RBMXL2 Antibody - middle region (ARP40773_P050)

Catalog No: ARP40773_P050

WB Suggested Anti-RBMXL2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: 293T cell lysateRBMXL2 is supported by BioGPS gene expression data to be expressed in HEK293T

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human RBMXL2
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 85%; Dog: 77%; Guinea Pig: 77%; Horse: 77%; Human: 100%; Mouse: 77%; Rabbit: 85%; Rat: 85%
• Peptide Sequence: Synthetic peptide located within the following region: SSRDGYSSRDYREPRGFAPSPGEYTHRDYGHSSVRDDCPLRGYSDRDGYG
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-RBMXL2 (ARP40773_P050) antibody is Catalog # AAP40773 (Previous Catalog # AAPY01025)
• Sample Type Confirmation:

  RBMXL2 is supported by BioGPS gene expression data to be expressed in HEK293T

• Reference: Olsen,J.V., (2006) Cell 127 (3), 635-648

Target Info

• Gene Symbol: RBMXL2
• Gene Full Name: RNA binding motif protein, X-linked-like 2
• Alias Symbols: HNRPGT, HNRNPGT, HNRNPG-T
• NCBI Gene Id: 27288
• Protein Name: RNA-binding motif protein, X-linked-like-2
• Description of Target: The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. RBMXL2 has two RRM domains that bind RNAs. RBMXL2 has similarity to HNRPG and RBMY proteins and it is suggested to replace HNRPG protein function during meiotic prophase or act as a germ cell-specific splicing regulator. It primarily localizes to the nuclei of meiotic spermatocytes. This gene is a candidate for autosomal male infertility.This gene belongs to the HNRPG subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind RNAs. This gene is intronless and is thought to be derived from a processed retroposon. However, unlike many retroposon-derived genes, this gene is not a pseudogene. The encoded protein has similarity to HNRPG and RBMY proteins and it is suggested to replace HNRPG protein function during meiotic prophase or act as a germ cell-specific splicing regulator. It primarily localizes to the nuclei of meiotic spermatocytes. This gene is a candidate for autosomal male infertility. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-2215 AC100875.3 67063-69277 c
• Uniprot ID: O75526
• Protein Accession #: NP_055284
• Nucleotide Accession #: NM_014469
• Protein Size (# AA): 392
• Molecular Weight: 43kDa
• Protein Interactions: UBC; RABGGTA; FDXACB1; CAND1; COPS5; CUL1; CUL3; CUL4B; SUMO1; DYRK2; TRA2B;