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Axon Guidance Pathway

Axon guidance refers to the process by which growing neural axons follow specific, predictable paths to reach their target locations. The tip of the growing axon is known as the growth cone and it is this part of the axon that senses guidance cues (also known as guidance factors) in the surrounding environment. The growth cone receptors respond to the various fixed and diffusible guidance cues and their gradients and respond accordingly. The response is in the form of directional changes in axon growth mediated by cytoskeletal changes. A broad array of signals can function as guidance cues, some of the most well-studied being Netrins, Ephrins and Semaphorins. Each guidance factor serves to attract or repel growth cones during neural development, although different cues can have diverse effects on distinct growth cones. It is the collective influence of the various cues that helps guide axons to their appropriate targets during development. The effects of guidance cues on axon growth can readily be studied in vitro with an array of commercially available factors. Elucidation of the processes that promote and inhibit axon growth during development may provide critical insights into neuroregenerative processes that could benefit patients with spinal cord injuries and other diseases of the nervous system[1].

1. Harel NY and Strittmatter SM. 2006. Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury? Nat Rev Neurosci. Aug;7(8):603-16.

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Showing 1 - 30 of 56
  Type Catalog # Product Product Images Price (USD)
  pAb ARP54630_P050 GNAI1 antibody - middle region (ARP54630_P050)
Reacts with
Yeast, Mouse, Human, Rat, Dog, Pig, Rabbit, Bovine, Horse, Guinea pig, Zebrafish, Goat, Sheep
Application
WB
$289.00
  pAb ARP52307_P050 CHP antibody - N-terminal region (ARP52307_P050)
Reacts with
Mouse, Human, Dog, Pig, Horse, Rabbit, Rat, Guinea pig, Bovine, Zebrafish
Application
IHC, WB
$289.00
  pAb ARP49485_P050 SEMA4B antibody - N-terminal region (ARP49485_P050)
Reacts with
Rat, Dog, Mouse, Horse, Rabbit, Guinea pig, Human, Bovine
Application
WB
$289.00
  pAb ARP64264_P050 SPAM1 Antibody - C-terminal region (ARP64264_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP57798_P050 RAC1 antibody - middle region (ARP57798_P050)
Reacts with
Mouse, Zebrafish, Human, Bovine, Sheep, Dog, Horse, Rabbit, Rat, Guinea pig
Application
WB
$289.00
  pAb ARP54632_P050 GNAI2 antibody - C-terminal region (ARP54632_P050)
Reacts with
Goat, Bovine, Human, Sheep, Horse, Rabbit, Rat, Mouse, Guinea pig, Zebrafish, Dog
Application
WB
$289.00
  pAb ARP49645_P050 NTN4 antibody - N-terminal region (ARP49645_P050)
Reacts with
Bovine, Human, Mouse, Dog, Rat, Pig, Horse, Rabbit, Guinea pig
Application
IHC, WB
$289.00
  pAb ARP46421_P050 SEMA4F antibody - N-terminal region (ARP46421_P050)
Reacts with
Bovine, Human, Mouse, Pig, Horse, Rabbit, Rat, Guinea pig, Dog
Application
WB
$289.00
  mAb OASA00074 Itgb1 Antibody (OASA00074)
Reacts with
Mouse
Application
FC, IP
$355.00
  pAb ARP58905_P050 GNAI3 antibody - N-terminal region (ARP58905_P050)
Reacts with
Zebrafish, Rat, Human, Mouse, Dog, Horse, Rabbit, Sheep, Guinea pig, Bovine, Goat
Application
WB
$289.00
  pAb P100975_P050 NFATC3 antibody - N-terminal region (P100975_P050)
Reacts with
Bovine, Dog, Horse, Human, Mouse, Rat
Application
IHC, WB
$289.00
  pAb ARP58521_P050 RHOA antibody - middle region (ARP58521_P050)
Reacts with
Zebrafish, Human, Sheep, Dog, Rabbit, Rat, Guinea pig, Goat, Horse, Bovine, Mouse
Application
WB
$289.00
  pAb ARP49593_P050 LRRC4C antibody - N-terminal region (ARP49593_P050)
Reacts with
Rat, Dog, Pig, Horse, Rabbit, Guinea pig, Human, Mouse, Bovine, Zebrafish
Application
WB
$289.00
  pAb ARP45510_P050 UNC5C antibody - C-terminal region (ARP45510_P050)
Reacts with
Zebrafish, Human, Mouse, Rat, Bovine, Dog, Horse, Rabbit, Guinea pig
Application
WB
$289.00
  pAb ARP58766_P050 SLIT3 antibody - N-terminal region (ARP58766_P050)
Reacts with
Bovine, Dog, Horse, Human, Mouse, Rat, Rabbit, Guinea pig
Application
WB
$289.00
  pAb ARP55526_P050 SEMA3D antibody - middle region (ARP55526_P050)
Reacts with
Rat, Dog, Pig, Horse, Rabbit, Human, Mouse, Bovine
Application
WB
$289.00
  pAb ARP49932_P050 PLXNA2 antibody - N-terminal region (ARP49932_P050)
Reacts with
Rat, Dog, Pig, Horse, Rabbit, Guinea pig, Human, Mouse, Zebrafish
Application
WB
$289.00
  pAb ARP30926_P050 JUN antibody - middle region (ARP30926_P050)
Reacts with
Dog, Horse, Rabbit, Rat, Guinea pig, Goat, Bovine, Human, Mouse, Zebrafish, Sheep
Application
WB
$289.00
  pAb ARP37106_T100 NFATC2 antibody - N-terminal region (ARP37106_T100)
Reacts with
Mouse, Human, Rat, Horse, Bovine, Dog, Pig
Application
WB
$229.00
  pAb ARP59101_P050 NRP1 antibody - N-terminal region (ARP59101_P050)
Reacts with
Bovine, Dog, Human, Pig, Horse, Rabbit, Rat, Guinea pig, Mouse, Zebrafish
Application
WB
$289.00
  pAb ARP58460_P050 EPHA5 antibody - middle region (ARP58460_P050)
Reacts with
Human, Zebrafish, Pig, Mouse, Rat, Bovine, Dog, Horse, Rabbit, Guinea pig
Application
WB
$289.00
  pAb ARP54608_P050 FES antibody - N-terminal region (ARP54608_P050)
Reacts with
Rat, Human, Dog, Pig, Rabbit, Mouse, Bovine, Guinea pig, Zebrafish
Application
WB
$289.00
  pAb ARP49584_P050 SEMA6D antibody - N-terminal region (ARP49584_P050)
Reacts with
Mouse, Zebrafish, Human, Rat, Bovine, Dog, Pig, Horse, Rabbit, Guinea pig
Application
WB
$289.00
  pAb ARP42414_P050 RHOD antibody - C-terminal region (ARP42414_P050)
Reacts with
Dog, Human, Bovine, Rat, Guinea pig, Horse, Mouse
Application
IHC, WB
$289.00
  pAb P100981_P050 NFATC1 antibody - N-terminal region (P100981_P050)
Reacts with
Dog, Guinea pig, Human, Mouse
Application
WB
$289.00
  pAb ARP58765_P050 SLIT1 antibody - middle region (ARP58765_P050)
Reacts with
Human, Bovine, Dog, Pig, Horse, Rabbit, Rat, Guinea pig, Mouse, Zebrafish
Application
IHC, WB
$289.00
  pAb ARP46583_P050 DCC antibody - middle region (ARP46583_P050)
Reacts with
Rat, Dog, Zebrafish, Horse, Rabbit, Guinea pig, Human, Mouse
Application
WB
$289.00
  pAb AVARP01017_P050 CDC42 antibody - N-terminal region (AVARP01017_P050)
Reacts with
Application
WB
$289.00
  pAb ARP56124_P050 PPP3R1 antibody - N-terminal region (ARP56124_P050)
Reacts with
Bovine, Human, Zebrafish, Dog, Pig, Horse, Rabbit, Rat, Guinea pig, Mouse
Application
WB
$289.00
  pAb ARP50294_P050 UNC5A antibody - middle region (ARP50294_P050)
Reacts with
Rat, Bovine, Dog, Pig, Horse, Mouse, Rabbit, Guinea pig, Human, Zebrafish
Application
WB
$289.00

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Showing 1 - 30 of 56