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Axon Guidance Pathway

Axon guidance refers to the process by which growing neural axons follow specific, predictable paths to reach their target locations. The tip of the growing axon is known as the growth cone and it is this part of the axon that senses guidance cues (also known as guidance factors) in the surrounding environment. The growth cone receptors respond to the various fixed and diffusible guidance cues and their gradients and respond accordingly. The response is in the form of directional changes in axon growth mediated by cytoskeletal changes. A broad array of signals can function as guidance cues, some of the most well-studied being Netrins, Ephrins and Semaphorins. Each guidance factor serves to attract or repel growth cones during neural development, although different cues can have diverse effects on distinct growth cones. It is the collective influence of the various cues that helps guide axons to their appropriate targets during development. The effects of guidance cues on axon growth can readily be studied in vitro with an array of commercially available factors. Elucidation of the processes that promote and inhibit axon growth during development may provide critical insights into neuroregenerative processes that could benefit patients with spinal cord injuries and other diseases of the nervous system[1].

1. Harel NY and Strittmatter SM. 2006. Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury? Nat Rev Neurosci. Aug;7(8):603-16.

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    GNAI1 antibody - middle region (ARP54630_P050) in human thryoid using Western Blot
    GNAI1 antibody - middle region (ARP54630_P050) in Human Fetal Lung using Western Blot

    GNAI1 antibody - middle region (ARP54630_P050)

    Protein Name:Guanine nucleotide-binding protein G(i) subunit alpha-1
    Catalog #:ARP54630_P050
    Type: pAb
    Reacts with: Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Sheep, Yeast, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    CHP antibody - N-terminal region (ARP52307_P050) in Human 721_B using Western Blot
    CHP antibody - N-terminal region (ARP52307_P050) in Human Adult Liver using Immunohistochemistry

    CHP antibody - N-terminal region (ARP52307_P050)

    Protein Name:Calcineurin B homologous protein 1
    Catalog #:ARP52307_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: IHC, WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    SEMA4B antibody - N-terminal region (ARP49485_P050) in Human Brain using Western Blot

    SEMA4B antibody - N-terminal region (ARP49485_P050)

    Protein Name:Semaphorin-4B
    Catalog #:ARP49485_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    SPAM1 Antibody - C-terminal region (ARP64264_P050) in Human Jurkat using Western Blot
    SPAM1 Antibody - C-terminal region (ARP64264_P050) in Human 293T using Western Blot
    SPAM1 Antibody - C-terminal region (ARP64264_P050) in Hum. Adult Placenta using Western Blot

    SPAM1 Antibody - C-terminal region (ARP64264_P050)

    Protein Name:Hyaluronidase PH-20
    Catalog #:ARP64264_P050
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    RAC1 antibody - middle region (ARP57798_P050) in Human HepG2 using Western Blot
    RAC1 antibody - middle region (ARP57798_P050) in siRUVBL1 transfected human H1299 using Western Blot

    RAC1 antibody - middle region (ARP57798_P050)

    Protein Name:Ras-related C3 botulinum toxin substrate 3
    Catalog #:ARP57798_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    GNAI2 antibody - C-terminal region (ARP54632_P050) in Human Lung using Western Blot
    GNAI2 antibody - C-terminal region (ARP54632_P050) in human thryoid using Western Blot

    GNAI2 antibody - C-terminal region (ARP54632_P050)

    Protein Name:Guanine nucleotide-binding protein G(i) subunit alpha-2
    Catalog #:ARP54632_P050
    Type: pAb
    Reacts with: Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    NTN4 antibody - N-terminal region (ARP49645_P050) in Human MCF7 using Western Blot
    NTN4 antibody - N-terminal region (ARP49645_P050) in Mouse, Rat using Immunohistochemistry

    NTN4 antibody - N-terminal region (ARP49645_P050)

    Protein Name:Netrin-4
    Catalog #:ARP49645_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: IHC, WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    SEMA4F antibody - N-terminal region (ARP46421_P050) in Transfected 293T using Western Blot
    SEMA4F antibody - N-terminal region (ARP46421_P050) in human A431 using Western Blot
    SEMA4F antibody - N-terminal region (ARP46421_P050) in Human MIA-PACA2 using Western Blot
    SEMA4F antibody - N-terminal region (ARP46421_P050) in Human A431 using Western Blot

    SEMA4F antibody - N-terminal region (ARP46421_P050)

    Protein Name:Semaphorin-4F
    Catalog #:ARP46421_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    Itgb1 Antibody (OASA00074) in mouse peripheral blood lymphocytes using Flow Cytometry
    Itgb1 Antibody (OASA00074) in mouse peripheral blood lymphocytes using Flow Cytometry
    Itgb1 Antibody (OASA00074) in mouse peripheral blood lymphocytes using Flow Cytometry
    Itgb1 Antibody (OASA00074) in mouse peripheral blood lymphocytes using Flow Cytometry

    Itgb1 Antibody (OASA00074)

    Protein Name:Integrin beta-1
    Catalog #:OASA00074
    Type: mAb
    Reacts with: Mouse
    Application: FC, IP
    Product Size: 0.25mg
    Price (USD): $355.00
  • TRIAL 
    SEMA6A antibody - middle region (ARP49574_P050) in Human OVCAR-3 using Western Blot

    SEMA6A antibody - middle region (ARP49574_P050)

    Protein Name:Semaphorin-6A
    Catalog #:ARP49574_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    NFATC4 antibody - N-terminal region (ARP38493_P050) in Human 721_B using Western Blot
    NFATC4 antibody - N-terminal region (ARP38493_P050) in Hum. Fetal Brain using Western Blot
    NFATC4 antibody - N-terminal region (ARP38493_P050) in Human Lung Tissue using Immunohistochemistry

    NFATC4 antibody - N-terminal region (ARP38493_P050)

    Protein Name:Nuclear factor of activated T-cells, cytoplasmic 4
    Catalog #:ARP38493_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB, IHC
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    GNAI3 antibody - N-terminal region (ARP58905_P050) in Human Brain using Western Blot

    GNAI3 antibody - N-terminal region (ARP58905_P050)

    Protein Name:Guanine nucleotide-binding protein G(k) subunit alpha
    Catalog #:ARP58905_P050
    Type: pAb
    Reacts with: Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    NFATC3 antibody - N-terminal region (P100975_P050) in Human HeLa using Western Blot
    NFATC3 antibody - N-terminal region (P100975_P050) in Human Fetal Lung using Western Blot
    NFATC3 antibody - N-terminal region (P100975_P050) in Human Thymus using Immunohistochemistry
    Human Lung

    NFATC3 antibody - N-terminal region (P100975_P050)

    Protein Name:Nuclear factor of activated T-cells c3 isoform IB-Xa EMBL ACG55625.1
    Catalog #:P100975_P050
    Type: pAb
    Reacts with: Cow, Dog, Horse, Human, Mouse, Rat
    Application: IHC, WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    RHOA antibody - middle region (ARP58521_P050) in 293T using Western Blot

    RHOA antibody - middle region (ARP58521_P050)

    Protein Name:Transforming protein RhoA
    Catalog #:ARP58521_P050
    Type: pAb
    Reacts with: Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    LRRC4C antibody - N-terminal region (ARP49593_P050) in Human 293T using Western Blot

    LRRC4C antibody - N-terminal region (ARP49593_P050)

    Protein Name:Leucine-rich repeat-containing protein 4C
    Catalog #:ARP49593_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    UNC5C antibody - C-terminal region (ARP45510_P050) in Human Jurkat using Western Blot

    UNC5C antibody - C-terminal region (ARP45510_P050)

    Protein Name:Netrin receptor UNC5C
    Catalog #:ARP45510_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    JUN antibody - middle region (ARP30926_P050) in Human Fetal heart using Western Blot
    JUN antibody - middle region (ARP30926_P050) in sea urchin total embryonic using Western Blot

    JUN antibody - middle region (ARP30926_P050)

    Protein Name:Transcription factor AP-1
    Catalog #:ARP30926_P050
    Type: pAb
    Reacts with: Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    SLIT3 antibody - N-terminal region (ARP58766_P050) in Jurkat using Western Blot

    SLIT3 antibody - N-terminal region (ARP58766_P050)

    Protein Name:Slit homolog 3 protein
    Catalog #:ARP58766_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    NRP1 antibody - N-terminal region (ARP59101_P050) in Human HepG2 using Western Blot

    NRP1 antibody - N-terminal region (ARP59101_P050)

    Protein Name:Neuropilin-1
    Catalog #:ARP59101_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    EPHA5 antibody - middle region (ARP58460_P050) in Human Brain using Western Blot

    EPHA5 antibody - middle region (ARP58460_P050)

    Protein Name:Ephrin type-A receptor 5
    Catalog #:ARP58460_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    FES antibody - N-terminal region (ARP54608_P050) in Human Placenta using Western Blot

    FES antibody - N-terminal region (ARP54608_P050)

    Protein Name:Tyrosine-protein kinase Fes/Fps
    Catalog #:ARP54608_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    SEMA6D antibody - N-terminal region (ARP49584_P050) in Human 721_B using Western Blot

    SEMA6D antibody - N-terminal region (ARP49584_P050)

    Protein Name:Semaphorin-6D Ensembl ENSP00000453661 Ensembl ENSP00000348276
    Catalog #:ARP49584_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    RHOD antibody - C-terminal region (ARP42414_P050) in Transfected 293T using Western Blot
    RHOD antibody - C-terminal region (ARP42414_P050) in Human Liver Tissue using Immunohistochemistry
    RHOD antibody - C-terminal region (ARP42414_P050) in Human Bronchial Epithelial Tissue  using Immunohistochemistry

    RHOD antibody - C-terminal region (ARP42414_P050)

    Protein Name:Rho-related GTP-binding protein RhoD
    Catalog #:ARP42414_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat
    Application: WB, IHC
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    NFATC1 antibody - N-terminal region (P100981_P050) in Human Stomach using Western Blot
    NFATC1 antibody - N-terminal region (P100981_P050) in Human liver using Western Blot
    NFATC1 antibody - N-terminal region (P100981_P050) in liver using Immunohistochemistry.

    NFATC1 antibody - N-terminal region (P100981_P050)

    Protein Name:Nuclear factor of activated T-cells, cytoplasmic 1
    Catalog #:P100981_P050
    Type: pAb
    Reacts with: Dog, Guinea Pig, Human, Mouse
    Application: WB, IHC
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    SLIT1 antibody - middle region (ARP58765_P050) in Human Stomach using Western Blot
    SLIT1 antibody - middle region (ARP58765_P050) in Mouse gut tissue using Immunohistochemistry

    SLIT1 antibody - middle region (ARP58765_P050)

    Protein Name:Slit homolog 1 protein
    Catalog #:ARP58765_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
    Application: IHC, WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    DCC antibody - middle region (ARP46583_P050) in Human ACHN using Western Blot

    DCC antibody - middle region (ARP46583_P050)

    Protein Name:Netrin receptor DCC
    Catalog #:ARP46583_P050
    Type: pAb
    Reacts with: Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    CDC42 antibody - N-terminal region (AVARP01017_P050) in Human 721_B using Western Blot
    CDC42 antibody - N-terminal region (AVARP01017_P050) in human liver tissue using Immunohistochemistry

    CDC42 antibody - N-terminal region (AVARP01017_P050)

    Protein Name:Cell division control protein 42 homolog
    Catalog #:AVARP01017_P050
    Type: pAb
    Reacts with: Dog, Rabbit
    Application: WB, IHC
    Product Size: 100 ul
    Price (USD): $289.00

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