Axon Guidance Pathway

Axon guidance refers to the process by which growing neural axons follow specific, predictable paths to reach their target locations. The tip of the growing axon is known as the growth cone and it is this part of the axon that senses guidance cues (also known as guidance factors) in the surrounding environment. The growth cone receptors respond to the various fixed and diffusible guidance cues and their gradients and respond accordingly. The response is in the form of directional changes in axon growth mediated by cytoskeletal changes. A broad array of signals can function as guidance cues, some of the most well-studied being Netrins, Ephrins and Semaphorins. Each guidance factor serves to attract or repel growth cones during neural development, although different cues can have diverse effects on distinct growth cones. It is the collective influence of the various cues that helps guide axons to their appropriate targets during development. The effects of guidance cues on axon growth can readily be studied in vitro with an array of commercially available factors. Elucidation of the processes that promote and inhibit axon growth during development may provide critical insights into neuroregenerative processes that could benefit patients with spinal cord injuries and other diseases of the nervous system^[1].

1. Harel NY and Strittmatter SM. 2006. Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury? Nat Rev Neurosci. Aug;7(8):603-16.

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Type	Catalog #	Product	Product Images	Price (USD)
Protein	OPSA11079	HUMAN EPHRIN B2 Recombinant Protein (25ug) Reacts with Human Application		$505.00
mAb	OASA00074	Itgb1 Antibody (OASA00074) Reacts with Mouse Application FC, IP	mouse peripheral blood lymphocytes mouse peripheral blood lymphocytes mouse peripheral blood lymphocytes	$335.00
mAb	OASA02910	HRAS Antibody (OASA02910) Reacts with Human Application ELISA, WB		$265.00
mAb	OASA02604	SEMA7A Antibody (OASA02604) Reacts with Human Application FC, IP, WB		$520.00
mAb	OASA00727	FYN Antibody (OASA00727) Reacts with Human Application IHC-AFF, IP, WB		$295.00
mAb	OASA02621	MET Antibody (OASA02621) Reacts with Human Application ELISA, WB		$910.00
mAb	OASA01062	SEMA4D Antibody (OASA01062) Reacts with Human Application FC, IP, WB	human peripheral blood lymphocytes	$405.00
pAb	AVARP01017_P050	CDC42 antibody - N-terminal region (AVARP01017_P050) Reacts with Wuchereria bancrofti, Leucosolenia sp. AR-2003, cloud sponge, Choanoflagellate, Pea aphid, Yellowfever mosquito, Caenorhabditis elegans, Chicken, Pacific transparent sea squirt, Tunicate, Mosquito, Channel catfish, blue catfish, Caenorhabditis vulgaris, D Application WB	Human 721_B	$289.00
pAb	ARP56124_P050	PPP3R1 antibody - N-terminal region (ARP56124_P050) Reacts with African clawed frog, Chicken, Human, Rabbit, Rat, Zebrafish Application WB	Human NCI-H226	$289.00
pAb	OASA07100	PPP3CA Antibody (OASA07100) Reacts with Application IHC-AFF, WB		$1,535.00
pAb	ARP50294_P050	UNC5A antibody - middle region (ARP50294_P050) Reacts with Bovine, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish, Chicken Application WB	Human HeLa	$289.00
pAb	OASA07758	PTK2 Antibody (OASA07758) Reacts with Human Application IHC-FFPE		$715.00
pAb	ARP49574_P050	SEMA6A antibody - middle region (ARP49574_P050) Reacts with Human, Horse, Mouse, Pig, Rat, Bovine, Chicken, Dog, Rabbit Application WB	Human OVCAR-3	$289.00
pAb	ARP38493_P050	NFATC4 antibody - N-terminal region (ARP38493_P050) Reacts with Bovine, Dog, Guinea pig, Horse, Human, Pig, Rabbit, Rat Application WB	Human 721_B	$289.00
pAb	ARP65781_P050	LPHN1 Antibody - C-terminal region (ARP65781_P050) Reacts with Application WB	Human HeLa	$289.00
pAb	ARP58905_P050	GNAI3 antibody - N-terminal region (ARP58905_P050) Reacts with Human, Mouse, Rat, Zebrafish, Bovine, Chicken, Dog, Guinea pig, Horse, Pig, Rabbit, African clawed frog Application WB	Human Brain	$289.00
pAb	P100975_P050	NFATC3 antibody - N-terminal region (P100975_P050) Reacts with Bovine, Chicken, Dog, Horse, Human, Mouse, Rat, African clawed frog Application WB, IHC	Human HeLa Human Thymus	$289.00
pAb	ARP58521_P050	RHOA antibody - middle region (ARP58521_P050) Reacts with African clawed frog, Bovine, Chicken, Dog, Human, Mouse, Rat, Sheep, Zebrafish Application WB	293T	$289.00
pAb	OASA06519	Cxcr4 antibody - N-terminal region (OASA06519) Reacts with Mouse Application ELISA, IHC-FFPE, WB		$435.00
pAb	ARP54630_P050	GNAI1 antibody - middle region (ARP54630_P050) Reacts with Bovine, Dog, Human, Mouse, Pig, Rat, Guinea pig, Horse, African clawed frog, Chicken, Zebrafish Application WB	Human brain human thryoid Hum. Fetal Brain	$289.00
pAb	OASA07320	Gsk3b Antibody (OASA07320) Reacts with Rat Application WB		$715.00
pAb	ARP49593_P050	LRRC4C antibody - N-terminal region (ARP49593_P050) Reacts with Dog, Horse, Human, Pig, Rat, Bovine, Chicken, Zebrafish Application WB	Human 293T	$289.00
pAb	ARP57446_P050	Srgap1 antibody - middle region (ARP57446_P050) Reacts with Bovine, Dog, Horse, Human, Mouse, Rabbit, Rat, Chicken, Guinea pig Application WB	Mouse Brain	$289.00
pAb	ARP45510_P050	UNC5C antibody - C-terminal region (ARP45510_P050) Reacts with Bovine, Dog, Guinea pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish, Chicken Application WB	Human Jurkat	$289.00
pAb	ARP30926_P050	JUN antibody - middle region (ARP30926_P050) Reacts with African clawed frog, Bovine, Chicken, Dog, Guinea pig, Human, Mouse, Pig, Rabbit, Rat, Zebrafish, Sheep Application WB	Human Fetal heart " href="http://m1.avivasysbio.com/catalog/product/cache/1/0/9df78eab33525d08d6e5fb8d27136e95/A/R/ARP30926-QC32444-WB-image-02.JPG"> sea urchin total embryonic	$289.00
pAb	ARP52307_P050	CHP antibody - N-terminal region (ARP52307_P050) Reacts with African clawed frog, Bovine, Chicken, Dog, Human, Mouse, Rat, Zebrafish Application WB	Human 721_B	$289.00
pAb	ARP58766_P050	SLIT3 antibody - N-terminal region (ARP58766_P050) Reacts with Bovine, Horse, Human, Guinea pig, Mouse, Rabbit, Rat, Chicken Application WB	Human Muscle	$289.00
pAb	OASA06111	CFL2 antibody - C-terminal region (OASA06111) Reacts with Human Application ELISA, WB		$505.00
pAb	ARP55526_P050	SEMA3D antibody - middle region (ARP55526_P050) Reacts with Dog, Horse, Mouse, Pig, Rabbit, Rat, Bovine Application WB	Human THP-1	$289.00
pAb	OASA07137	CDK5 antibody - C-terminal region (OASA07137) Reacts with Human Application ELISA, IP, WB		$375.00

Aviva Systems Biology

Axon Guidance Pathway

Reacts with

Human

Application

Reacts with

Mouse

Application

FC, IP

Reacts with

Human

Application

ELISA, WB

Reacts with

Human

Application

FC, IP, WB

Reacts with

Human

Application

IHC-AFF, IP, WB

Reacts with

Human

Application

ELISA, WB

Reacts with

Human

Application

FC, IP, WB

Reacts with

Wuchereria bancrofti, Leucosolenia sp. AR-2003, cloud sponge, Choanoflagellate, Pea aphid, Yellowfever mosquito, Caenorhabditis elegans, Chicken, Pacific transparent sea squirt, Tunicate, Mosquito, Channel catfish, blue catfish, Caenorhabditis vulgaris, D

Application

WB

Reacts with

African clawed frog, Chicken, Human, Rabbit, Rat, Zebrafish

Application

WB

Reacts with

Application

IHC-AFF, WB

Reacts with

Bovine, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish, Chicken

Application

WB

Reacts with

Human

Application

IHC-FFPE

Reacts with

Human, Horse, Mouse, Pig, Rat, Bovine, Chicken, Dog, Rabbit

Application

WB

Reacts with

Bovine, Dog, Guinea pig, Horse, Human, Pig, Rabbit, Rat

Application

WB

Reacts with

Application

WB

Reacts with

Human, Mouse, Rat, Zebrafish, Bovine, Chicken, Dog, Guinea pig, Horse, Pig, Rabbit, African clawed frog

Application

WB

Reacts with

Bovine, Chicken, Dog, Horse, Human, Mouse, Rat, African clawed frog

Application

WB, IHC

Reacts with

African clawed frog, Bovine, Chicken, Dog, Human, Mouse, Rat, Sheep, Zebrafish

Application

WB

Reacts with

Mouse

Application

ELISA, IHC-FFPE, WB

Reacts with

Bovine, Dog, Human, Mouse, Pig, Rat, Guinea pig, Horse, African clawed frog, Chicken, Zebrafish

Application

WB

Reacts with