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100 ul
$289.00
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MYC antibody - N-terminal region (ARP32708_P050)

Description of Target:
MYC is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this MYC gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma.The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
Gene Symbol:
MYC
Official Gene Full Name:
V-myc myelocytomatosis viral oncogene homolog (avian)
NCBI Gene Id:
4609
Alias Symbols:
c-Myc; MRTL; bHLHe39
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express MYC.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express MYC.
Swissprot Id:
P01106
Protein Accession #:
NP_002458
Nucleotide Accession #:
NM_002467
Host:
Rabbit
Clonality:
Polyclonal
Protein Name:
Myc proto-oncogene protein
Protein Size (# AA):
454
Molecular Weight:
50kDa
Application:
IHC, WB
Protein Interactions:
UBC; USP37; USP22; KDM1A; SKP2; SMAD7; SNRNP70; CEP57; LDOC1; BRD3; KIDINS220; MAX; CSNK2B; CSNK2A1; USP28; NMI; PFDN5; TP73; EP400; SP1; PIAS2; ZBTB17; IGF2BP3; PTRF; SDK1; MRPL53; PRKCDBP; PHLDB2; KNDC1; MZT2B; RIN3; NEK11; MICALL2; NLRX1; NABP2; MYC; M
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human MYC
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Purification:
Affinity Purified
Complete computational species homology data:
Anti-MYC (ARP32708_P050)
Predicted Homology Based on Immunogen Sequence:
Pig: 100%; Rat: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Guinea pig: 100%; Dog: 93%; Sheep: 93%; Horse: 86%; Bovine: 86%
Species Reactivity:
Human, Mouse, Pig, Guinea pig, Rat, Rabbit, Dog, Sheep, Horse, Bovine
Datasheets / Downloads:
Printable datasheet for anti-MYC (ARP32708_P050) antibody
Peptide Sequence:
Synthetic peptide located within the following region: MDFFRVVENQQPPATMPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQ
Blocking Peptide:
For anti-MYC (ARP32708_P050) antibody is Catalog # AAP32708 (Previous Catalog # AAPP03722)
Target Reference:
Frater,J.L., (2006) Cancer Genet. Cytogenet. 166 (2), 139-145
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Product Protocols: MYC antibody tested with Human Transfected 293T Cells (ARP32708_P050)

Aviva Systems Biology is the original manufacturer of this MYC antibody (ARP32708_P050)

Click here to view the MYC antibody Western Blot Protocol

Product Datasheet Link: MYC antibody (ARP32708_P050)

WB Suggested Anti-MYC Antibody Titration: 0.0625ug/ml
Positive Control: Transfected 293T

Western Blot image:


Description of Target: MYC is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this MYC gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma.The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.

Questions pertaining to this data can be directed to techsupport@avivasysbio.com

Aviva Systems Biology’s MYC antibody (ARP32708_P050) has been tested using other cell lysates and tissues. To obtain more data about this antibody please email us at info@avivasysbio.com.

To order by phone call us at (888) 880-0001, fax us at (858) 552-6975 or send an email to info@avivasysbio.com. Aviva manufactures this antibody so we can offer the best price. Please contact us to request pricing information.

All of Aviva’s products are guaranteed for the applications and experimental sample types mentioned in the datasheet below. Are you curious if this product will work for you? Please contact us at techsupport@avivasysbio.com

Product Protocols: MYC antibody tested by IHC with human muscle (ARP32708)

Aviva Systems Biology is the original manufacturer of this MYC antibody.

Click here to view the MYC antibody Immunohistochemistry (IHC) protocol

Product Datasheet Link: MYC antibody (ARP32708)

IHC Information:

Rabbit Anti-MYC Antibody
Catalog Number: ARP32708
Paraffin Embedded Tissue: Human Muscle
Cellular Data: Skeletal muscle cells
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X

IHC Image:

 
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