- Description of Target:
- The protein encoded by FADD is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade.
- Gene Symbol:
- FADD
- Official Gene Full Name:
- Fas (TNFRSF6)-associated via death domain
- Alias Symbols:
- GIG3; MORT1
- Tissue Tool:
- Find tissues and cell lines supported to express FADD.
- Protein Accession# :
- NP_003815
- Nucleotide Accession#:
- NM_003824
- Swissprot Id:
- Q13158
- Host:
- Rabbit
- Clonality:
- Polyclonal
- Protein Size (# AA):
- 208
- Molecular Weight:
- 23kDa
- Application:
- WB, IHC
- Partner Proteins:
- WAS, CDC42EP2, CDC42EP3, ITSN1, MCF2L, WAS, ACTR3, ANXA2, ARHGAP1, ARHGAP31, ARHGDIA, ARHGDIB, ARHGDIG, ARHGEF6, ARHGEF7, BAIAP2, BNIP2, C14orf1, C1orf103, CASP3, CASP7, CDC42BPG, CDC42EP1, CDC42EP2, CDC42EP3, CDC42EP5, CDC42SE1, CSPG4, DEF6, DOCK7, DOCK8, DOCK9, EEF1G, EIF2AK2, ERRFI1, FG
- Immunogen:
- The immunogen for anti-FADD antibody: synthetic peptide directed towards the C terminal of human FADD
- Product Format:
- Lyophilized powder
- Purification:
- Affinity Purified
- Complete computational species homology data:
- FADD antibody - C-terminal region (AVARP01012_P050)
- Predicted Homology Based on Immunogen Sequence:
- Human: 100%
- Datasheets / Downloads:
- Printable datasheet for
anti-FADD antibody
- AVARP01012_P050 - Peptide Sequence:
- Synthetic peptide located within the following region: AHLVGALRSCQMNLVADLVQEVQQARDLQNRSGAMSPMSWNSDASTSEAS
- Blocking Peptide:
- For anti-FADD antibody is Catalog # AAP30341 (Previous Catalog # AAPP00722)
- Key Reference:
- Thomas,L.R., et al., (2004) J. Biol. Chem. 279 (31), 32780-32785
- Reconstitution and Storage:
- Add 50 μl of distilled water. Final anti-FADD antibody concentration is 1 mg/ml in PBS buffer. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Product Protocols: FADD antibody tested with Human Fetal Thymus Tissue (AVARP01012_P050)
Aviva Systems Biology is the original manufacturer of this FADD antibody (AVARP01012_P050)
Click here to view the FADD antibody Western Blot Protocol
Product Datasheet Link: FADD antibody (AVARP01012_P050)
WB Suggested Anti-FADD Antibody Titration: 0.2-1 ug/ml
Positive Control: Fetal thymus
Western Blot image: 
Description of Target: The protein encoded by FADD is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade.
Questions pertaining to this data can be directed to techsupport@avivasysbio.com
Aviva Systems Biology’s FADD antibody (AVARP01012_P050) has been tested using other cell lysates and tissues. To obtain more data about this antibody please email us at info@avivasysbio.com.
To order by phone call us at (888) 880-0001, fax us at (858) 552-6975 or send an email to info@avivasysbio.com. Aviva manufactures this antibody so we can offer the best price. Please contact us to request pricing information.
All of Aviva’s products are guaranteed for the applications and experimental sample types mentioned in the datasheet below. Are you curious if this product will work for you? Please contact us at techsupport@avivasysbio.com
Product Protocols: FADD antibody tested by IHC with human kidney (AVARP01012)
Aviva Systems Biology is the original manufacturer of this FADD antibody.
Click here to view the FADD antibody Immunohistochemistry (IHC) protocol
Product Datasheet Link: FADD antibody (AVARP01012)
IHC Information:
Rabbit Anti-FADD Antibody
Catalog Number: AVARP01012
Paraffin Embedded Tissue: Human Kidney
Cellular Data: Epithelial cells of renal tubule
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X
IHC Image:
- Protocol:
- Tips Information:
See our General FAQ page.
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