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Axon Guidance Pathway

Axon guidance refers to the process by which growing neural axons follow specific, predictable paths to reach their target locations. The tip of the growing axon is known as the growth cone and it is this part of the axon that senses guidance cues (also known as guidance factors) in the surrounding environment. The growth cone receptors respond to the various fixed and diffusible guidance cues and their gradients and respond accordingly. The response is in the form of directional changes in axon growth mediated by cytoskeletal changes. A broad array of signals can function as guidance cues, some of the most well-studied being Netrins, Ephrins and Semaphorins. Each guidance factor serves to attract or repel growth cones during neural development, although different cues can have diverse effects on distinct growth cones. It is the collective influence of the various cues that helps guide axons to their appropriate targets during development. The effects of guidance cues on axon growth can readily be studied in vitro with an array of commercially available factors. Elucidation of the processes that promote and inhibit axon growth during development may provide critical insights into neuroregenerative processes that could benefit patients with spinal cord injuries and other diseases of the nervous system[1].

1. Harel NY and Strittmatter SM. 2006. Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury? Nat Rev Neurosci. Aug;7(8):603-16.

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Axon Guidance pathway image by Aviva System Biology

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Showing 1 - 30 of 55
  Type Catalog # Product Product Images Price (USD)
  pAb P100981_P050 NFATC1 antibody - N-terminal region (P100981_P050)
Reacts with
Dog, Guinea pig, Human, Mouse
Application
WB
$289.00
  pAb P100975_P050 NFATC3 antibody - N-terminal region (P100975_P050)
Reacts with
Bovine, Dog, Horse, Human, Mouse, Rat
Application
IHC, WB
$289.00
  Protein OPSA11079 HUMAN EPHRIN B2 Recombinant Protein (25ug)
Reacts with
Human
Application
$530.00
  pAb OASA08545 PAK2 antibody - C-terminal region (OASA08545)
Reacts with
Human
Application
WB
$310.00
  pAb OASA07758 PTK2 Antibody (OASA07758)
Reacts with
Human
Application
IHC-FFPE
$750.00
  pAb OASA07724 EPHA4 Antibody (OASA07724)
Reacts with
Human
Application
IHC-FFPE
$750.00
  pAb OASA07320 Gsk3b Antibody (OASA07320)
Reacts with
Rat
Application
WB
$750.00
  pAb OASA07240 Mapk3 Antibody (OASA07240)
Reacts with
Rat
Application
WB
$725.00
  pAb OASA07137 CDK5 antibody - C-terminal region (OASA07137)
Reacts with
Human
Application
ELISA, IP, WB
$395.00
  pAb OASA06686 Cxcl12 Antibody (OASA06686)
Reacts with
Mouse
Application
ELISA, WB
$570.00
  pAb OASA06519 Cxcr4 antibody - N-terminal region (OASA06519)
Reacts with
Mouse
Application
ELISA, IHC-FFPE, WB
$455.00
  pAb OASA06415 RAC2 Antibody (OASA06415)
Reacts with
Human
Application
WB
$560.00
  pAb OASA06111 CFL2 antibody - C-terminal region (OASA06111)
Reacts with
Human
Application
ELISA, WB
$530.00
  mAb OASA02910 HRAS Antibody (OASA02910)
Reacts with
Human
Application
ELISA, WB
$270.00
  mAb OASA02621 MET Antibody (OASA02621)
Reacts with
Human
Application
ELISA, WB
$925.00
  mAb OASA02604 SEMA7A Antibody (OASA02604)
Reacts with
Human
Application
FC, IP, WB
$545.00
  mAb OASA01062 SEMA4D Antibody (OASA01062)
Reacts with
Human
Application
FC, IP, WB
$425.00
  mAb OASA00727 FYN Antibody (OASA00727)
Reacts with
Human
Application
IHC-AFF, IP, WB
$310.00
  mAb OASA00074 Itgb1 Antibody (OASA00074)
Reacts with
Mouse
Application
FC, IP
$355.00
  pAb AVARP09007_T100 RGS3 antibody - C-terminal region (AVARP09007_T100)
Reacts with
Bovine, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat
Application
WB
$229.00
  pAb AVARP01017_P050 CDC42 antibody - N-terminal region (AVARP01017_P050)
Reacts with
Application
WB
$289.00
  pAb ARP65781_P050 LPHN1 Antibody - C-terminal region (ARP65781_P050)
Reacts with
Rat, Mouse, Guinea pig, Human, Bovine, Horse, Dog
Application
WB
$289.00
  pAb ARP64264_P050 SPAM1 Antibody - C-terminal region (ARP64264_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP62762_P050 BRAT1 Antibody - C-terminal region (ARP62762_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP61345_P050 EFNA2 antibody - middle region (ARP61345_P050)
Reacts with
Bovine, Rat, Pig, Guinea pig, Human, Mouse
Application
WB
$289.00
  pAb ARP59101_P050 NRP1 antibody - N-terminal region (ARP59101_P050)
Reacts with
Bovine, Dog, Human, Pig, Horse, Rabbit, Rat, Guinea pig, Mouse, Zebrafish
Application
WB
$289.00
  pAb ARP58905_P050 GNAI3 antibody - N-terminal region (ARP58905_P050)
Reacts with
Zebrafish, Rat, Human, Mouse, Dog, Horse, Rabbit, Sheep, Guinea pig, Bovine, Goat
Application
WB
$289.00
  pAb ARP58766_P050 SLIT3 antibody - N-terminal region (ARP58766_P050)
Reacts with
Bovine, Dog, Horse, Human, Mouse, Rat, Rabbit, Guinea pig
Application
WB
$289.00
  pAb ARP58765_P050 SLIT1 antibody - middle region (ARP58765_P050)
Reacts with
Human, Bovine, Dog, Pig, Horse, Rabbit, Rat, Guinea pig, Mouse, Zebrafish
Application
IHC, WB
$289.00
  pAb ARP58521_P050 RHOA antibody - middle region (ARP58521_P050)
Reacts with
Zebrafish, Human, Sheep, Dog, Rabbit, Rat, Guinea pig, Goat, Horse, Bovine, Mouse
Application
WB
$289.00

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