Axon Guidance Pathway

Axon guidance refers to the process by which growing neural axons follow specific, predictable paths to reach their target locations. The tip of the growing axon is known as the growth cone and it is this part of the axon that senses guidance cues (also known as guidance factors) in the surrounding environment. The growth cone receptors respond to the various fixed and diffusible guidance cues and their gradients and respond accordingly. The response is in the form of directional changes in axon growth mediated by cytoskeletal changes. A broad array of signals can function as guidance cues, some of the most well-studied being Netrins, Ephrins and Semaphorins. Each guidance factor serves to attract or repel growth cones during neural development, although different cues can have diverse effects on distinct growth cones. It is the collective influence of the various cues that helps guide axons to their appropriate targets during development. The effects of guidance cues on axon growth can readily be studied in vitro with an array of commercially available factors. Elucidation of the processes that promote and inhibit axon growth during development may provide critical insights into neuroregenerative processes that could benefit patients with spinal cord injuries and other diseases of the nervous system^[1].

1. Harel NY and Strittmatter SM. 2006. Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury? Nat Rev Neurosci. Aug;7(8):603-16.

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Type	Catalog #	Product	Product Images	Price (USD)
pAb	P100981_P050	NFATC1 antibody - N-terminal region (P100981_P050) Reacts with Human, Dog, Mouse, Guinea pig Application WB	Human Stomach	$289.00
pAb	P100975_P050	NFATC3 antibody - N-terminal region (P100975_P050) Reacts with Bovine, Chicken, Dog, Horse, Human, Mouse, Rat, African clawed frog Application WB, IHC	Human HeLa Human Thymus	$289.00
Protein	OPSA11079	HUMAN EPHRIN B2 Recombinant Protein (25ug) Reacts with Application		$505.00
pAb	OASA08697	Pak3 Antibody (OASA08697) Reacts with Application WB		$715.00
pAb	OASA08545	PAK2 antibody - C-terminal region (OASA08545) Reacts with Application WB		$295.00
pAb	OASA07758	PTK2 Antibody (OASA07758) Reacts with Application IHC-FFPE		$715.00
pAb	OASA07724	EPHA4 Antibody (OASA07724) Reacts with Application IHC-FFPE		$715.00
pAb	OASA07320	Gsk3b Antibody (OASA07320) Reacts with Application WB		$715.00
pAb	OASA07240	Mapk3 Antibody (OASA07240) Reacts with Application WB		$715.00
pAb	OASA07137	CDK5 antibody - C-terminal region (OASA07137) Reacts with Application ELISA, IP, WB		$375.00
pAb	OASA07100	PPP3CA Antibody (OASA07100) Reacts with Application IHC-AFF, WB		$1,535.00
pAb	OASA06686	Cxcl12 Antibody (OASA06686) Reacts with Application ELISA, WB		$545.00
pAb	OASA06519	Cxcr4 antibody - N-terminal region (OASA06519) Reacts with Application ELISA, IHC-FFPE, WB		$435.00
pAb	OASA06415	RAC2 Antibody (OASA06415) Reacts with Application WB		$530.00
pAb	OASA06111	CFL2 antibody - C-terminal region (OASA06111) Reacts with Application ELISA, WB		$505.00
mAb	OASA02910	HRAS Antibody (OASA02910) Reacts with Application ELISA, WB		$265.00
mAb	OASA02621	MET Antibody (OASA02621) Reacts with Application ELISA, WB		$910.00
mAb	OASA02604	SEMA7A Antibody (OASA02604) Reacts with Application FC, IP, WB		$520.00
mAb	OASA01062	SEMA4D Antibody (OASA01062) Reacts with Application FC, IP, WB	human peripheral blood lymphocytes	$405.00
mAb	OASA00727	FYN Antibody (OASA00727) Reacts with Application IHC-AFF, IP, WB		$295.00
mAb	OASA00074	Itgb1 Antibody (OASA00074) Reacts with Application FC, IP	mouse peripheral blood lymphocytes mouse peripheral blood lymphocytes mouse peripheral blood lymphocytes	$335.00
pAb	AVARP09007_T100	RGS3 antibody - C-terminal region (AVARP09007_T100) Reacts with Bovine, Dog, Horse, Human, Mouse, Pig, Rat, Guinea pig, Rabbit, Chicken Application WB		$229.00
pAb	AVARP01017_P050	CDC42 antibody - N-terminal region (AVARP01017_P050) Reacts with Wuchereria bancrofti, Leucosolenia sp. AR-2003, cloud sponge, Choanoflagellate, Pea aphid, Yellowfever mosquito, Caenorhabditis elegans, Chicken, Pacific transparent sea squirt, Tunicate, Mosquito, Channel catfish, blue catfish, Caenorhabditis vulgaris, D Application WB	Human 721_B	$289.00
pAb	ARP65781_P050	LPHN1 Antibody - C-terminal region (ARP65781_P050) Reacts with Application WB	Human HeLa	$289.00
pAb	ARP64264_P050	SPAM1 Antibody - C-terminal region (ARP64264_P050) Reacts with Application WB	Human Jurkat	$289.00
pAb	ARP62762_P050	BRAT1 Antibody - C-terminal region (ARP62762_P050) Reacts with Application WB	Human HepG2	$289.00
pAb	ARP61345_P050	EFNA2 antibody - middle region (ARP61345_P050) Reacts with Bovine, Guinea pig, Human, Mouse, Pig, Rat, Chicken Application WB	Human Placenta	$289.00
pAb	ARP59101_P050	NRP1 antibody - N-terminal region (ARP59101_P050) Reacts with Bovine, Chicken, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat, African clawed frog, Zebrafish Application WB	Human HepG2	$289.00
pAb	ARP58905_P050	GNAI3 antibody - N-terminal region (ARP58905_P050) Reacts with Human, Mouse, Rat, Zebrafish, Bovine, Chicken, Dog, Guinea pig, Horse, Pig, Rabbit, African clawed frog Application WB	Human Brain	$289.00
pAb	ARP58766_P050	SLIT3 antibody - N-terminal region (ARP58766_P050) Reacts with Bovine, Horse, Human, Guinea pig, Mouse, Rabbit, Rat, Chicken Application WB	Human Muscle	$289.00

Aviva Systems Biology

Axon Guidance Pathway

Reacts with

Human, Dog, Mouse, Guinea pig

Application

WB

Reacts with

Bovine, Chicken, Dog, Horse, Human, Mouse, Rat, African clawed frog

Application

WB, IHC

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Application

Reacts with

Application

WB

Reacts with

Application

WB

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Application

IHC-FFPE

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IHC-FFPE

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Application

WB

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Application

WB

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ELISA, IP, WB

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IHC-AFF, WB

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Application

ELISA, WB

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Application

ELISA, IHC-FFPE, WB

Reacts with

Application

WB

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Application

ELISA, WB

Reacts with

Application

ELISA, WB

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Application

ELISA, WB

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Application

FC, IP, WB

Reacts with

Application

FC, IP, WB

Reacts with

Application

IHC-AFF, IP, WB

Reacts with

Application

FC, IP

Reacts with

Bovine, Dog, Horse, Human, Mouse, Pig, Rat, Guinea pig, Rabbit, Chicken

Application

WB

Reacts with

Wuchereria bancrofti, Leucosolenia sp. AR-2003, cloud sponge, Choanoflagellate, Pea aphid, Yellowfever mosquito, Caenorhabditis elegans, Chicken, Pacific transparent sea squirt, Tunicate, Mosquito, Channel catfish, blue catfish, Caenorhabditis vulgaris, D

Application

WB

Reacts with

Application

WB

Reacts with

Application

WB