its gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis.The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus.
• Uniprot ID: Q4QQH7
• Protein Accession #: NP_068657
• Nucleotide Accession #: NM_021871
• Protein Size (# AA): 644
• Molecular Weight: 71kDa
• Protein Interactions: ASB7; ASB6; FN1; APOA1; ALB; UBC; SUMO2; MIS12; KHDRBS2; ITGA2B; SERPINA5; CDH5; SERPINF2; THBS1; F2; ITGB3; PLAT; HRG; PRRC2A; FGG; FGB; FGA; F13A1; NID1;